Bianca Andreescu is the first Canadian to win a major in the professional era.
American lucky loser Reilly Opelka put up an intense battle to stun top seed Daniil Medvedev 7-6(5), 7-6(5) and reach the semi-finals in Den Bosch on Friday.
Belinda Bencic won two tiebreaks to beat teenage Russian seventh seed Mirra Andreeva
French Open champion Gauff is in line for a clash with fellow American Jessica Pegula.
The Polish eighth seed walloped Liudmila Samsonova 6-2, 7-5 to reach the Wimbledon semi-finals for the first time.
Sofia Kenin advanced to the Toray Pan Pacific Open semifinals with a 6-3, 6-4 upset of No. 3 seed Daria Kasatkina on Friday in Tokyo.
Sinner won in Cincinnati this week to claim his fifth title of a breakout season before the revelation that he avoided a ban over two positive tests
It was sweet victory for Japan's Miyu Kato as she bagged the mixed doubles crown with Tim Puetz after being disqualied from the women's doubles.
Carlos Alcaraz will be backed to extend his winning run at the Grand Slams to 16 matches following triumphant French Open and Wimbledon campaigns.
Andreescu back from the brink to down Muguruza
Images from Day 6 of the 2021 US Open in New York on Saturday.
Andreescu has rapidly become a home-country favourite
Canada's Bianca Andreescu has decided not to compete at the Tokyo Olympics due to the COVID-19 pandemic, the former US Open champion said.
Carlos Alcaraz swatted aside Serbian Dusan Lajovic as Canadian Bianca Andreescu cruised past American Sofia Kenin in straight sets at Miami Open.
Since claiming the title in her US Open main draw debut, Andreescu has had a trophy photoshoot atop Rockefeller Center and appeared on several US morning shows in New York to discuss her breakthrough win.
Third-seeded Jessica Pegula and fifth-seeded Coco Gauff each recorded straight-set wins to advance to the second round of the Rothesay International on Tuesday in Eastbourne, England.
The 20-year-old Canadian, who has not competed since she suffered a knee injury last October, said on Twitter she made the difficult decision because the COVID-19 outbreak has compromised her ability to reach her highest level of form.
Serbian Dusan Lajovic beat Andy Murray at the Miami Open on Wednesday, sending the Briton packing in the first round with his first hardcourt win of the season.
IMAGES from Day 5 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Friday.
Canada's Bianca Andreescu upset Greek seventh seed Maria Sakkari to reach the last 32, while Japan's Taro Daniel crushed world number 15 Alexander Zverev.
Bianca Andreescu rolls to first-round win at Strasbourg.
Serena Williams, Bianca Andreescu and Roger Federer have also pulled out of the Grand Slam.
Key facts and records of American Serena Williams and Canada's Bianca Andreescu
Bianca Andreescu, 19, the first Canadian to win a major in the professional era, prevented Serena Williams from equalling Margaret Court's record of 24 Grand Slam singles titles.
The 19-year-old's triumph, which came in her US Open main draw debut and against the undisputed queen of the sport, was the latest step in a meteoric rise for Andreescu and it dominated front pages across the country.
The 19-year-old Canadian, who a year ago had failed to qualify for the tournament but has gone on to become the sport's brightest young star.
The final will pit power against power when Andreescu takes on her childhood hero Williams, who claimed her first US Open title in 1999 before Andreescu was even born.
After a flawless first set from Mertens the tide turned in Andreescu's direction in the second when she fired a cross-court forehand winner to break the Belgian at love and take a 4-2 lead.
Canadians took to social media to hail their first tennis Grand Slam champion Bianca Andreescu after the 19-year-old's US Open win over Serena Williams.
Former French Open champion Jelena Ostapenko is the latest player to withdraw from the US Open, organisers of the tennis Grand Slam confirmed on Monday.
Canadian teenager Bianca Andreescu's Indian Wells triumph was not shown on television in her home country but that did not dampen the excitement across a nation where the future of women's tennis is suddenly looking as bright as ever.
'I have so much to look forward to in 2021, including the Olympics'
A clash of generations will decide the US Open on Saturday with Serena Williams taking a fourth crack at Grand Slam history against teenager Bianca Andreescu, who was not even born when the American lifted her first Flushing Meadows trophy.
Defending champion Iga Swiatek made it to her third final in four years at Roland Garros.
'I'm so humbled by the continuous support from my fans in Rome and I look forward to making my return soon.'
The 23-year-old Kazakh, whose previous best performance in a Grand Slam was reaching the quarter-final at the French Open last year, would like TO create history on the hallowed turf of the All England Lawn Tennis and Croquet Club.
Serena Williams, who had come into the first Grand Slam since in Auckland claiming her first title since becoming a mother, suffered an error-strewn 6-4, 6-7(2), 7-5 defeat by China's Wang Qiang in the third round at the Australian Open on Friday.
Kei Nishikori's hopes of playing at the US Open have faded further after the Japanese former world number four revealed he had tested positive for COVID-19 for a second time.
Andreescu suffered torn ankle ligaments at Miami Open