Olympique Lyon coach Claude Puel is under no illusions that his side face a monumental task to reclaim a Ligue 1 title they owned for seven successive seasons without their two most influential players.
The spirit, which saw off Real Madrid earlier in the competition will be revived if Lyon are to fell Bayern Munich on Tuesday and book their place in a first Champions League final.
Under-fire Manchester United boss Jose Mourinho has been priced odds-on to be the first Premier League manager to leave his job this season.
Lille fought back from a goal down to win 3-1 at Nancy in Ligue 1 on Sunday but lost goalkeeper Tony Sylva.
'I can't comment on speculation. I don't bet and I don't do the lottery - it's not my way'
Manager Mauricio Pochettino bemoaned his side's first half display as Tottenham Hotspur's poor run of form continued with a disappointing 2-1 defeat at Leicester City in the Premier League on Tuesday.
A third successive league victory put Leicester City back above Chelsea into third place on goal difference with 23 points from 11 games.
Alexis Sanchez and Olivier Giroud were on target as Arsenal won 2-0 at Southampton on Wednesday to move up to fifth in the Premier League and fuel their hopes of a late push for the top four.
Brescia left Mario Balotelli on the bench after coach Fabio Grosso said the maverick striker had not put in enough effort in training during the week.
Arsenal substitute Pierre-Emerick Aubameyang scored twice in three minutes and captain Mesut Ozil played a starring role as they extended their winning run with a 3-1 victory over Leicester City in the Premier League on Monday.
World Cup winner Paul Pogba's third minute penalty and a late goal from Luke Shaw gave Manchester United a 2-1 win over Leicester City at Old Trafford in the opening game of the Premier League season on Friday.
News of all that's transpired on and off the football field
A summary of Thursday's matches in the English Premier League.
Manchester United's Romelu Lukaku should keep things simple as he tries to end his eight-game scoring drought, according to former United striker Dimitar Berbatov.
Buoyant Chelsea extended their Premier League lead and calmed nerves at Stamford Bridge with a 4-2 win over Southampton on Tuesday that moved them seven points clear of their nearest pursuers Tottenham Hotspur.
The Senegal international, 26, joined Liverpool from Southampton in 2016 for 34 million pounds ($43.8 million) and has scored 40 goals in 89 games for the Anfield club.
Manchester City stumbled to the most unexpected defeat of the Premier League season on Saturday before neighbours Manchester United began their brave new world under Ole Gunnar Solskjaer with a glorious reminder of long-forgotten attacking swagger.
The last three league meetings between the two sides, including October's game at Anfield, have ended in draws but Lovren said Liverpool were intent on coming away with all three points on Saturday.
Lionel Messi, Luis Suarez and Neymar were all on target as holders Barcelona beat Athletic Bilbao 3-1 on Wednesday to overturn a deficit from the first leg and advance to the quarter-finals of the King's Cup.
Tottenham Hotspur's Harry Kane pounced on a piece of comical defending to secure a 1-0 win over Sunderland in the Premier League on Sunday although he was later wheeled away on a stretcher after suffering an ankle injury.
News of all that's transpired on and off the football field
There may be little glamour in being a mid-table Premier League team but this season suggests that those clubs who become bored with such an existence can find the alternative is far worse.
Manchester City set a new top-flight record of 15 consecutive wins as their seemingly unstoppable march towards the English Premier League title continued with a 4-0 romp at bottom club Swansea City.
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
News of all that transpired on and off the football field.
Real Madrid goalkeeper Keylor Navas says the signing of Belgium keeper Thibaut Courtois has not affected his desire to remain at the triple European champions as he emphatically ruled out leaving the club in order to be assured of first team football.
Tottenham Hotspur's status as Premier League title chasers was seriously harmed on Saturday as they fell to a first defeat in seven league games, losing the lead to go down 3-1 at home to Wolverhampton Wanderers.
Manchester United's Zlatan Ibrahimovic proved his hunger for silverware has not diminished with age as the Swede's double earned a 3-2 win over Southampton in an absorbing League Cup final at Wembley.
Images from the English Premier League matches played on Tuesday
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Images from the English Premier League matches played on Saturday
Following is a match by match look at the English Premier League's weekend fixtures:
News of all that's transpired on and off the football field
Arsenal's Aubameyang compared to Henry after his derby double
Knee injuries have sidelined him for large parts of this season, however, and the Belgium international has started only four Premier League games.
News of all that's transpired on and off the football field
Manchester City made sure of third place in the Premier League when they romped to a 5-0 win at Watford on Sunday to ensure a Champions League berth for next season.
Images from the English Premier League matches played on Saturday
De Boer, who lasted only 77 days as Crystal Palace manager after losing his first four league games in charge with no goals scored, said in an interview on BT Sport that it was "a pity" Mourinho was Rashford's manager because he was not getting enough chances.