Fellow Serie A sides Atalanta and Lazio also won while Portugal's Vitoria Guimaraes began their match against Salzburg with not a single European player in the team.
Yet Milan's defensive frailty was punished when Konstantinos Fortounis scored from the penalty spot in the 81st minute to give his side the win that left them second in Group F on 10 points.
Javier Saviola and Oscar Cardozo scored two goals apiece and defender Luisao was also on target as Benfica thumped Everton 5-0 in the Europa League on Thursday.
A summary of Wednesday night's action in the UEFA Champions League.
Dries Mertens and Michy Batshuayi were also on target for Belgium while Eden Hazard impressed with creativity and speed for the hosts, who start their World Cup campaign on Monday against Panama in Sochi.
Goals from Jan Vertonghen and Jermain Defoe left Tottenham Hotspur on the cusp of the Europa League knockout stages as four other clubs maintained perfect starts on Thursday.
Arsenal and Galatasaray are facing disciplinary action after supporters of the Turkish club lit red flares and threw them onto the pitch, briefly holding up play, in their Champions League group match on Wednesday.
Defeats by Sweden and Russia have sealed the fate of the surprise Euro 2004 winners, who have yet to score a goal at the tournament and never looked like getting back into either game.
Sweden midfielder Christian Wilhelmsson is out of Euro 2008 because of a hamstring injury.
Red Star, who won the European Cup in 1991 and reached the latter stages the following season, finished second in Group H behind Arsenal who crushed BATE Borisov 6-0.
Images from the UEFA Champions League matches played on Wednesday.
Ajax were joined by Young Boys, who stunned Dinamo Zagreb 2-1 away for a 3-2 aggregate win over the Croatians, and AEK Athens who scraped a 1-1 home draw with FC Vidi after a 2-1 win in the first leg in Hungary.
Images from football matches played in Europe on Friday.
Pep Guardiola's ManchesterCity will play Romanian side Steaua Bucharest in the Champions League playoff round after the draw was made in Nyon on Friday.
On a good night for English clubs in the Europa League, Manchester United hammered AZ Alkmaar 4-0, while Wolverhampton Wanderers also thrashed Besiktas 4-0 in Group K, and Arsenal came from two goals down to draw 2-2 away to Standard Liege and finish first in their pool. The upset of the night came in Group J as Crivelli scored a 90th-minute winner against Borussia Moenchengladbach to send Basaksehir through and knock the Germans out, with AS Roma grabbing the runner-up spot thanks to a 2-2 home draw with Wolfsberger as the Europa League group stage concluded on Thursday.
Arsenal enjoyed a 3-0 win in Azerbaijan against Qarabag in the Europa League on Thursday and AC Milan beat Greece's Olympiakos Piraeus 3-1 but Sevilla suffered a shock defeat by Russians Krasnodar.
Olympique de Marseille were the fall guys on a hectic opening night of Europa League group stage action as German club Eintracht Frankfurt returned from the south of France with a surprise 2-1 victory on Thursday.
Germany's Ralf Schumacher will resume F1 testing with Williams next week despite being taken to hospital on Thursday suffering from a stomach problem.
Tottenham Hotspur exposed the weaknesses in Anzhi Makhachkala's star-shorn squad, winning 2-0 in Moscow to maintain their perfect start in the second round of Europa League group stage matches on Thursday.
Salah back in Liverpool squad but may not be risked at Genk, says Klopp
Paris St Germain will play Borussia Dortmund and Barcelona were pitted against an unpredictable Napoli, while Chelsea were drawn against Bayern Munich. City, who will be at home in the second leg, have yet to beat the Spanish side with two draws and two defeats in their previous four meetings.
A preview of the line-up action in the English Premier League
Napoli went down 3-1 at home to RB Leipzig, Arsenal and AC Milan enjoyed comfortable away wins, and Borussia Dortmund's Michy Batshuayi scored twice to secure a 3-2 victory in Europa League last 32, first leg action
Arsenal had scored 10 goals in two matches against BATE Borisov in the same competition in 2017 but never looked like being as prolific in the freezing temperatures of Belarus.
A Romelu Lukaku hat-trick in a 4-1 win for Everton at Young Boys and a thrilling 3-3 draw between Celtic and Inter Milan.
Inspired by 24-year-old playmaker Shoya Nakajima and forward Takumi Minamino, who finished the night with a brace, Japan stunned Oscar Tabarez's side, who are ranked fifth in the world.
Liverpool were beaten 1-0 away to Atletico Madrid in their last-16 first leg on Tuesday.
AC Milan, Villarreal and Nice reached the knockout stage of the Europa League after posting wins on Thursday in the penultimate round of the group stage.
Borussia Dortmund snatched a late goal at Atalanta to progress with a 1-1 draw, while AC Milan and Atletico Madrid, both with three-goal leads from the away legs, completed the formality of qualifying with 1-0 wins at home on Thursday.
Arsenal qualified for a 17th successive season with a nervy 1-0 win at home to Besiktas and Malmo made it for the first time with a 3-0 win over Salzburg, whose participation ended in the qualifiers for the ninth time in a row.
Luka Modric pulled one back for Zinedine Zidane's shellshocked side with a brilliant strike from distance early in the second half before substitute Vinicius Jr reduced the deficit to one goal.
At TCS, Chandrasekaran would be succeeded by Rajesh Gopinathan, currently the company's chief financial officer.
Ajax Amsterdam, returning to the stadium where they last won the Champions League 20 years ago, squandered a two-goal lead to draw 2-2 against 10-man Rapid Vienna on Wednesday.
All you must know about soccer's return to action after coronavirus
Tottenham Hotspur's Erik Lamela scored a stunning 'rabona' goal to light up Thursday's Europa League ties, wrapping his left boot round the back of his right leg 20 metres out and blasting the ball into the top corner.
Arsenal led a list of nine clubs who grabbed a second win in as many games in the Europa League group phase as France striker Olivier Giroud scored his 100th goal for the club in a 4-2 win at BATE Borisov on Thursday.
Ukraine's Metalist Kharkiv, due to play Schalke 04 in the Champions League playoff round later this month, have been kicked out of the competition, European soccer's governing body UEFA said on Wednesday.
Here's this week of photos that prove we live in a mad world.
A cold snap in Europe and parts of America has caused chaos and crippled the lives of thousands. There have been over 20 weather-related deaths across Europe -- with snow continuing to fall across the continent. In America, Washington was blanketed in white after the US capital was hit by its first snow of the year. Here are glimpses from the snow bomb.