The reigning champions have won 53 and drawn 11 of those 64 games, scoring 169 goals and conceding 42 for a total of 170 points.
A round-up of Wednesday's league stage matches in the UEFA Champions League.
Fiorentina, two goals down and reduced to 10 men, converted two quickfire penalties to draw 2-2 with AC Milan in Serie A on Sunday while a 12-minute hat-trick by German Denis gave Atalanta a 4-3 win at a stunned Inter Milan after they had trailed 3-1.
Photographic summary of the football matches played across Spain, Italy and France
News of all that's transpired on and off the football field
Images from football action around European leagues played on Sunday
A round-up of Tuesday night's matches in the UEFA Champions League.
Rediff.com looks at the five best goals from the concluding round in the league stage.
Photos from the football matches played on Sunday.
Images from Sunday's action in La Liga and Ligue 1.
A summary of Wednesday night's action in the UEFA Champions League.
A summary of football matches played across Europe over the weekend.
Alessandro Del Piero, almost certainly playing his last home game for Juventus at the age of 37, celebrated with a goal as the Serie A champions beat Atalanta 3-1 on Sunday to finish their campaign unbeaten.
Ronaldo's replacement Dybala scored in the 77th minute with a goal the Portuguese would have been proud of. After a quick exchange of passes, the Argentine twisted past Alessio Romagnoli and beat Gianluigi Donnarumma with a right foot shot.
Atletico Madrid took a giant step towards the La Liga title
Struggling Inter Milan are praying their penalty curse does not strike again when they face Serie A leaders Juventus on Saturday.
Second-half goals from Stephan Lichtsteiner and Emanuele Giaccherini sent Juventus four points clear in Serie A after they defeated Atalanta 2-0 in Bergamo on Saturday to finish the first half of the season unbeaten.
Roberto Firmino scored twice and Marquinhos and Philippe Coutinho also got goals as Brazil hammered Bolivia 5-0 in their opening World Cup qualifier in Sao Paulo on Friday.
Arsenal led a list of nine clubs who grabbed a second win in as many games in the Europa League group phase as France striker Olivier Giroud scored his 100th goal for the club in a 4-2 win at BATE Borisov on Thursday.
Former Real youth player Joselu pulled a goal back for Alaves in the 59th minute, powering in a header from a free kick, but Benzema rounded off the victory for second-placed Real with an exquisite solo run and goal in the 70th minute.
Napoli shot to the top of Serie A with a controversial 3-0 win at 10-man Inter Milan on Saturday as Claudio Ranieri suffered his first defeat in charge and was sent off at halftime.
A spectacular piledriver from Juan Cuadrado gave Serie A leaders Juventus a 1-0 win over Inter Milan, ending a run of seven successive Serie A wins for their opponents in a pulsating end-to-end match on Sunday.
Playmaker Kaka breathed new life into struggling AC Milan by scoring twice and 18-year-old Bryan Cristante claimed his first professional goal as they beat Atalanta 3-0 on Monday for only their fifth league win of the season.
Gonzalo Higuain pulled one back three minutes later with a typically opportunist goal, the Argentine's 13th in the league this season, to set up a tense final half hour.
Levante striker Roger Marti brushed off squandering a penalty to score the winning goal as his side pulled off a shock 2-1 La Liga victory at Real Madrid
Barcelona continued their rampant run of domestic form to beat Osasuna 2-0 away from home on Saturday and move to within two points of La Liga leaders Atletico Madrid, with Lionel Messi setting up goals scored by Jordi Alba and teenager Ilaix Moriba.
Aguero will not start against Man United: Guardiola.
Inter Milan's lead at the top of Serie A was cut when they lost 2-1 at home to Lazio on Sunday while AS Roma beat Genoa 2-0 to record their first win in eight games and ease the pressure on under-fire coach Rudi Garcia.
Juventus missed a chance to extend their advantage over second-placed AS Roma when they played out a dismal 0-0 draw away to Udinese on Sunday, while Napoli closed in on Serie A's top two with a 2-1 win at Chievo.
Manchester City's quadruple bid remained intact as Ilkay Gundogan and Kevin de Bruyne secured a 2-0 win at Everton in their FA Cup quarter-final clash
Inter Milan's influential playmaker Wesley Sneijder is a doubt for Wednesday's Champions League semi-final second leg in Barcelona due to a thigh problem.
Juventus forward Cristiano Ronaldo's knee problem is getting better but he still might have to sit out their Champions League match at home to Atletico Madrid, coach Maurizio Sarri said on Monday.
Inter Milan coach Jose Mourinho admitted he verbally abused a journalist after Sunday's 1-1 draw with Atalanta but denied that there was physical contact.
Juventus rehire Allegri.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
This time Liverpool are at home, and victory would put them nine points clear.
Francesco Totti scored a late penalty in AS Roma's 2-1 win over Cagliari to deny Inter Milan the chance to win the Serie A title with a game to spare on Sunday.
Inter Milan climbed back to the top of Serie A with a 3-1 home win over Atalanta on Saturday after Jose Mourinho's gamble with their title hopes paid off.
News of all that's transpired on and off the football field
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