Lyon sealed top spot in the Europa League standings while Roma survived a red-card scare to reach the last 16 on a chaotic final league-phase night.
Aston Villa secured a 2-1 victory at Basel on Thursday, with goals from Evann Guessand and Youri Tielemans keeping their Europa League campaign on a strong footing.
IMAGES from the Europa League matches played on Thursday
AS Roma secured their place in the Europa League last 16 with a 3-2 home win over 10-man Porto on Thursday thanks to a Paulo Dybala double, advancing 4-3 on aggregate.
Francisco Moura's second-half strike earned hosts Porto a 1-1 draw against 10-man AS Roma in the first leg of their Europa League knockout round play-off on Thursday.
United climbed to fourth in the standings on 15 points going into the last round of matches, in a strong position to reach the knockout phase along with Spurs who are sixth with 14 points.
Forward Rasmus Hojlund scored twice to allow Manchester United to come back from a goal down and get a 2-1 win at six-times Czech champions Viktoria Plzen in the Europa League on Thursday.
Arsenal sailed through the Europa League group stages, winning five of their six group matches and take on Sporting next, who overcame Denmark's FC Midtjylland in their playoff.
Cristiano Ronaldo scored on his return to the starting line-up as Manchester United sealed a place in the Europa League knock-out rounds with a 3-0 victory over Sheriff Tiraspol at Old Trafford on Thursday.
With the away goals rule no longer in place this season, PSV missed a string of chances to force extra time with Eran Zahavi hitting the crossbar from three metres with the goal at his mercy in the 62nd minute.
Manchester United bounced back from their defeat with a 4-1 win over Real Betis in the first leg of their Europa League last-16 tie.
Defending champions Bayern Munich must face Diego Simeone's Atletico Madrid after they were drawn together in Champions League Group A alongside Salzburg and Lokomotiv Moscow.
IMAGES from the Europa League matches played on Thursday.
The teams finished level at 3-3 on aggregate in the tie but the Lisbon club advanced to the quarter-finals after Adan kept out Martinelli's weak effort.
Lionel Messi scored a penalty for the third Champions League game in a row with the Spaniards maintaining their winning start to the group stage.
She oversaw her first Europa League game in October when Leicester City hosted Zorya Luhansk.
Rashford scores a brace as Man United fight back to beat Omonia
Images from the UEFA Champions League matches played on Tuesday night.
Celtic, who won Europe's premier club competition in 1967, set up a clash with Romanians Cluj in the next stage after a 2-0 win at Nomme Kalju completed a 7-0 aggregate rout of the Estonian champions.
Images from Europa League matches played on Thursday.
Azeri champions Qarabag took a big step towards the playoff round with a 2-1 win at Cypriot side APOEL but Dinamo Zagreb left their progress hanging in the balance after the Croats played out a 1-1 home draw against Hungary's Ferencvaros.
Juventus progressed to the Champions League last 16 after a Cristiano Ronaldo goal and a late header from substitute Alvaro Morata gave them a comeback 2-1 home win over Hungarians Ferencvaros on Tuesday.
Images from action in the Europa League matches on Thursday.
A summary of Thursday's matches in the Europa League.
Red Star Belgrade, who won Europe's premier club competition in 1991, engineered a 2-0 home victory against HJK Helsinki thanks to a Richmond Boakye header and substitute Milan Pavkov's sweeping 90th-minute finish.
Cristiano Ronaldo scored the 750th goal of his remarkable career in a 3-0 win over Dynamo Kyiv on Wednesday
Having seen the domestic league and cup double go to Porto last term, Benfica missed a string of chances against PAOK in a one-sided first half as they enjoyed 72% of possession.
Ajax, semi-finalists last season, came from behind to beat PAOK 3-2 for a 5-4 aggregate win over the Greeks while Red Star knocked out FC Copenhagen on penalties after a bizarre shootout involving 22 spot-kicks.
Arsenal's young guns continued to shine as they dismantled Standard Liege 4-0 on a hectic night of Europa League action that produced a full house of Spanish victories on Thursday. A summary of the matches.
News of all that transpired on and off the football field
Barcelona's fourth defeat of the season left them seventh in the standings on 14 points after 10 games, 12 points behind leaders Atletico.
Kazakhstan's Astana fought back to beat a youthful Manchester United side 2-1 at home, Arsenal's woes continued as Frankfurt's Daichi Kamada scored twice to secure a 2-1 win.
Hungary's 30-year wait to play on the major championship stage will end in France next year after their 2-1 victory over Norway ensured that one of football's most storied nations qualified for the Euro 2016 finals.
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