With Serena bidding to become just the fourth woman to win all four grand slams in the same year, the US Open hype machine that already had been in top gear is now set to crank into overdrive.
Tennis ace Martina Navratilova has married her long-term partner Julia Lemigova in New York.
Fourth seed Kei Nishikori's hopes of making another magical U.S. Open run came to a quick end on Monday as last year's runner-up fell at the first hurdle, falling 6-4, 3-6, 4-6, 7-6 (6), 6-4 to Frenchman Benoit Paire.
World number one Novak Djokovic lost to rivals Roger Federer and Andy Murray in the finals of US Open warm-up events but the Serb insists those defeats have aided his preparations for the last grand slam of the season.
Karolina Pliskova suffered a narrow US Open defeat at the hands of Angelique Kerber on Saturday, but the Czech 10th seed also proved her mettle as one of the most dangerous attacking players in women's tennis.
Serena Williams will be wary of another semi-final slip-up when she takes to the Arthur Ashe Stadium court on Thursday to face 10th seed Karolina Pliskova for a spot in the US Open final.
Serena Williams stormed into the US Open quarter-finals in record-smashing style on Monday by easing past Kazakhstan's Yaroslava Shvedova 6-2, 6-3 to claim her record 308th Grand Slam match win.
Five-times champion Roger Federer reached his first US Open final in six years as he raced past fellow Swiss Stan Wawrinka 6-4, 6-3, 6-1 at Flushing Meadows in the semi-finals on Friday.
IMAGES from Day 8 of the matches played at the US Open at Flushing Meadows on Monday
A summary of Thursday's play at the US Open.
Former Olympic athlete and reality TV star Bruce Jenner, who is transitioning to life as a woman.
Second seed Roger Federer powered to a 6-4, 6-3, 6-2 win over Roberto Bautista on Tuesday, charging into the quarter-finals of the US Open for the 10th time in 11 years.
Despite boasting 34 Grand Slam singles titles between them, Serena Williams and Roger Federer were forced to share the spotlight with a 15-year-old at the US Open on Tuesday as all three advanced to the second round.
Marathon man Kei Nishikori secured a monumental upset by sweating out a 6-4, 1-6, 7-6(4), 6-3 win over world number one Novak Djokovic at the U.S. Open on Saturday to become the first Japanese man to reach a Grand Slam final.
Rafael Nadal, who said his injured wrist is improving daily, beat Denis Istomin of Uzbekistan 6-1, 6-4, 6-2 in his first-round match on Monday's opening day of the year's last Grand Slam.
Unseeded Sloane Stephens crushed fellow-American Madison Keys 6-3, 6-0 to win her maiden Grand Slam, in the US Open final, in New York on Friday.
Keys and Stephens to put friendship to grand slam test
Serena Williams, who held all four of tennis's grand slam titles for the second time in her career and won 53 of 56 matches in 2015, was named Sportsperson of the Year by Sports Illustrated magazine on Monday.
IMAGES from Day 3 of the US Open in New York on Wednesday.
A summary of the first day's play at the US Open.
I'd love to win Wimbledon and I think it's possible, says Roger Federer.
Germany's second seeded Angelique Kerber beat Czech Karolina Pliskova 6-3, 4-6, 6-4 to win the US Open final on Saturday, and collect her second Grand Slam title of the year.
While 40 have tried only nine times have both Williams sisters been beaten by the same player at the same tournament and that list reads like a Grand Slam Hall of Fame with names that include; Steffi Graf, Martina Hingis, Lindsay Davenport, Justine Henin and Kim Clijsters, who like Pliskova, pulled the double off at the US Open.
It was his first victory ever against a player ranked in the top two and it avenged the semi-final loss at the Rio Olympics where Murray went on to win gold and Nishikori settled for bronze.
Garbine Muguruza was once again left to sift through the remains of another failed US Open campaign after the third-seeded Spaniard suffered a shock 7-5 6-4 second round upset by unheralded Latvian Anastasija Sevastova on Wednesday.
Former world No.1 Ana Ivanovic suffered a shock 6-7(4), 1-6 loss against Denisa Allertova of Czech Republic in the women's singles first round at the 2016 US Open on Tuesday. Ivanovic, the 2008 French Open winner, started off well but failed to maintain her momentum. With the scored tied 6-6, the first set went into tie-break and the Serbian star failed to keep her nerves.
Rafael Nadal was exhausted yet exhilarated following his emotional return to action at this month's Rio Olympics after an injury-absence and is looking forward to gearing back up for the US Open starting on Monday.
Serena Williams overpowered German Carina Witthoeft 6-2, 6-2 to set up a third-round clash with big sister Venus at the US Open on Wednesday.
Andy Murray made another of his trademark stirring fightbacks as the third-seeded Scot powered past Frenchman Adrian Mannarino after dropping the first two sets of their second round encounter at a sweltering US Open in New York, on Thursday.
Fourth seed Angelique Kerber's bid for consecutive Grand Slam titles ended when 29th seed Dominika Cibulkova defeated the German 3-6, 6-3, 6-3 in the US Open third round on Saturday.
Images from Day 5 of the US Open in New York on Friday
World No 1 Novak Djokovic beat Roger Federer 6-4, 5-7, 6-4, 6-4 to win the US Open title at the Flushing Meadows in New York on Sunday.
Argentina's Juan Martin del Potro knocked out third seed Roger Federer to set up a semi-final against Rafael Nadal, in New York, on Wednesday.
Maria Sharapova will be back in the US Open spotlight on Wednesday hoping she can come up with a winning encore to her electrifying first round victory over second seed Simona Halep.
Flavia Pennetta crushed Romanian second seed Simona Halep 6-1, 6-3 to kick off a packed day of action at the U.S. Open on Friday with a stunning upset that put the Italian into her first Grand Slam final.
Lleyton Hewitt waved goodbye to the US Open on Thursday, the tenacious Australian dragged kicking and screaming to the Flushing Meadows exit by countryman Bernard Tomic.
World number one Novak Djokovic has enjoyed a whirlwind trip to Sunday's U.S. Open final, but the top-seeded Serb expects hard work ahead when he meets Stan Wawrinka at Arthur Ashe Stadium. Defending champion Djokovic, who became the third man to hold all four grand slam singles titles at once after his triumph at Roland Garros in June, owns a 19-4 career head-to-head advantage over the Swiss third seed.
Angelique Kerber has yet to lose a set in Flushing Meadows, but she has not faced the service firepower possessed by KarolinaPliskova, who has led the WTA Tour in aces in the last two seasons as well as at the US Open this year.
Stan Wawrinka outslugged Japanese sixth seed Kei Nishikori 4-6, 7-5, 6-4, 6-2 in energy-sapping humidity at Flushing Meadows on Friday to set up a US Open final against world number one Novak Djokovic.
Japan's Kei Nishikori overcame second seed Andy Murray for a gruelling 1-6, 6-4, 4-6, 6-1, 7-5 see-saw victory on Wednesday to reach the US Open semi-finals.
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