Karim Benzema scored twice after the interval with a penalty and a header from a corner to give Santiago Solari's side a 3-1 lead, after Raphael Varane struck in the 34th minute to cancel out Anuar Tuhami's goal for Valladolid five minutes earlier.
The Belgian forward came off the bench to make his Real debut in Saturday's 3-2 win over Levante, having had his start to life at the club hit by a thigh injury the day before the La Liga season began.
Images from football friendlies played on Wednesday.
How Real Madrid's players reacted to Zinedine Zidane's stepping down as Real Madrid coach.
Liverpool came into Saturday's Champions League final against Real Madrid on a wave of confidence but Zinedine Zidane's side showed exactly why they are the masters of Europe's top club competition in their 3-1 win.
Liverpool thrashed Atalanta 5-0, Real Madrid boosted their chances of reaching the Champions League knockout stages with a 3-2 home victory over Inter Milan and Bayern Munich came from behind to crush RB Salzburg 6-2.
News of all that's transpired on and off the football field.
Barcelona thrashed Sporting Gijon 6-1 to go top of La Liga on a dramatic night in Spain on Wednesday as Luis Enrique announced he was stepping down as the Catalan club's coach at the end of the season.
Teenager Curtis Jones grabbed a 58th-minute winner as an injury-hit Liverpool qualified for the knockout stage of the Champions League with a 1-0 win over Ajax Amsterdam at Anfield on Tuesday.
Real Madrid's 5-0 thrashing of Granada on Saturday equalled a Spanish record of 39 games unbeaten in all competitions. Reuters Sport takes a look at the factors behind their run.
Check out the top footballers of the weekend...
Summary of all that transpired on and off the football field
Images from the Nations League matches.
News of all that's transpired on and off the football field
Real Madrid became La Liga champions for the first time since 2012 on Sunday with a 2-0 win at Malaga, denying arch-rivals Barcelona three consecutive league titles.
A round-up of Saturday's Euro 2020 qualification matches.
England defender John Stones has been ruled out of their final two Euro 2016 qualifiers through injury, the FA said in a statement.
Vietto slotted the ball home with seven minutes to go after Karim Benzema had given visitors Real the lead early on.
Real Madrid got their Champions League title defence off to a strong start on Wednesday by convincingly beating AS Roma 3-0 at home with goals from Isco, Gareth Bale and a stoppage-time strike from returning striker Mariano Diaz.
With the year sprinting to a close, we bring you, in pictures, some of the best action from the sports world.
The result also means second-placed Real Sociedad can reclaim top spot if they beat Eibar on Sunday.
The shadow of their disappointing 2014 World Cup campaign still hangs over Spain as they prepare to defend their European Championship crown in France next month, according to coach Vicente del Bosque.
News of all that's transpired on and off the football field
Images from the Champions League matches played on Wednesday
News of all that's transpired on and off the football field
News of all that transpired on and off the football field
Atletico Madrid tore apart city rivals Real Madrid 4-0 at home to open up the La Liga title race on Saturday in a triumph crowned by a spectacular overhead kick goal by Saul Niguez.
Images from football matches played across Europe on Sunday.
Photos from the La Liga matches played on Sunday
The Portuguese forward then fired in the penalty in the sixth minute of stoppage time.
Europe is preparing for UEFA's first full-blown 'week of football' as the marathon Euro 2016 qualifying competition gets into full swing - although it promises to be a distinctly underwhelming experience.
Real Madrid and Barcelona pulled two points clear in La Liga when Cristiano Ronaldo set a club scoring record in Real's 3-0 stroll against Levante and Neymar hit four as Barca beat Rayo Vallecano 5-2 on Saturday.
Cristiano Ronaldo netted his 27th career hat-trick and Gareth Bale struck twice as Real Madrid bounced back in style from consecutive defeats with a thumping 8-2 La Liga win at Deportivo La Coruna on Saturday.
Barca overcome solid Bilbao challenge to scrape through 1-0.
This and more from the happenings in the world of football
Luka Modric pulled one back for Zinedine Zidane's shellshocked side with a brilliant strike from distance early in the second half before substitute Vinicius Jr reduced the deficit to one goal.
Bigger than ever, the European Championship kicks off in Paris next month with a four-week feast of football that promises to elevate the game above the corruption scandals and security fears that have overshadowed its build-up.
Images from the UEFA Champions League matches played on Tuesday.
Aritz Aduriz scored his first goal for Spain at the age of 35 to give the European champions a fortuitous 1-1 draw away to Italy in a Euro 2016 warm-up for both teams on Thursday.
Images from the Euro 2020 qualifying matches played on Tuesday night.