Southgate said England had been forced to give players extra days' recovery and also tapered their training schedules as the country's hopes of qualifying for the Nations League finals were dashed after Sunday's 2-0 defeat by Belgium.
Arsenal turned around its recent poor form to beat Leicester 3-1 on Sunday
Frank Lampard, Chelsea's all-time leading scorer, netted against his old club when he came on as a late substitute for Manchester City to give the champions a 1-1 draw.
Wolves midfielder Leander Dendoncker then hit the post with a powerful shot before Portuguese winger Podence made it 2-0, meeting Pedro Neto's cross from the right with a superb cushioned volley in the 27th minute.
Goalkeeper Alisson Becker scored a stunning header in the fifth minute of stoppage-time as Liverpool snatched a 2-1 victory at the death against relegated West Bromwich Albion at The Hawthorns on Sunday.
Roberto Firmino scored twice as Liverpool boosted their hopes of Champions League football next season
Tottenham Hotspur lost their cool and their Premier League title hopes as they let slip a two-goal lead at Chelsea to draw a stormy London derby 2-2 on Monday.
Liverpool's Mohamed Salah ended his Premier League goal drought in style by scoring twice as the champions raided the capital again to crush West Ham United 3-1 on Sunday.
Images from the English Premier League matches played on Saturday.
Manchester United's winless run continued but they gave under-fire coach Louis van Gaal crumbs of cheer with a committed display in an entertaining 0-0 draw with Chelsea while Arsenal went top of the table on Monday.
The decision comes after the game's rule-making body IFAB last month gave the go-ahead for trials of additional 'concussion subs'.
Images from the EPL match played between Manchester United and Southampton on Monday.
De Bruyne out for up to six weeks due to injury, says Guardiola.
The former England international, who won the Premier League title in the 1994-95 season with Blackburn, is the only player to have scored 100 goals in the competition for two different clubs.
Liverpool forward Sadio Mane scored his 100th goal for the club to help secure a 3-0 victory over lively Crystal Palace in the Premier League at Anfield on Saturday.
Images from Saturday's action in the Premier League.
TThe switch to five subs - up from three - brings the Premier League in line with other major competitions in Europe.
Manchester United enjoyed perhaps their finest performance.
Chelsea got their Premier League campaign on track after 20-year-old right back Reece James helped them to a 3-1 win at Brighton & Hove Albion with a spectacular goal on Monday.
Antonio Conte spent the immediate aftermath of Chelsea's title-winning 1-0 victory at West Bromwich Albion on Friday being bounced skywards by his players but once back on terra firma his mind was already focusing on the next target -- the double.
Images from the EPL matches played on Sunday
Mason Greenwood's late winner earned Manchester United a 1-0 win at wasteful Wolverhampton Wanderers in the Premier League on Sunday, breaking the record for the longest unbeaten away run in English Football League history in the process.
Ole Gunnar Solskjaer's side, who had won their last ten away games in the Premier League, stay third on 27 points, a point behind second-placed Leicester.
Chelsea striker Tammy Abraham scored a late opportunist double to secure a 3-0 home win for Chelsea over West Ham United in the English Premier League on Monday.
IMAGES from the Premier League matches played on Sunday.
Arsenal snatched a dramatic 2-1 victory over Burnley to keep their title hopes on track after the referee Jon Moss awarded penalties to both sides and sent off home manager Arsene Wenger in injury time.
Roberto Firmino's 90th-minute header sent Liverpool back to the top of the Premier League with a 2-1 victory over Tottenham Hotspur, whose 11-match unbeaten run came to an end on Wednesday.
Manchester City's hopes of closing the gap on the Premier League pacesetters were frustrated as they were held to a 1-1 draw at home to lowly West Bromwich Albion on Tuesday.
Arsenal has scored 10 goals in 11 league games this season to find themselves 15th in the Premier League
Ten-man Arsenal suffered a 3-0 Premier League defeat at Leicester City on Sunday in another blow to their hopes of finishing in the top four and qualifying for the Champions League.
Manchester City moved 17 points clear of the pack with a 3-0 win at Fulham on Saturday
Chelsea remain in fourth place, and are two points off third-placed Leicester City who have a game in hand.
Manchester City showed that their weekend derby loss was a blip as Kevin de Bruyne and Riyad Mahrez both scored twice in a 5-2 win over Southampton
Images from the English Premier League matches played on Sunday.
Chelsea moved into the Premier League's top four as Mason Mount's superb first-half goal earned them a 1-0 win at champions Liverpool who suffered a club-record fifth straight home league defeat on Thursday.
Liverpool's first loss of the season means they cannot finish the campaign unbeaten to match Arsenal's 'Invincibles' of 2003-04.
Images from English Premier League matches played on Sunday.
He has been rumoured to join Barcelona in the summer transfer window.
Chelsea is currently at the fourth place in the Premier League standings with 63 points from 37 matches.
Liverpool manager Juergen Klopp took exception to Frank Lampard's comments after the Chelsea boss labelled the Premier League champions 'arrogant' following a touchline spat during Wednesday's 5-3 win at Anfield. At his news conference ahead of Sunday's trip to Newcastle United for their final game of the season, Klopp said Lampard had a lot to learn to keep his emotions in check after the fulltime whistle.
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