New coach Julen Lopetegui has been tasked with rebuilding the side following the Portugal forward's departure and the early signs are good, with Real already looking more of a unit than a collection of individuals.
Leaders Barcelona and Real Madrid were held to draws while Sevilla made up ground on the top two and Alaves slipped after a promising start. Here are five talking points from the weekend's La Liga action.
A player in Sevilla's first team squad has tested positive for COVID-19 ahead of their Europa League last-16 tie against AS Roma, the La Liga club announced on Wednesday. The Spanish club said they conducted tests on Sunday on players, coaches and staff. The player, who was not named, is asymptomatic and is self-isolating at home.
Champions Barcelona lost 2-0 at Celta Vigo while Getafe earned an important 2-0 win over Girona in their bid to secure Champions League qualification.
The victory saw the unfashionable Madrid club tighten their grip on the coveted fourth spot in the table by moving on to 58 points after 36 games, three points clear of nearest challengers Sevilla, who lost to Leganes on Friday.
Pires signed for FC Goa in the opening season of the ISL in 2014. However, after a year-long stint with the club, the world-cup winning Frenchman announced retirement.
Late Griezmann strike ends Atletico's away day hoodoo
After an uncharacteristically slow start to the season which provoked questions about his longevity, Cristiano Ronaldo has roared back to life with a torrent of goals and now has La Liga's top scorer award in his sights.
La Liga leaders Barcelona drew 0-0 at Huesca on Saturday and are nine points clear of second-placed Atletico Madrid, who cut the gap by beating Celta Vigo 2-0.
These 5 countries have no airports at all.
New Atletico striker Diego Costa, whose transfer from Chelsea was agreed this week, watched on from the stands as both sides hit the woodwork in the opening 20 minutes of an even first period.
Barcelona's 100 per cent start to the season was ended by Catalonian neighbours Girona, who picked up a draw at the Nou Camp, allowing Real Madrid to take advantage with a victory over Espanyol.
An insatiable Lionel Messi scored for the eighth game in a row in all competitions as La Liga champions Barcelona saw off a gutsy Girona side 2-0 to go five points clear at the top of the standings.
'We are going through difficult and complicated moments and with respect to what could happen in the future we will take it on with calm and wisdom'
In a low-key ceremony, Barcelona and Spain's star mid-fielder, Xavi Hernandez married his girlfriend of one-and-a-half years, Nuria Cunillera, on Saturday.
News of all that's transpired on and off the football field
City Football Group Chief Executive Officer Ferran Soriano said there is no doubt that India will become a major football nation in the coming years.
'There might be other opportunities in Asia. We've been looking at India for nearly two years now. I'd say this year we'll end up doing an investment in India'
Santiago Solari got off to the perfect start as Real Madrid's interim coach when his side thrashed Melilla 4-0 in the Copa del Rey on Wednesday.
La Liga champions Barcelona's domestic struggles continued as they dropped points for the third game in a row, drawing 1-1 at home to Athletic Bilbao on Saturday after Lionel Messi and Sergio Busquets had begun the match on the substitutes' bench.
'It's a prize that's called The Best and the guy who is, for us, the best player in the world wasn't there.'
Manchester City's Abu Dhabi-controlled owner has agreed to sell a $500 million stake to US private equity firm Silver Lake, making it the world's most valuable soccer group with a $4.8 billion price tag.
News of all that's transpired on and off the football field
UEFA announced in a statement that City had committed "serious breaches" of the rules while the Premier League club swiftly said on their website that they will appeal the decision to the Lausanne-based Court of Arbitration for Sport (CAS).
Real Madrid barged their way back into the Spanish La Liga title race with a 3-1 victory over Atletico Madrid in a feisty derby at the Wanda Metropolitano on Saturday.
Barcelona have one hand firmly on the La Liga title after winning 2-0 at Alaves on Tuesday, leaving them 12 points clear at the top of the table with four games to play.
Barcelona have been linked to a host of forwards during the winter transfer window as they seek experienced backup options for Luis Suarez.
Real play Athletic Bilbao while Barcelona visit Real Sociedad in fixtures that have often proved to be among their hardest away trips over the last decade.
Real Madrid have started the season flying with three wins from three games.
Here are five talking points from the weekend's La Liga action:
News of all that's transpired on and off the football field.
After an even first 45 minutes, strikes from Pablo Sarabia and Wissam Ben Yedder stunned the Catalans and left them needing a second-leg comeback at the Nou Camp for the second consecutive round in the competition.
City Football Group will be a 65 per cent majority stakeholder of the club, alongside existing shareholders, actor Ranbir Kapoor and Bimal Parekh, who will keep the remaining 35 per cent.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
'We have to improve and become stronger in defence, which is the most important thing.'
Marco Asensio's strike earned Real Madrid a 1-0 win over Espanyol to send them top of La Liga and Thomas Lemar scored his first goal for Atletico Madrid in a 2-0 victory at Getafe on Saturday.
Barcelona talisman has become just as dangerous from dead ball situations too
News of all that's transpired on and off the football field.