Thomas Meunier volleyed a spectacular last-minute goal to give Paris St Germain a 2-1 win at FC Basel, which took them into the last 16 of the Champions League on Tuesday.
Chelsea returned to their early-season form to open up a five-point lead in the Premier League, Cristiano Ronaldo and Lionel Messi continued to make mincemeat of La Liga defences and Juventus extended their lead in Serie A. In France, Olympique Lyonnais retained top spot with a 2-0 win at RC Lens.
News of all that's transpired on and off the football field
Following this stunning turn-around of fortunes for Barcelona, here is a flashback of some of the best come-from-behind wins recorded in Europe's premier club competition.
News of all that's transpired on and off the football field
IMAGES from the Champions League matches played on Wednesday.
Images from the UEFA Champions League matches played on Wednesday
Juve forward Cristiano Ronaldo had an unusually quiet game after scoring a hat-trick against Atletico in last year's competition, although he came within inches of grabbing a last-gasp winner when he sent a shot just past the far post.
News of all that's transpired on and off the football field
Juventus striker Gonzalo Higuain again showed his killer instinct with two expertly-taken goals in a late 3-1 win at Torino after their less illustrious neighbours had scored first and dominated the Serie A game on Sunday.
Pep Guardiola says Manchester City are not yet ready to compete with Europe's elite but his side will be confident of opening their Champions League campaign with victory over Borussia Moenchengladbach on Tuesday.
Germany's defence will be put to the test in their opening Euro 2016 group match against Ukraine in Lille on Sunday with major questions still to be answered about the world champions' new-look rearguard.
Coritiba forward Joel Tagueu's goal celebration went spectacularly wrong when he jumped over an advertising hoarding and disappeared into a hole during a Brazilian championship match.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
A round-up of Wednesday's league stage matches in the UEFA Champions League.
Anthony Martial went from villain to hero as his second-half equaliser earned Manchester United a deserved point in a 1-1 draw against CSKA Moscow in Champions League Group B on Wednesday.
Photos from the Champions League matches played across Europe on Tuesday
Barcelona forward Lionel Messi equalled the Champions League scoring record of 71 goals when he struck for the second time in the 76th minute of Wednesday's Group F match at Ajax Amsterdam.
Photos from the Champions League matches played across Europe on Tuesday.