The six times world champion took the chequered flag at Imola 5.783 seconds ahead of team mate Valtteri Bottas, who started on pole position.
Lewis Hamilton did 94 laps of Barcelona's Circuit de Catalunya on the soft C2 compound in a sunny afternoon session
The front row lockout was a record-equalling 65th for champions Mercedes.
Hamilton's 98th career victory, from his 100th pole position, was his third win in four races
Sunday's Chinese Grand Prix will be the 1,000th race of the Formula One world championship since the first at Silverstone in 1950.
Seven-times world champion Lewis Hamilton became the first Formula One driver to take 100 pole positions after lapping fastest for Mercedes in Spanish Grand Prix qualifying on Saturday.
Formula One approved a plan to hold three sprint races instead of six in 2022 at an F1 Commission meeting on Monday, the FIA said in a statement.
Harry Kane scored twice as England stormed into the European Championship semi-finals for the first time in 25 years thrashing Ukraine 4-0 on Saturday to book a clash with Denmark.
Red Bull's Max Verstappen won Formula One's 70th Anniversary Grand Prix at Silverstone on Sunday to end Mercedes' run of domination and become champion Lewis Hamilton's closest challenger.
F1 winner from 1950s, Brooks dies aged 90
Valtteri Bottas roared to victory in the Japanese Grand Prix on Sunday as Mercedes clinched the Formula One constructors' championship for the sixth year in a row.
Michael Schumacher's wife, Corinna, said the Formula One great is "different, but he's here" as the 52-year-old continues his rehabilitation from a brain injury suffered in a skiing accident in December 2013.
The German, whose last victory was in Belgium in August 2018, took the chequered flag 2.641 seconds ahead of Monegasque team mate Charles Leclerc, who had started on pole position for the third race in a row.
Red Bull's Max Verstappen, last year's winner at his team's home circuit, qualified third.
Max Verstappen lapped with a best time of one minute 27.422 seconds.
World champion Lewis Hamilton, back in the car after his COVID-19-enforced absence at last week's Sakhir Grand Prix, was third but only 0.086 seconds off the pace.
Formula One leader Lewis Hamilton put Mercedes on pole position for their 200th race at the German Grand Prix on Saturday while engine problems dashed Ferrari's hopes.
Hamilton, who had also topped Saturday morning's final practice session, never look like being challenged throughout the qualifying hour.
Red Bull's Max Verstappen went fastest in Styrian Grand Prix practice, on Friday, while Australian Daniel Ricciardo crashed his Renault
The race has been won from pole eight times out of 11 editions.
'The phenomenal Max Verstappen was both sloppy and superb in Germany, getting caught out during the first two starts, and even spinning his car around to give the crowd something to gasp at with a Batmobile-esque 360 degree turn. 'After Hamilton crashed and Verstappen sniffed victory, though, he pounced hard, put his foot down, and took a deserved race win,' says Rediff's F1 columnist Raja Sen.
The crash at turn three of the Circuit de Catalunya on Wednesday morning was the first setback for the 2018 runners-up with a new SF90 car that has otherwise looked impressively quick and reliable.
Lewis Hamilton won a crazy, twice-halted Saudi Arabian Grand Prix for Mercedes on Sunday to go level on points with Red Bull rival Max Verstappen and set up a winner-takes-all title showdown.
Former Ferrari technical director Ross Brawn says 70th Anniversary race winner Max Verstappen reminds him of Formula One great Michael Schumacher. Brawn masterminded Schumacher's seven world championships with Benetton (1994 and 1995) and Ferrari (2000-04) and was team boss at Mercedes when the German made his comeback from 2010-2012.
Vettel, a four time world champion, is now 62 points adrift of the Briton.
Lewis Hamilton and the FIA were in a standoff at this month's Miami Grand Prix over piercings
'Cyrus was always very different. He would think before acting.'
Formula One championship leader Max Verstappen lifted himself into a league of his own as he beat title rival Lewis Hamilton to pole position with a blinding lap in qualifying for the French Grand Prix at Circuit Paul Ricard.
Hamilton said he had not been feeling well on Thursday and Friday, when he was also up until midnight working with his engineers.
IMAGES from the Hungarian Formula One Grand Prix on Sunday.
Sixty-five thousand fans were on their feet as they watched their home hero Max Verstappen fend off title rival Lewis Hamilton to snatch pole position for the returning Dutch Grand Prix on Saturday.
Lewis Hamilton led every lap from pole position to chequered flag, banging in a fastest lap for good measure to emphasise his supremacy
Buoyed by the success in a tiny but exclusive market, Lamborghini India, which operates dealerships in Mumbai, New Delhi and Bengaluru, is going to roll out another two, in Kolkata and Chennai, in the near future.
The Dutchman stopped Hamilton from winning an eighth title with a gutsy turn in the final lap.
The Saudi Arabian Grand Prix is the penultimate race on this year's Formula One calendar
Hamilton's team mate Valtteri Bottas finished third, ahead of Ferrari's Charles Leclerc, in a race aimed at providing more thrills for fans over the three days of track action and potentially shaking up the starting grid.
Formula One teams will operate in bubbles within bubbles when the season starts behind closed doors in Austria next week after being stalled since March due to the COVID-19 pandemic. There will be no spectators, no sponsors or VIP guests wandering the paddock and limited social interaction even between team mates.
The 21-year-old is the first Ferrari driver since seven times champion Michael Schumacher to take four consecutive poles in a single season.
Six-times world champion Lewis Hamilton and his team will take centre stage, hoping for another year of dominance after winning both titles for the past six years and ending up fastest in winter testing. Ferrari can be trusted to provide plenty of headlines with four-times champion Sebastian Vettel fighting to reassert himself at the team after being outshone by quick newcomer Leclerc, a double winner in 2019.
Ferrari's Sebastian Vettel, winner of 52 races, has gone more than a year since he tasted victory at last year's Belgian race.