Barcelona and Sporting advanced to the Champions League knockout stage while Inter Milan and Chelsea missed the chance to guarantee their places on Tuesday.
With United unable to sign a replacement, the pressure will be on 21-year-old England forward Marcus Rashford to deliver the goals in a more central role than he has previously operated in.
Former Real youth player Joselu pulled a goal back for Alaves in the 59th minute, powering in a header from a free kick, but Benzema rounded off the victory for second-placed Real with an exquisite solo run and goal in the 70th minute.
A round-up of Wednesday's action in the UEFA Champions League.
Juventus suffered their first defeat of the season at Lazio but the champions put pressure back on Antonio Conte's side by moving one point clear at the top
'The only club where her husband replaced me was at Inter Milan where, in six months, he destroyed the best team in Europe at the time' 'And if she takes care of her husband's diet, she will have less time to speak about me'
Messi doesn't need to win a World Cup to prove his greatness, feels iconic former Argentine striker Hernan Crespo.
The 25-year-old Brazilian striker is to join Sao Paulo on a six-month loan, the Brazilian champions said on Wednesday.
Slovakia defender Milan Skriniar will be tasked with stopping Poland's Robert Lewandowski
Real Madrid defender Eder Militao has tested positive for COVID-19 ahead of their Champions League home game against Inter Milan.
Inter Milan got a crucial 1-0 win at Juventus on Sunday
Inter moved on to 68 points, ahead of Lazio on goal difference as the sides are level on their head-to-head records. They are eight points behind Juventus with six games to play.
Images from Sunday's action in La Liga, Serie A and Ligue 1.
News of all that's transpired on and off the football field
San Siro has become a hindrance rather than a help for Inter Milan, coach Roberto Mancini said following their 2-1 home defeat by champions Juventus.
IMAGES from soccer matches played across Europe on Sunday.
The Danish DBU football association tweeted that the Eriksen was 'awake and at Rigshospitalet for further examinations'
The AC Milan striker won the 2005 Golden Flop award.
AC Milan sneaked through to the semi-finals, beating Olympique Lyon 3-1 in the other second leg quarter-final with two late goals. Inter were eliminated on the 'away goals' rule.
Moroccan Yassine Bono denied Marcus Rashford, Bruno Fernandes, Mason Greenwood and Anthony Martial in either half of the match to keep the match alive
Inter Milan staged a fierce second-half fightback to draw 2-2 at Ajax Amsterdam.
Valencia midfielder Pablo Aimar was discharged from hospital on Sunday after spending the night under observation after a blow to the head.
'Racism is combatted with education, condemnation and discussion,' said the FIFA chief.
Rui Patricio saved three penalties as Wolverhampton Wanderers defeated English Premier League champions Manchester City to claim the Premier League Asia Trophy 3-2 in a penalty shootout.
Barcelona teenager Ansu Fati scored twice to lead his side to a 2-1 win at home to Levante on Sunday, finding the net in a league game for the first time in more than four months and becoming the youngest player to net a La Liga double. Romelu Lukaku scored a quickfire second-half double to give Inter Milan a 2-0 win at Udinese on Sunday, ending their run of three successive 1-1 league draws.
Ricardo Costa's goal gave Porto a 1-1 draw with Inter Milan in the Champions League first knockout round, first leg.
With sports events around the world suspended because of the coronavirus pandemic, football clubs and leagues have been discussing pay cuts with players to help them make it through the crisis.
Mourinho's side failed to turn their domination into more goals and things got edgy late on when Saville's shot evaded Gazzaniga who seemed slow to get down.
Barcelona wasted a golden opportunity to extend their lead at the top of LaLiga as they were shocked 1-0 at lowly Almeria on Sunday thanks to a first-half strike by El Bilal Toure.
News of all that transpired on and off the football field.
Images from football matches played in Europe on Sunday.
The much-travelled Ranieri won the Premier League title with unfancied Leicester City in 2016 and most recently coached French side Nantes.
Alessandria became the first third tier club to reach the Italian Cup quarter-finals in more than 30 years as their giant-killing run continued with a 2-1 extra-time victory at Serie A strugglers Genoa on Tuesday.
Aged 30, Pjanic's arrival has been criticised in some quarters as Barcelona's first-team is already viewed as ageing.
Images from the football matches played across Europe on Wednesday.
Tottenham Hotspur have called off talks with Antonio Conte to become their new manager to replace the sacked Jose Mourinho
The Frenchman said last month he could seek a new challenge elsewhere amid reports linking him to Juventus and Real Madrid.
Mario Balotelli lit up the Riviera derby with two goals on his Nice debut to hand them a 3-2 victory over Olympique Marseille on Sunday -- his first league goals for a year. The 26-year-old former Inter Milan and Manchester City striker opened the scoring from the penalty spot after seven minutes and struck again 12 minutes from full time when he headed home a Ricardo cross.
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