Champions Leverkusen, who set a European record of 51 consecutive games without loss across all competitions last season, kept their unbeaten streak intact with a number of late equalisers.
Villa remain fourth on 56 points, three points above Spurs in fifth, having played a game more. West Ham are seventh on 44, three points behind sixth-placed Manchester United who have a game in hand.
Borussia Dortmund showed great composure to reach their third Champions League final after Mats Hummels' second-half goal earned the visitors a 1-0 victory against misfiring Paris St Germain for a deserved 2-0 aggregate win on Tuesday.
Mauricio Pochettino has left his job as Chelsea manager by mutual consent, the Premier League side announced on Tuesday.
The 2024 European Championship will be held in Germany from June 14-July 14. Following are the teams who have qualified for the tournament:
Liverpool climbed to the top of the Premier League table with a 2-1 victory over struggling Wolverhampton Wanderers on Saturday.
IMAGES from the Premier League matches played on Saturday.
A summary of Saturday's action in the English Premier League.
Summary of the Europa League semi-final matches played on Thursday.
Arsenal returned to the top of the Premier League with a comfortable 2-0 victory over relegation-threatened Luton Town
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
Third-placed Aston Villa are the surprise package of the season and Unai Emery's side face relegation-threatened Burnley while fifth-placed Spurs host a resurgent Bournemouth who have 19 points from their last seven games.
Arsenal are currently in fourth place and occupy the last Champions League spot with four games remaining.
Real Madrid midfielder Luka Modric came off the bench to net a stunning strike from the edge of the box late in the second half to secure a 1-0 home win over Sevilla on Sunday and stretch their lead at the top of La Liga to eight points.
Aston Villa claimed their first three points of the Premier League Season
Manchester United's Alejandro Garnacho scored with a magical overhead kick in the third minute to send the visitors on their way to a 3-0 victory over an Everton team already reeling in their first Premier League game after being docked 10 points.
Tottenham Hotspur hammered 10-man Aston Villa 4-0 in the Premier League on Sunday thanks to four second-half goals, allowing them to close the gap with their Birmingham rivals to two points in the chase for Champions League football next season.
English Premier League leaders Manchester City and Chelsea slugged out a magnificent 4-4 draw at Stamford Bridge.
Roundup of Champions League matches played on Wednesday night
"What's important for me is to give the best of myself for my club, and we're looking forward for Leo (Messi) to return to continue scoring and winning matches."
It was heartbreak for the Americans, who finished runners-up in 2008.
The duo, who escaped unhurt after an attempted carjacking last month, were not in the squad at Newcastle United last weekend due to "further security incidents" which the club did not elaborate on.
Emery's position is under the spotlight after two wins in Arsenal's last 10 league games with the latest setback coming in a 2-0 defeat at high-flying Leicester City on Saturday.
Leeds United's Premier League relegation fears heightened as they slipped to a 2-1 defeat at Aston Villa on Friday, leaving Jesse Marsch's side without a win in their last seven games in all competitions.
After a tense encounter finished 1-1 following extra time, Villareal's Rulli stepped up after every on-field player scored their spot kicks and he comfortably beat Spaniard De Gea
The 37-year-old Mikel Arteta played for Arsenal from 2011 to 2016 before moving to Manchester City as assistant manager, where he won the Premier League twice.
The defeat halted Brighton's impressive three-game winning streak which included a 4-1 win over Chelsea and a 3-1 victory at Arsenal in the League Cup on Wednesday.
Arsenal have appointed former Paris St Germain coach Unai Emery as their new manager, the Spaniard succeeding the long-serving Arsene Wenger, the Premier League club announced on Wednesday.
Diogo Jota and Mohamed Salah were on target as Liverpool edged Premier League strugglers Nottingham Forest 3-2.
Getting Arsenal back into the Champions League is manager Unai Emery's main goal, but the Spaniard said on Friday it won't be an easy job as the competition for a top-four finish in the Premier League is tough.
Images from Tuesday's action in the Premier League
A round-up of Wednesday's action in the UEFA Champions League
With no Champions League football for a third straight season, the financial realities are starting to bite and Arsenal will be desperate for some of their talented youngsters to come through.
'Every player needs that moment, that turning point ... to settle and hopefully now Arsenal can see what they paid for... 72 million pounds was seeming expensive until tonight'
Unai Emery was pleased that Arsenal kicked off their Europa League campaign with a 4-2 home win over Ukraine's Vorskla Poltava but could not hide his frustration at the concession of two late goals.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
The Gunners' only league defeat of the campaign was in September away to one of England's traditional top-six clubs, Manchester United, drawing criticism that their strong start to the season was based on wins against lesser opposition.
IMAGES from the English Premier League matches played on Wednesday
Granit Xhaka hammered two goals in what is expected to be his last game as Arsenal clinched a 5-o win over Wolves.
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