The 22-year-old, who was looking to become the first Greek player to win a Grand Slam title, is, however, confident that he is on the right path to break the dominance of the two players who have won 11 of the last 12 majors.
Djokovic's challenger will be a 22-year-old who is bidding to become the first Greek to win a singles major.
Images from Day 9 of the 2020 French Open at Roland Garros, in Paris, on Monday.
She remained philosophical in defeat, however, saying that her expectations coming into the tournament had not been high.
Named after France's second-most decorated female player, the arena is nestled among the area's graceful 19-century greenhouses.
Serena Williams faces her first seeded opponent at the French Open on Thursday and will hope to use her booming serve to beat Australian Ashleigh Barty in the second round.
10 Interesting Glimpses from the French Open.
Former world number one Serena Williams returns to Grand Slam action for the first time in over 15 months, when she goes up against Czech Kristyna Pliskova in the French Open first round.
Nadal stretched his record of men's singles Grand Slam titles to 22
Rafael Nadal left German qualifier Yannick Maden no hope as he booked his ticket for the third round of the French Open in ruthless fashion with a 6-1, 6-2, 6-4 victory.
IMAGES from Day 11 of the French Open at Roland Garros in Paris on Wednesday.
French hope Kristina Mladenovic fought through the pain with a 3-6, 6-3, 8-6 win over American Jennifer Brady in the French Open first round on Monday.
Nadal, bidding for a record-extending 14th French Open title, won the first five games of the match as he looked on course to repeat his drubbing of the Serb in last year's final.
The Spaniard, who turns 36 next week, will next meet Dutch 26th seed Botic van de Zandschulp with a potential quarter-final looming against world number one Novak Djokovic who defeated him in last year's semi-finals.
Thiem knocked out by Andujar in French Open first round
Persistent rain showers accompanied by a flood warning washed out the entire day's play at the French Open on Monday for the first time since 2000.
Images from Day 10 of the 2020 French Open, at Roland Garros, in Paris.
Novak Djokovic survived a scare at the French Open to beat unseeded Argentine Diego Schwartzman in five sets.
Images from Day 7 of the 2019 French Open in Paris on Saturday.
Rafael Nadal gets the opportunity to avenge his only defeat in 10 meetings with Diego Schwartzman, which he suffered a little over two weeks ago, when Spain's 12-time French Open winner faces the Argentine in the semi-finals at Roland Garros on Friday.
Images from Day 6 at the French Open, at Roland Garros, in Paris, on Friday.
Nadal paid tribute to his uncle and coach Toni after winning a record-extending 10th French Open title on Sunday.
Images from Day 12 of the 2021 French Open at Roland Garros in Paris on Thursday.
Francesca Schiavone is considering giving her marriage -- with tennis, that is -- another chance.
The 20-times Grand Slam champion suggested after the third-round clash which ended past midnight that he could preserve himself for Wimbledon which begins on June 28.
Images from Day 6 of the 2021 French Open at Roland Garros in Paris on Friday.
IMAGES from Day 9 of the French Open at Roland Garros in Paris on Monday.
Sunday's final was an intense contest as nerves played their part, with 10 of the 22 games going against serve.
Images from Day 13 of the French Open, at Roland Garros, in Paris.
IMAGES from Day 8 of the French Open, at Roland Garros, on Sunday.
World number one Novak Djokovic said his win over Rafa Nadal in Friday's epic French Open semi-final was one of the top three matches he had played and he would remember it forever.
Russia's Anastasia Pavlyuchenkova stands on the threshold of finally delivering the title long predicted
Images from Day 5 of the French Open, at Roland Garros, in Paris.
The mother of one arrived at the 2019 French Open making another fashion statement
The twice Wimbledon champion, a semi-finalist at Roland Garros in 2012, looked poised and focused, treating the sparse Court Philippe Chatrier crowd to a few exquisite drop shots and lightning-quick forehands.
Order of play on the main show courts at the French Open.
Djokovic is the first man to reach 10 successive quarter-finals at the French Open
Barbora Krejcikova claimed her maiden Grand Slam title when she beat Russian Anastasia Pavlyuchenkova
The 34-year-old bellowed a series of frightening roars after completing a victory that at one stage looked like a formality but became increasingly fraught as Berrettini threw the kitchen sink at the Serb who becomes only the second man to reach 40 Grand Slam semi-finals after Roger Federer.
Defending French Open champion Maria Sharapova, on Wednesday, called for a change in schedule for the Fed Cup, saying playing ties after Grand Slam tournaments was "pointless".