A goal from Brazilian Maicosuel gave Udinese a surprise 1-0 Italian Cup win over Inter Milan on Thursday while AS Roma also reached the quarter-finals with a 1-0 victory over Sampdoria.
A summary of Saturday's action in LaLiga, Ligue 1 and the Bundesliga.
Manchester United manager David Moyes would have been sacked already if he was in charge of a Serie A club, according to former Chelsea coach Gianluca Vialli.
Stefano Sturaro, who joined Genoa on loan from Juventus in January before the deal was made permanent, put the home side in front in the second half before fellow substitute Goran Pandev secured the shock result with 10 minutes remaining.
In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
Juventus moved to strengthen their midfield by signing Germany international and World Cup winner Sami Khedira from Real Madrid on a free transfer, the Italian champions said.
Dani Alves appeared to have won the game for Juventus when he headed them in front in the 83rd minute but Remo Freuler pounced to equalise six minutes later as he punished some sloppy defending.
On a seismic day in the history of Chelsea, Romelu Lukaku scored the winning goal in a 3-2 FA Cup fifth-round victory
Leonardo Bonucci and Alvaro Morata were on target as Juventus defeated Inter Milan 2-0 in the 'derby of Italy' to open a four-point lead at the top of Serie A on Sunday.
Atletico Madrid coach Diego Simeone is renowned for his wild touchline antics but a shrewd tactical move with a triple substitution swung Wednesday's Champions League game against Juventus firmly his side's way.
- 'We will have to play with a lot of intelligence' - 'We will be able to see a fantastic footballer on the pitch'
Pirlo started his first season in charge of a senior side looking to make it 10 successive Serie A titles for Juve, but the rookie coach struggled.
Inter Milan got a crucial 1-0 win at Juventus on Sunday
Juventus coach Massimiliano Allegri's decision to consign 40 million euro ($44.16 million) forward Paulo Dybala to the substitutes' bench appears to have backfired after his side's failure to score in their last two games.
Among other transfer news globally, defender Rahul Bheke joins Mumbai City FC while Locatelli completes Juventus move.
A round-up of Wednesday's action in the UEFA Champions League.
Domenico Berardi scored a hat-trick, including a so-called phantom goal, against AC Milan for the second season running to give Sassuolo a 3-2 win against opponents who finished the game with nine men on Sunday.
But if the five-times World Player of the Year is feeling frustrated by his mini-drought -- and his reactions on the pitch suggest he is -- his worries pale in comparison to Dybala's unhappy start to the season.
Juventus coach Massimiliano Allegri is expecting a "boring" match against AS Monaco in the Champions League on Tuesday, believing that both sides will adopt a cautious approach.
Images from the UEFA Champions League matches played on Wednesday.
A round-up of Saturday's action in Serie A, La Liga and Bundesliga.
A round-up of Tuesday's action in the UEFA Champions League.
Jose Mourinho was delighted that Manchester United were on the brink of signing France midfielder Paul Pogba from Serie A champions Juventus, the Portuguese coach said on Sunday.
The five-time world player of the year opened his account in the easiest possible fashion by tapping into an empty net from less than two metres in the 50th minute.
Alaba strike on Clasico debut gives Real Madrid 2-1 win at Barcelona.
Images from the matches played across football leagues in Europe on Sunday.
Bayern Munich thrashed Bayer Leverkusen 5-1, while Barcelona came from behind to beat Valencia 3-1 in LaLiga at Camp Nou on Sunday.
Borussia Dortmund beat Hertha Berlin 3-2 on penalties to reach the German Cup quarter-finals on Wednesday after the match finished 1-1 after extra time.
'There is a special bond in this team. There is something waiting to come out that is special. Hopefully that will come out next season'
Napoli suffered their first defeat of the season on Sunday when they lost 1-0 at lowly Atalanta while Serie A leaders Juventus surged on with a 3-0 win at Empoli, helped by a Gonzalo Higuain brace.
Serie A leaders Juventus scored twice in the last five minutes to win 3-2 at Inter Milan, who had earlier come from behind to lead despite playing with 10 men in an extraordinary match on Saturday.
Juventus coach Massimiliano Allegri criticised his players for letting their guard down and losing 2-1 at arch-rivals Inter Milan after taking the lead in the second half at the San Siro.
AS Monaco, beaten 2-0 at home in the first leg of their Champions League semi-final against Juventus, will have to make history in Tuesday's return if they are to end Ligue 1's long absence from the final.
Mbappe, 18, has scored 18 goals in his last 18 competitive games, including three in the 6-3 aggregate win over Borussia Dortmund in the last eight.
Real, Barca and Juve stand firm on Super League
Cristiano Ronaldo became the first player to score 400 goals in Europe's top five leagues as Juventus dropped points for the first time this season following a 1-1 Serie A draw with Genoa on Saturday. The Portuguese striker's fifth league goal for Juve carried him to the milestone, adding to his 84 strikes for Manchester United in the Premier League and 311 for Real Madrid in La Liga.
Napoli maintained their two-point advantage at the top of Series with a 2-0 victory at Lazio on Wednesday in a game suspended due to racist chanting as Juventus beat Genoa 1-0 to break a club record for consecutive league wins in a single season.
A summary of sports events and sports persons, who made news on Thursday.
Juventus defender Dani Alves produced an inspired display capped by a stunning volleyed goal in a 2-1 win over AS Monaco on Tuesday that took the Italians into their second Champions League final in three years.
Juventus continued their charge towards a fourth successive Serie A title as they predictably swept aside AC Milan 3-1 on Saturday to complete a league double over their old rivals.