It will be a poignant evening, with both games -- City vs Arsenal and Aston Villa vs Sheffield United -- played inside empty stadiums and marked before kickoff by a minute's silence for the more than 40,000 people to die of the virus in the UK.
City, storming towards their third league title in four years, scored three late goals to wrap up victory and move onto 65 points with 11 games left to play ahead of Manchester United on 50 points with a game in hand.
The winner will be named on August 26, along with UEFA's women's player of the year and Champions League positional award winners, at the Champions League group stage draw in Istanbul.
Images from the English Premier League matches played on Wednesday night.
Spanish media claims that the Barca talisman was in talks to move to City, a claim that City coach Guardiola denies.
Arsenal must trust in Arteta, says Guardiola.
Manchester City took a major step towards retaining their Premier League title with a 1-0 win over second-placed Chelsea on Saturday, opening up a 13-point lead at the top of the table for Pep Guardiola's side.
Manchester City must rebuild for title challenge: Guardiola
A round-up of Tuesday's action in the UEFA Champions League.
Aymeric Laporte's late header sealed a deserved 1-0 victory over Tottenham Hotspur
Trippier suspension temporarily halted by FIFA
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
A round-up of Tuesday's action in the UEFA Champions League.
A summary of Saturday's action in the Premier League.
City winger Riyad Mahrez and defender Aymeric Laporte previously tested positive for the novel coronavirus earlier this month.
Images from Saturday's action in the Premier League.
Liverpool moved to 76 points from 32 games with title rivals Manchester City on 74 points from one game fewer, with Pep Guardiola's side hosting Brighton and Hove Albion at the Etihad on Wednesday.
Chelsea beat Manchester City 1-0 on Saturday to book a place in next month's FA Cup final, thanks to a second-half goal by Hakim Ziyech which ended City manager Pep Guardiola's dream of steering his side to an unprecedented quadruple of titles.
'I always said I wanted to play abroad but the only thing that would stop me was if I was winning and successful on home shores. I was lucky I found a great club at Manchester United it would've been almost impossible for me to leave'
A round-up of Wednesday's action in the UEFA Champions League.
Manchester City's quadruple bid remained intact as Ilkay Gundogan and Kevin de Bruyne secured a 2-0 win at Everton in their FA Cup quarter-final clash
A round-up of Wednesday's action in the UEFA Champions League.
Manchester City reached their fourth straight League Cup final as second-half goals from John Stones and Fernandinho gave Pep Guardiola's side a 2-0 win over Manchester United in Wednesday's semi-final at Old Trafford.
A summary of Saturday's matches in the Premier League.
The perfectionist in Pep Guardiola forbids him to get remotely carried away by Manchester City's 100 per cent record this season even though they made it 10 wins out of 10 under their new Spanish manager on Saturday.
"Barcelona and Sergio Busquets signed this morning an agreement to renew the player's contract, which will end on June 30 2023," Barca said in a statement.
Manchester City crushed Leeds United 7-0 at the Etihad Stadium on Tuesday to make it seven Premier League wins a row and move four points clear at the top of the table.
German international Ilkay Gundogan scored twice and was at the heart of City's hugely impressive display as Pep Guardiola's side delivered the kind of football that took them to title wins in 2018 and 2019.
Although Spurs always looked more comfortable on the ball it was Sean Dyche's side, who have just a point from their opening five games, who had come the closest.
Barcelona hammered Real Valladolid 4-0 at home on Sunday to retain their La Liga crown and brushed aside any doubts that they were about to be usurped by Real Madrid as the top club in Spain.
Thousands of Manchester City fans lined the streets as the English Premier League champions celebrated with open-top bus parade.
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
IMAGES from the English Premier League matches played on Saturday
Guardiola gave a debut to close-season signing Nathan Ake, the Dutch defender signed from Bournemouth, lining up alongside John Stones in the centre of defence.
News of all that's transpired on and off the football field.
'By giving cameras unimpeded access to their world-class training facilities and coaches, and by showing off Guardiola's genius, All Or Nothing is a striking show of power, a declaration of their conviction of being the bigger club in Manchester,' says Dhruv Munjal.
City's Guardiola defends Mendy after COVID protocol breach.
Liam Delap, the son of former Stoke City defender Rory, scored the opener for Pep Guardiola's side in the 2-1 win at the Etihad Stadium
News of all that transpired on and off the football field