The Serbian top seed won a fourth successive title at the All England Club to take his overall Grand Slam tally to 21.
The Spaniard's withdrawal means Medvedev will be top seed at the March 1-7 event, which also features top-10 players Stefanos Tsitsipas and Alexander Zverev.
Federer, Nadal and Djokovic had made it near impossible for their peers to live, and thrive, amongst them. But the coming generation, which hasn't been as scarred by defeat at the hands of the Big 3, may make tennis unpredictable again.
Opelka edges Kyrgios to set up all-American final with John Isner in Houston
The grasscourt major will be held from June 27 to July 10.
Djokovic said the Spaniard remains his biggest rival.
Novak Djokovic cruised through his first singles match in Australia since being deported last year.
Walking out of the outside courts at the Balewadi stadium, his gait was assuring as he uttered, "no more singles for me".
Japan's Osaka suffered the injury in Madrid, forcing her to miss the WTA 1000 event in Rome in the leadup to the French Open.
Wimbledon will drop the titles "Miss" and "Mrs" before the names of female winners on its honour roll to match the men's boards in an attempt to modernise the tournament.
Surprise package Davidovich Fokina, who knocked out top-ranked Novak Djokovic and Indian Wells champion Taylor Fritz in the earlier rounds at Monaco, drew first blood by breaking Tsitsipas to take a 2-1 lead in the opening set.
Penpix of the top men's contenders at the 2021 Australian Open
Tennis Australia (TA) planned for players and their entourages to arrive in Victoria in mid-December to have time to undertake a mandatory two-week quarantine period before competing in January.
Stan Wawrinka let his tennis do the talking as he brushed off the after-effects of a cold to breeze into the fourth round of the Australian Open with a 6-2, 6-3, 7-6(3) victory over Lukas Rosol on Saturday.
World number one Novak Djokovic said on Wednesday he hopes rival Roger Federer will return to competitive action soon and be able to compete with the best again after the Swiss great said he would miss the Australian Open in January.
'The fact that I wasn't playing for several months beginning of last year allowed me to really get together with my team and work on my body, on my strokes, which has later helped me to achieve some great results.'
The Indian pair of Saketh Myneni and Ramkumar Ramanathan beat compatriots Yuki Bhambri and Divij Sharan in straight sets to advance to the quarter-finals of the Bengaluru Open 2 ATP Challenger, in Bengaluru, on Wednesday.
The Wimbledon champion began legal action against the ATP, challenging the fine imposed on him for failing to show for an interview.
Rafael Nadal will skip the Miami Open that begins later this month in a bid to recover from a back injury in time for the clay court swing
The 'Big Three' of men's tennis have found some "fresh energy" to thwart the charge of younger players on the tour, world number one Novak Djokovic said after setting up yet another title clash against his biggest rival against Rafael Nadal.
The fourth-seeded Indo-Canadian pair got the better of second seeds Jean-Julien Rojer of the Netherlands and Romania's Horea Tecau 4-6, 7-6(9), 11-9 in a close semi-final.
World No 1 Novak Djokovic has taken an unusual route to prepare for his title defence at Wimbledon by confirming his participation in doubles at next week's ATP grasscourt event in Mallorca, Spain.
In a statement, the tournament organisers said Querrey did not open the door for a doctor's visit on Monday and the family left the hotel next day without informing the reception.
ATP, WTA cancel China events, including Shenzen Finals
Nine-times champion Novak Djokovic says there are "positive signs" that his three-year ban on entering Australia will be waived so he can play at the next Australian Open in January.
Natela Dzalamidze will be able to compete at Wimbledon after she changed her nationality to represent Georgia
Djokovic's players body blindsided ATP player council, says Anderson.
IMAGES from Day 5 of the French Open at Roland Garros in Paris on Thursday.
Novak Djokovic has sealed the year-end men's world number one tennis ranking for the sixth time to go level with childhood hero Pete Sampras after closest rival Rafael Nadal opted against playing in the ATP Tour event in Sofia next week.
AELTC took the decision in the wake of Russia's invasion of Ukraine
Penpix of the top men's contenders at the 2021 French Open which begins on Sunday:
Danish teenager Holger Rune fought back from a set down to beat hot favourite Novak Djokovic 3-6, 6-3, 7-5 and win his first Masters title in Paris on Sunday.
Former world number one Andy Murray's quest for a first ATP title in over two years ended in defeat at the hands of top seed Aslan Karatsev at the Sydney Tennis Classic on Saturday, with the Russian easing his way to a 6-3, 6-3 win.
'My arm has been -- I have had an issue there for quite a while now. It has gotten bigger in the last couple of weeks, so I'm just trying to protect it.'
FFT President Gilles Moretton said that the one-week postponement will give the health situation more time to improve and optimise the chances of welcoming spectators at Roland-Garros.
WTA chief promises 'strong reactions' to ban on Russian, Belarusian players
Indian tennis player Prajnesh Gunneswaran finish runner-up at the Orlando Open, losing the summit clash of the ATP Challenger event to American Brandon Nakashima, in Orlando.
Friday's match was a straight shootout for a last-four place, with world number five Rublev the favourite having won his four previous matches against Ruud.
Top seed Carlos Alcaraz snapped Daniil Medvedev's 19-match win streak with a 6-3, 6-2 rout in the Indian Wells final on Sunday.
Rafael Nadal beat new world number one Daniil Medvedev 6-3, 6-3 in a rematch of their Australian Open clash to storm into the final of the ATP 500 event in Acapulco on Friday.
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