Manchester United manager Louis van Gaal will delve into the depths of his squad for the visit to Arsenal in the Premier League on Saturday, as an injury crisis engulfs Old Trafford.
Four months after quitting Liverpool for Manchester City, Raheem Sterling will have the first opportunity to justify the move by getting one over his former employers when the teams meet at the Etihad Stadium on Saturday.
Manchester City can pile the pressure on Premier League leaders Chelsea for the first time this season.
After Sunday's crushing 4-2 derby defeat at Manchester United, even a top four finish and a place in next season's Champions League is no longer a certainty.
Chelsea re-signed David Luiz and Premier League champions Leicester City broke their transfer record for striker Islam Slimani as English clubs exceeded the one billion pounds barrier when the curtain fell on transfer deadline day.
Bayern Munich defender Jerome Boateng returned to haunt his former club with a last-gasp goal that secured a 1-0 win over English title holders Manchester City in their opening Champions League Group E clash on Wednesday.
Images from the Champions League matches played across Europe on Wednesday.
David Silva came to the rescue of Manchester City with two goals in a 3-0 victory over Crystal Palace.
Chelsea and Manchester City tightened their stranglehold on the Premier League title race on Saturday, recording victories over struggling clubs to stretch further clear of their increasingly forlorn pursuers.
Manchester City manager Manuel Pellegrini will be back in the dugout after returning from suspension when City attempt to kick-start their Champions League campaign against a rampant, in-form AS Roma at the Etihad on Tuesday.
Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
Willian's late strike snatched a 1-0 home win for Chelsea over a stubborn Everton side to maintain lead.
A goal by Sergio Aguero gave Manchester City a 1-0 victory against neighbours Manchester United, who played with 10 men for more than 50 minutes on Sunday.
Liverpool target Chelsea after midweek tinkering, while third-placed Manchester City, whose hopes of qualifying for the Champions League knockout stage were dealt a severe blow in a humiliating 2-1 home defeat by CSKA Moscow on Wednesday, travel south to face struggling Queens Park Rangers.
Barcelona lost ground on La Liga leaders Real Madrid when their 11-match winning streak was snapped by Malaga, while Premier League pacesetters Chelsea dropped points at home to Burnley. Bayern Munich enjoyed a second-successive goalrush in the Bundesliga after routing Paderborn 6-0 while AS Roma lost ground to Serie A leaders Juventus after yet another draw. This and more from the happenings in the world of football over the weekend.
Photos from the Champions League matches played across Europe on Tuesday.