Liverpool's first loss of the season means they cannot finish the campaign unbeaten to match Arsenal's 'Invincibles' of 2003-04.
Manchester City moved 17 points clear of the pack with a 3-0 win at Fulham on Saturday
Chelsea remain in fourth place, and are two points off third-placed Leicester City who have a game in hand.
Manchester City showed that their weekend derby loss was a blip as Kevin de Bruyne and Riyad Mahrez both scored twice in a 5-2 win over Southampton
IMAGES from the English Premier League match played on Saturday
Chelsea is currently at the fourth place in the Premier League standings with 63 points from 37 matches.
Images from the English Premier League matches played on Sunday.
Liverpool manager Juergen Klopp took exception to Frank Lampard's comments after the Chelsea boss labelled the Premier League champions 'arrogant' following a touchline spat during Wednesday's 5-3 win at Anfield. At his news conference ahead of Sunday's trip to Newcastle United for their final game of the season, Klopp said Lampard had a lot to learn to keep his emotions in check after the fulltime whistle.
Chelsea moved into the Premier League's top four as Mason Mount's superb first-half goal earned them a 1-0 win at champions Liverpool who suffered a club-record fifth straight home league defeat on Thursday.
Images from the EPL matches played on Saturday
Chelsea's commanding start to the Premier League season continued with a 3-0 victory over Aston Villa on Saturday as their rivals for the title continued to look vulnerable.
Images from English Premier League matches played on Sunday.
He has been rumoured to join Barcelona in the summer transfer window.
A goal in added time by Diego Costa earned Chelsea a 1-1 draw against Manchester United on Sunday and preserved Guus Hiddink's unbeaten record while denying Dutch compatriot Louis van Gaal victory.
Liverpool moved into the Champions League qualifying spots after a 3-0 win at Burnley on Wednesday took them above Leicester City and into fourth place with one round of Premier League matches remaining.
Aston Villa returned to winning ways in stunning fashion as Ollie Watkins scored twice in a 3-0 away thumping of an abject Arsenal in drizzly north London on Sunday.
Manchester United's top-four aspirations suffered a setback as Louis van Gaal's side were blown away 3-0 by Everton.
Chelsea slipped up in their push for a Champions League spot when they lost 1-0 at home to Arsenal in the Premier League on Wednesday with Emile Smith Rowe's first-half goal settling the London derby after a defensive mix-up by the hosts.
A summary of Saturday's matches in the Premier League.
The Reds have won 28 of their 31 Premier League matches this season.
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Phil Foden and Riyad Mahrez scored two goals apiece as the hosts showed their impressive strength
Jose Mourinho's side had paid lavish sums to bolster key areas by this time last year but, having claimed the title at a canter, the motto of this transfer window seems to be: if it ain't broke, don't fix it.
Manchester City defender Eric Garcia has been released from hospital after he was injured in a collision with goalkeeper Ederson in their 3-0 win against Arsenal, the Premier League club said on Thursday. Garcia, 19, collided with the Brazilian goalkeeper late in Wednesday's game and received treatment for several minutes before being carried off on a stretcher and taken to the Manchester Royal Infirmary Hospital for further tests.
The government last month opened the door for elite sport to resume and the Premier League said it would restart its season on June 17.
A stoppage time goal by a heavily-bandaged Martin Skrtel spared Liverpool another deflating defeat as they drew 2-2 at home to Arsenal in the Premier League.
IMAGES from Premier League matches played on Sunday.
Champions Liverpool suffered a shock 1-0 defeat to lowly Burnley on Thursday, ending their 68 match unbeaten home record in the Premier League as their title defence continued to fade.
Four players tested positive for coronavirus in the latest batch of tests conducted by the English Premier League and announced on Wednesday. Russian Premier League club Lokomotiv Moscow said on Thursday that four of its players had tested positive for the novel coronavirus.
Solskjaer is also hoping to keep hold of striker Odion Ighalo until the end of the season.
Images from Sunday's action in the Premier League.
Manchester City shook off the impact of a COVID outbreak in their ranks to outclass Chelsea 3-1 at Stamford Bridge
The Premier League's 'Project Restart' envisages a return to play in June, once given the green light from government, with the remaining 92 matches held behind closed doors at neutral venues.
Chelsea are banking on a lavish shopping spree to give them more bite up front and much-needed solidity in defence after coach Frank Lampard spent last season relying heavily on a crop of inexperienced home-grown players.
Chelsea opened up a six-point lead at the top of the Premier League despite being held to a 1-1 draw against top-four hopefuls Southampton in an absorbing game at Stamford Bridge on Sunday.
Ben Johnson and Tomas Soucek scored second-half goals as West Ham United twice came back from a goal down to earn a 2-2 draw at home to Brighton and Hove Albion in the Premier League on Sunday.
West Brom's Dawson is villain and hero as Spurs' chances at League title fades; Leicester now need just one win from three games to claim EPL crown
Liverpool raised the bar so high and enjoyed such a huge winning margin in claiming the English Premier League title last season it would be churlish to doubt their credentials for a repeat showing.
The final match round of the campaign will take place on May 22, 2022 when all games will kick off simultaneously, it added.
Liverpool manager Juergen Klopp said the show of support for Ronaldo during their 4-0 win over Manchester United on Tuesday was the "moment of the game", as both sets of fans stood for a minute of applause following the death of his newborn son.
