City are looking to retain the title they won in record-breaking fashion last year and secure their fourth Premier League crown in eight years.
Defeat left United in sixth spot, three points behind fourth-placed Chelsea, who they face this weekend.
The best way for City to defend in the past has been to attack. They have no reason to change that, says Vincent Kompany
Liverpool laboured to a 2-0 win over Denmark's Midtjylland on Tuesday as a goal from Diogo Jota and a Mohamed Salah penalty secured a hard-fought Champions League Group D victory at Anfield.
Injured Bayern Munich winger Arjen Robben is unlikely to recover in time for the side's Champions League quarter-final return leg in Benfica next week, coach Pep Guardiola said on Friday.
Manchester City struck an early blow for the forthcoming Premier League campaign as they beat Liverpool on penalties to win the Community Shield at Wembley on Sunday after an absorbing contest had finished 1-1.
Images from the English Premier League matches played on Sunday.
Chelsea ticked off three more points in their Premier League title quest with a 2-1 victory over Manchester City on Wednesday but Tottenham Hotspur's Houdini-like 3-1 win at Swansea means the race is far from over.
Phil Foden and Riyad Mahrez scored two goals apiece as the hosts showed their impressive strength
Manchester City manager Pep Guardiola will not allow his players time off for Christmas as he wants to ensure they are fully prepared for Monday's English Premier League trip to basement team Hull City.
City, who have dished out a string of maulings in a stellar league campaign, found the Championship side a tough nut to crack and had to wait until the 92nd minute to grab the winner when Argentine substitute Aguero darted in to head home.
Monaco swept into the Champions League quarter-finals and left Manchester City to pick up the pieces of another failed European campaign after a 3-1 victory on Wednesday sent them through on away goals.
Bayern Munich midfielder Bastian Schweinsteiger will be given the choice of whether to stay or leave the Bundesliga champions, manager Pep Guardiola said on Thursday.
Manuel Pellegrini's record against Pep Guardiola is a sorry one but he gets another chance to finally put one over his tormentor when Manchester City host holders Bayern Munich in the Champions League on Wednesday.
Barcelona coach Luis Enrique is leaving the Spanish La Liga champions at the end of the season when his contract expires after three trophy-laden seasons at the club.
Liverpool face Spurs in the game of the weekend, a day after title rivals Manchester City travel to struggling Fulham.
Pep Guardiola will return to the Nou Camp in the Champions League group stage after his new club Manchester City were drawn against his former Barcelona team on Thursday. The two sides were drawn in Group C alongside Borussia Moenchengladbach and former European champions Celtic in one of the toughest of the eight sections. Spanish coach Guardiola, who won the Champions League twice with Barca, faced the Catalans when he was in charge of Bayern Munich two seasons ago and suffered a 5-3 defeat in the semi-finals.
Successive home defeats by leaders Leicester City and second placed Tottenham Hotspur have left City six points off the pace with serious doubts about whether their expensively-assembled squad is still playing for the manager.
Diaz double puts City in quarters, De Bruyne injured
Manchester City chalked up yet another victory to maintain their stranglehold of the Premier League title race but pursuers Manchester United and Leicester City both secured important wins to enhance their top-four bids on Sunday.
City's Aguero doubtful starter for Watford trip
Liverpool's Champions League winning trio of Mohamed Salah, Virgil van Dijk and Sadio Mane joined regulars Cristiano Ronaldo and Lionel Messi on the shortlist for The Best FIFA Men's player award
Bayern, who won the Champions League in 2013, have yet to hit top form this season, with many players tired after the World Cup and others, including Thiago Alcantara, Bastian Schweinsteiger and Rafinha, out injured.
Liverpool may have to wait a little longer for their Premier League title celebrations after they were held to a 0-0 draw at Everton in the behind closed-doors Merseyside derby on Sunday.
Manchester City have dominated English football in recent years under Pep Guardiola, although they finished second to Liverpool in the Premier League this season, but have yet to add Europe's most coveted prize to their trophy cabinet.
Images from Saturday's action in the English Premier League.
Juergen Klopp has said his Liverpool team must be prepared to play ugly football to secure Champions League qualification following the injury to productive forward Sadio Mane ahead of Wednesday's Premier League clash against Bournemouth.
Eight wins and a draw in their last nine games had seen Leicester emerge as the closest pursuers of runaway leaders Liverpool but they went down 3-1 at the Etihad despite taking an early lead through Jamie Vardy. Images from the English Premier League matches played on Saturday.
Tottenham Hotspur and Liverpool raised the spirits with a rip-roaring 2-2 draw in a pre-Christmas Premier League classic on Sunday after a weekend marred by COVID-19 related postponements.
Several Manchester United players are in the 'red zone' according to manager Louis van Gaal as he weighs up his options for Saturday's FA Cup third round tie at home to Sheffield United. A hectic holiday programme, including four games in 15 days, has taken its toll on United's squad and Van Gaal fears that many of his over-stretched players risk injury or burnout. Defender Phil Jones is ruled out through injury while winger Ashley Young might not be risked with United set to face a Premier League clash at Newcastle United three days after playing third tier Sheffield United.
Manchester City will attempt to overturn their two-year UEFA ban from European football when a three-day hearing at the Court of Arbitration for Sport in Switzerland begins on Monday. European soccer's governing body UEFA ruled in February that City had committed serious breaches of Financial Fair Play (FFP) regulations and failed to cooperate with its investigation, handing them a ban and a 30 million euro (24.9 million pounds) fine.
Chelsea's third successive league win lifted them level on 18 points with Leicester City but are top thanks to a better goal difference. Leicester face Liverpool on Sunday.
Images from Wednesday's action in the UEFA Champions League.
Seconds after Bournemouth had a chance to snatch victory the ball went back down the other end and Sterling's deflected shot looped past helpless Bournemouth keeper Asmir Begovic.
Their work in the transfer market has also added to the positivity around the club after German manager Juergen Klopp made some major moves that have clearly strengthened his squad.
"First we have to play football and see what happens. Maybe we can then score a goal and create an atmosphere in the stadium."
UEFA had banned City from European competition for two years after ruling they had breached Financial Fair Play (FFP) regulations but City won an appeal last month to have that verdict and sanction overturned.
Spurs Premier League match at Brighton postponed due to COVID-19
PSG make winning start as Messi arrival looms
Manchester City endured some anxious moments but escaped from fourth-tier Newport County with their FA Cup hopes intact as Phil Foden scored twice in an ultimately comfortable 4-1 fifth-round victory on Saturday.