Liverpool flirted with what would have been an embarrassing low in their poor start to the season as they were taken to penalties by fourth tier Carlisle United, but came through to reach the League Cup fourth round on Wednesday.
Real Madrid's teenage Brazilian duo Vinicius Junior and Rodrygo Goes sent them top of La Liga as both scored in a 2-0 win over Osasuna on Wednesday.
Southampton suffered an embarrassing 1-0 League Cup quarter-final defeat at third tier Sheffield United on Tuesday while Chelsea powered through with a 3-1 win at Derby County.
La Liga leaders Barcelona handed Real Madrid more hope in the title race as they drew 0-0 at Athletic Bilbao on Sunday, only avoiding defeat thanks to some outstanding saves by Marc-Andre ter Stegen.
Newcastle United's controversial director of football Joe Kinnear has quit seven months into a three-year deal after his second spell at the Premier League club in which they made no permanent signings for the first-team squad.
Champions Manchester United beat Premier League leaders Arsenal 1-0 at Old Trafford on Sunday with Robin van Persie once again tormenting his former team mates with a soaring first half header.
Chelsea's woes continued when the holders were dumped out of the Capital One (League) Cup fourth round following a shootout defeat by Stoke City on Tuesday, while Arsenal suffered a humiliating 3-0 defeat at second tier Sheffield Wednesday.
The club anthem Blue is the Colour resounded around a joyful Stamford Bridge and champagne flowed as Chelsea clinched their first Premier League title for five years with a typically stubborn 1-0 victory over Crystal Palace on Sunday.
Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
Chelsea's Jose Mourinho and his old friend Louis van Gaal of Manchester United had different reasons to be satisfied with a point after their teams drew 1-1 in the Premier League at Old Trafford on Sunday.
Wayne Rooney made history by equalling Bobby Charlton's Manchester United record and becoming the club's leading all-time goalscorer after netting his 249th goal (543 matches) during an FA Cup match against Reading on Saturday.
Veteran Drogba showed that he still has a lot of steam in him as he scored in Chelsea's win over Spurs, while Aguero continued to top the goal-scorers' list this season, finding the net for City. Images from the EPL matches played across England on Wednesday.
Schalke 04 halted the Chelsea juggernaut when they drew 1-1 in their Champions League Group G opener at Stamford Bridge on Wednesday, handing a wake-up call to the London club who had won their first four games of the season.
Chelsea's Diego Costa continued his stunning start to life in the Premier League with a hat-trick in a 4-2 comeback win over Swansea City on Saturday that left champions Manchester City staring up the table after a 2-2 draw at Arsenal.
Images from the football matches played across Europe on Sunday
Cristiano Ronaldo bagged his first five-goal haul in Real Madrid's 9-1 hammering of Granada while title-chasing Bayern Munich and Chelsea won again in Germany and England.
La Liga leaders Real Madrid were thumped 4-0 away by city rivals Atletico Madrid to open up the Spanish title race, while Chelsea strengthened their hold on top spot in the English Premier League after a 2-1 win at Aston Villa.
Arsenal maintained their challenge for a first trophy in nine seasons when they beat Liverpool 2-0 at the Emirates Stadium to open up a five-point lead at the top of the Premier League on Saturday.
Chelsea face the prospect of having veteran Didier Drogba as their only fit striker for their visit to Manchester United on Sunday in what is usually one of the standout matches of the Premier League season.
Manchester City returned to the Premier League summit for the first time since January with a 3-2 win at Everton on Saturday that left them six points from a second title in three seasons.
While Lyon rallied to hold Leipzig 2-2 after a Memphis Depay strike, it was the English clubs who made a mark on the night. Liverpool and Chelsea moved into the last 16 with contrasting wins and now all four English clubs, including Manchester City and Tottenham Hotspur, are in the Champions League knockouts this season.
The victory saw the unfashionable Madrid club tighten their grip on the coveted fourth spot in the table by moving on to 58 points after 36 games, three points clear of nearest challengers Sevilla, who lost to Leganes on Friday.
Arsenal and Manchester City meet at The Emirates on Saturday when both teams will seek to roar into life after making spluttering starts to their Premier League campaigns.
Arsenal beat Fulham 2-0 at the Emirates and Manchester City beat Cardiff City 4-2 at the Etihad before Liverpool could only manage a 2-2 draw at Anfield having trailed 2-0.
News of all that's transpired on and off the football field.
La Liga champions Real Madrid beat Getafe 3-1 on Saturday with a goal from Gareth Bale and two strikes from Cristiano Ronaldo to go 12 points behind leaders Barcelona and warm up for next week's Champions League game at Paris St Germain.
News of all that's transpired on and off the football field
Ruthless Bayern Munich scored five goals in the first 35 minutes on the way to a 7-1 demolition of AS Roma on Tuesday which bore an uncanny resemblance to Germany's win over Brazil by the same score in the World Cup semi-final.