While all eyes will be on Nadal and Djokovic, US tennis legend John McEnroe said Andy Murray and Japan's Kei Nishikori are the two most likely players to spring a surprise.
Andy Murray will play in the singles at next week's Winston-Salem Open as he continues his comeback from hip surgery.
Maria Sharapova and Andy Murray have pledged to support relief funds for children affected by the invasion.
Andy Murray moved into the fourth round of the Australian Open in surreal circumstances on Saturday, completing a 6-2, 3-6, 6-2, 6-2 victory over Joao Sousa after his father-in-law had collapsed ill a few hundred metres away.
Former Britain No 1 Tim Henman has picked top-ranked Novak Djokovic as favourite for the Wimbledon, the third major of the season.
Andy Murray remains committed to playing a full part in Great Britain's Davis Cup defence despite the prospect of a packed schedule hampering the world number two's chances of leading the side to a repeat triumph.
The 32-year-old has not played singles since losing in the first round of the Australian Open in January to Spain's Roberto Bautista Agut, after which he underwent hip resurfacing surgery in a bid to salvage his career.
Novak Djokovic beat Daniil Medvedev in the US Open final to win a 24th Grand Slam singles title and equal Margaret Court's record haul.
Alcaraz outlasts Hurkacz, Ruud stunned at Canadian Open
24th seed American Sam Querrey caused the biggest upset at this year's Wimbledon as he stunned defending champion Andy Murray 3-6, 6-4, 6-7 (4), 6-1, 6-1, in the quarter-finals, on Wednesday.
Briton Andy Murray will take over from Novak Djokovic as World No 1 when the rankings are updated on Monday after his Paris Masters semi-final opponent Milos Raonic withdrew with a leg injury on Saturday.
Top seed Novak Djokovic made quick work of Tennys Sandgren at the Western and Southern Open on Tuesday, never dropping serve en route to a 6-2, 6-4 win over the American, while big-serving Milos Raonic enjoyed a straight sets win over Andy Murray.
Since 2003, one of Roger Federer, Novak Djokovic, Rafael Nadal or Andy Murray have won the title at Wimbledon, with the Swiss leading the way with eight titles.
Murray was coached by Lendl from 2011-14 before he rejoined his team in June last year, helping Murray capture his second Wimbledon title and his second Olympic gold in Rio.
Murray roared to a second-round win over little-known German qualifier Oscar Otte.
Novak Djokovic reasserted his rule over the hard-courts of Melbourne Park
With 'nothing to lose', Kuznetsov senses upset over vulnerable Murray
Emma Raducanu did not drop a set since arriving at Flushing Meadows and won over the rowdy crowds at the Billie Jean King National Tennis Center as she swatted aside more experienced opponents with the same ease as she hammered winners.
'I'd say there's very little chance I'd play singles during the grass (season). Potentially doubles, but I'm not trying to get ready for singles. I've only just started moving now'
Murray seeks assurance on quarantine issues before US Open.
World No 1 Andy Murray started his new season with a surprise 7-6(4), 6-4 loss to David Goffin in the semi-finals of the Mubadala World Tennis Championship in Abu Dhabi on Friday.
Naomi Osaka will defend her title at the US Open, organisers said on Wednesday, after she withdrew from this year's French Open and Wimbledon on mental health grounds.
Andy Murray became the first player to hold aloft the super-sized Queen's Club trophy for a fifth time after he beat Canadian big-server Milos Raonic 6-7(5) 6-4 6-3 in the final of the Aegon Championships on Sunday. The British top seed's title hopes appeared to be faltering when he trailed Raonic by a set and 3-0 down in the second set but the 2013 Wimbledon champion relied on his greater grasscourt pedigree to turn the match around.
World number one Andy Murray beat Romanian Marius Copil 6-4, 6-3 to reach the third round of the Madrid Open on Tuesday.
The rich and famous from around the world came to witness Roger Federer clash with local boy Andy Murray in the Wimbledon final on Sunday. Rediff.com gives you a glimpse of the famous faces that made it to the All England tennis lawns to witness history being made.
Andy Murray is undefeated since September, has won 24 matches in succession and his win-loss record since losing to Novak Djokovic in the French Open final is 53-3.
Second seed Daniil Medvedev will launch his bid to win his first major title against veteran Frenchman Richard Gasquet.
In the last eight months Ivan Lendl inculcated in Andy Murray the attributes he was known for. The Scot's back-to-back triumphs in the Olympics and US Open, says Bikash Mohapatra, is testimony to it.
Britain number one Andy Murray has admitted that he got distracted by Novak Djokovic's fitness issues during his Australian Open final defeat against the Serbian.
Britain number one Andy Murray has overtaken 14-time Grand Slam champion Rafael Nadal to claim the third spot in the ATP world rankings.
Wimbledon champion Andy Murray lost 3-6, 6-4, 6-2 to German Florian Mayer in the Qatar Open second round on Wednesday, his second competitive match since returning from a back injury.
"And going into the match having not lost on clay this year and having some big wins on the surface is important for me. I will just keep doing what I have been doing."
Federer, a 20-times Grand Slam champion and regarded as one of the greatest players of all time, announced last week that a persistent knee injury meant he was ending his 24-year career.
Japan's Kei Nishikori overcame second seed Andy Murray for a gruelling 1-6, 6-4, 4-6, 6-1, 7-5 see-saw victory on Wednesday to reach the US Open semi-finals.
Murray, who took a wildcard into the seaside event as a fitness test for next week's Wimbledon, looked sharp on a sun-baked centre court and tasted victory for the first time since beating Benoit Paire in the last 16 of Wimbledon 350 days ago.
The Swiss star underwent arthroscopic right knee surgeries in February 2020 and May 2020. Federer has played five tournaments since having those surgeries, all of which came this season.
Federer decided to end his Roland Garros campaign on Sunday, a day after winning a gruelling third-round match against Dominik Koepfer.
Johanna Konta hopes fellow Briton Andy Murray will be in action at this year's Wimbledon despite media reports claiming that the Scot has suffered a setback in his recovery from hip surgery.
Andy Murray crushed Stan Wawrinka 6-4, 6-2 to win his group at the ATP World Tour Finals on Friday and stay on course for a season-ending climax with Novak Djokovic.
Feliciano Lopez has denied any involvement in match-fixing after his name was mentioned in a media report concerning a doubles match with fellow Spaniard Marc Lopez.
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