Leaders Bayern Munich eased past VfB Stuttgart 2-0 on Saturday to grab their first win of the year, as did Borussia Dortmund who beat Freiburg 3-0 to climb off the bottom of the Bundesliga table.
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Spanish playmaker Mata, 31, joined United in 2014 for a then club record transfer fee of 37.1 million pounds ($46.86 million) from league rivals Chelsea.
Belgium finished five points clear at the top of League A Group 2 and will meet world champions France and former World Cup winners Italy and Spain in the final four next October.
Departing Bayern Munich coach Pep Guardiola has been assured a bittersweet farewell at the German club with the pending celebration of a record fourth straight Bundesliga title soured by another failure to shine on the European stage.
Bayern Munich's party was wrecked by Borussia Moenchengladbach who hit back for a 1-1 draw at the Allianz Arena on Saturday, forcing the Bavarians to wait at least a week to clinch a fourth straight Bundesliga title.
Villarreal's Adrian Lopez produced a stinging sucker punch in stoppage time to leave Liverpool reeling and move the Spaniards closer to a maiden European final after their Europa League last four first leg clash finished 1-0 on Thursday.
Costa turned Juanfran's low cross into the net in the 69th minute for Atletico's third goal in the first leg of the last 16 tie against third division Lleida but immediately limped to the sidelines. He did return to the pitch, however, and completed the game despite bleeding from his knee.
Real Madrid are determined to create an intimidating atmosphere for visitors VfL Wolfsburg as they try to overturn a two-goal deficit in Tuesday's Champions League quarter-final second leg at the Santiago Bernabeu stadium.
Included in Barcelona squad to face Dortmund
Arsenal midfielder Aaron Ramsey says he has yet to reach an agreement with the Premier League club about his future. The Wales international, who joined the club in 2008, is in the final year of his contract.
Manchester United manager Louis van Gaal will delve into the depths of his squad for the visit to Arsenal in the Premier League on Saturday, as an injury crisis engulfs Old Trafford.
Harry Kane was hailed as 'unbelievable' after the England striker's 21st and 22nd goals of the season inspired Tottenham Hotspur to a routine win at hapless Aston Villa on Sunday that boosted their Premier League title ambitions.
An in-form Bayern Munich will be looking to notch up their fourth straight win in the Champions League group stage and seal a spot in the final 16 when the Bundesliga champions face Viktoria Plzen on Tuesday.
News of all that's transpired on and off the football field
Factbox on Jose Mourinho, who was named manager of Tottenham Hotspur on Wednesday
Barcelona's Lionel Messi and Luis Suarez secured victory over nine-man Atletico Madrid in La Liga's top of the table clash, while Juventus won a 12th straight Serie A game to stay hot on the heels of leaders Napoli.
Dele Alli condemned Champions League holders Real Madrid to a horrendous Wembley debut with two goals as Tottenham Hotspur reached the last 16 with a stunning 3-1 victory.
Liverpool's defence of a Premier League crown won at a canter last season has become a nightmare
Karim Benzema fired Real Madrid to a 1-0 win in the city derby against Atletico Madrid on Saturday which underlined Real's La Liga title credentials. Bayern Munich scored three goals in the opening 26 minutes to defeat Mainz 05 3-1 away on Saturday and go two points clear at the top of the Bundesliga with their sixth straight win.
Two late moments of Lionel Messi magic and a goal from Neymar helped Barcelona break the resistance of Bayern Munich in a pulsating 3-0 victory in their Champions League semi-final first leg at the Nou Camp on Wednesday.
The South American trio of Lionel Messi, Neymar and Luis Suarez reached a scorching 108 goals for the season following the La Liga leaders' 8-0 destruction of Cordoba on Saturday but the team's defence is yet to dispel doubts
Injury-ravaged Bayern Munich beat Hoffenheim 2-0 on Saturday, shrugging off a string of absences and their midweek Champions League defeat at Porto to close in on the Bundesliga title.
In-form Borussia Moenchengladbach struck three times in 14 minutes in the second half to floor champions Bayern Munich 3-1 on Saturday and inflict their first Bundesliga defeat of the season.
Cristiano Ronaldo renewed his personal battle with Lionel Messi by scoring his 71st Champions League goal, putting him three behind the Argentine's newly-set record, in Real Madrid's 1-0 win at FC Basel on Wednesday.
Bayern Munich moved closer to a record-extending 30th league title after their Polish striker Robert Lewandowski ended a personal jinx in a 5-0 drubbing of struggling Fortuna Duesseldorf in the Bundesliga on Saturday. The result left leaders Bayern, who are chasing an eighth successive league title, top of the standings on 67 points from 29 games, 10 ahead of closest rivals Borussia Dortmund who visit bottom team Paderborn on Sunday.
Napoli rediscovered their scoring touch as they brushed aside Inter Milan 3-0 on Friday, sending their opponents' new coach Stefano Pioli back to the drawing-board.
London clubs' erratic start to the Premier League season improved with victories for Chelsea, Tottenham Hotspur and Arsenal on Saturday but Manchester sides continued to make the running, with City and United the top two.
Despite their first-leg advantage, Pochettino warned against complacency and said he wanted his team to play for another win, although they have had one day less to prepare than the Germans.
IMAGES from the English Premier League matches played on Sunday
AS Roma's Daniele De Rossi celebrated his 500th appearance for the club with a goal in their 3-1 win over Empoli at the Olympic Stadium as they moved up to second place in Serie A on Saturday.
Bundesliga champions Bayern Munich suffered their first league defeat in 18 months when they slumped to a 1-0 loss at Augsburg on Saturday as Sascha Moelder's first-half strike ended their record 53-game unbeaten league run.
Barcelona have been haunted by their recent failures in the Champions League and there are concerning signs for the Catalans as they prepare for Tuesday's last-16 first leg away to Olympique Lyonnais.
A round-up of Saturday's football action in La Liga, Bundesliga and Ligue 1.
Hoffenheim ended champions Bayern Munich's 19-game winning streak in the Bundesliga on Saturday with a 3-3 draw after first taking the lead and then fighting back from two goals down.
All the latest football news from around Europe.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field