Knee injuries have sidelined him for large parts of this season, however, and the Belgium international has started only four Premier League games.
Manchester City coach Pep Guardiola praised Sergio Aguero's natural goalscoring ability after his hat-trick on Wednesday helped defeat Borussia Moenchengladbach 4-0 in their opening Champions League Group C match at the Etihad Stadium.
News of all that's transpired on and off the football field
A summary of Tuesday's League Cup matches.
Goals rained in for Manchester City and Manchester United but Juergen Klopp's first game in charge of Liverpool was solid rather than spectacular with his new side drawing 0-0 at Tottenham Hotspur in the Premier League on Saturday.
'We lost two games but these two games were totally different. Against Crystal Palace we didn't deserve to lose. Today we deserved to lose the game'
Goals rained in for Manchester City and Manchester United but Juergen Klopp's first game as Liverpool manager was solid rather than spectacular as they drew 0-0 at Tottenham Hotspur in the Premier League.
Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Images from the English Premier League matches played on Saturday
A match by match look at this weekend's English Premier League fixtures.
Leaders Manchester City kept up their unbeaten run with a 3-1 win over Bournemouth on Saturday. Manchester United salvaged a 2-2 draw at Southampton, who sacked manager Mark Hughes on Monday.
If Claudio Ranieri was hoping there might be a player lurking in his reserves to salvage Leicester City's unravelling season he was left disappointed on Saturday as his side were beaten 1-0 by third-tier Millwall in the FA Cup fifth round.
Leicester City have returned to the Premier League for the first time since 2004 despite not kicking a ball on Saturday after Queens Park Rangers and Derby County both lost.
Jose Mourinho will select a strong Chelsea side out of respect to high-flying Championship team Derby County when they meet in the quarter-finals of the Capital One Cup on Tuesday.
However, experienced goalkeeper Joe Hart and Arsenal midfielder Jack Wilshere were both omitted from a squad announced on Wednesday via a social media video featuring young recreational players from around the country shouting out the names.
Records fell on the final day of the Premier League season on Sunday as Manchester City beat Southampton 1-0 to become the first team to reach 100 points and Mohamed Salah established a new Premier League goalscoring mark as Liverpool clinched a top-four spot.
News of all that's transpired on and off the football field
Leicester City were give a Premier League reality check when the unlikely leaders lost 1-0 at Liverpool on Saturday after Manchester United slumped to a third consecutive league defeat to pile more pressure on manager Louis van Gaal.
Manchester City's stellar season gathered yet more momentum as the runaway English Premier League leaders reached the League Cup semi-finals with a penalty shootout victory at Leicester City.
Sunderland striker Jermain Defoe cashed in on a horrendous defensive mix-up to give his struggling side a much-needed 1-0 win at Crystal Palace in the Premier League on Monday.
ManchesterCity moved up to third in the Premier League on Saturday while Newcastle United boosted their hopes of survival by coming back from two goals down at Liverpool to draw 2-2 and secure a precious point.
Manchester City emerged from a trough of despair to beat Tottenham Hotspur 3-1 and move to within three points of the Premier League title at Wembley on Saturday.
Images from the FA Cup matches played on Saturday
News of all that transpired on and off the football field on Friday
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
Only one point separates the two sides with Chelsea on 31 and City on 30 but Antonio Conte's impact at Stamford Bridge appears greater than his City counterpart Pep Guardiola's at the Etihad.
Jose Mourinho, unveiled as Manchester United's new manager on Tuesday, declared he is a winner who aims to return the club to its traditional position of dominance.
England under-21 coach Gareth Southgate looks likely to be put in temporary charge of the national team after the resignation of Roy Hodgson following the side's Euro 2016 exit, British media reported on Wednesday.
Southampton's rich vein of form in the Premier League continued as they beat Burnley 3-1 with two goals from Charlie Austin on Sunday while another promoted side, Middlesbrough, fared just as poorly, losing 1-0 at home to Watford.
Manchester United held on for a goalless draw in a feisty derby with Manchester City after midfielder Marouane Fellaini was sent off for a headbutt in the Premier League clash at the Etihad Stadium on Thursday.
Manchester City thrashed Southampton 6-1 to remain top of the Premier League.
Manchester United manager Louis van Gaal goes into the FA Cup final against Crystal Palace on Saturday facing echoes of the 1990 showpiece between the two sides that proved so pivotal in the career of Alex Ferguson.
Manuel Pellegrini aimed what felt like a surprise parting shot at Manchester City on Sunday by saying his life had been made difficult by the club's decision to announce in February that Pep Guardiola would take over as manager next season.
IMAGES from Saturday's English Premier League matches.
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Ex-Chelsea coach cites past glories behind Jose Mourinho's survival.
News of all that transpired on and off the football field
Cardiff had lost six of their previous seven games but, knowing that anything but a victory would probably end their survival hopes after one season in the top flight, overcame a strong Brighton start to play with growing confidence and fully deserved their victory.
Former Cup winners Coventry, now plying their trade in the bottom division of the Football League, revived memories of happier times as Jordan Willis and Jack Grimmer scored the goals in a 2-1 victory at the Ricoh Arena.
The visitors got off to the perfect start when a mix up at the back saw Riyad Mahrez square for Jamie Vardy to tap into an open goal in front of the Kop in the third minute. Liverpool looked for an immediate riposte, but Salah missed two gilt-edged opportunities before Sadio Mane saw an effort disallowed for offside as Juergen Klopp's men grew frustrated.
