Real Madrid's 5-0 thrashing of Granada on Saturday equalled a Spanish record of 39 games unbeaten in all competitions. Reuters Sport takes a look at the factors behind their run.
While Gareth Bale is fully expected to regain his place in the Real Madrid side when he returns from injury, team mate Isco is making the most of his chance to prove his worth on the pitch.
Zinedine Zidane's appointment as Real Madrid coach in place of Rafa Benitez has handed the club's former France great his chance to follow up a stellar career on the pitch with management success at the highest level.
Vietto slotted the ball home with seven minutes to go after Karim Benzema had given visitors Real the lead early on.
Villarreal went top with a 1-0 win over Atletico Madrid on Saturday after a toothless Real Madrid were held 0-0 at home to 10-man Malaga and Lionel Messi suffered a serious injury as Barcelona beat Las Palmas 2-1.
Gijon spoiled Asier Illarramendi's return to Real Sociedad's midfield after rejoining from Real Madrid this week when they held the Basque club, coached by Scot David Moyes, to a 0-0 draw in San Sebastian.
Bastia game abandoned after fans attack Lyon players
Atletico Madrid striker Diego Costa haunted Arsenal again by firing his side to a 1-0 win in Thursday's Europa League semi-final second leg to send the Spaniards into the final and deny Arsene Wenger a dream end to his long reign as Arsenal coach.
Cristiano Ronaldo, Gareth Bale and Karim Benzema took Real Betis apart to give Real Madrid a resounding 5-0 win on Saturday that put them level on 50 points with Barcelona and Atletico Madrid at the top of La Liga.
The enduring image of Luis Enrique for many soccer fans is the Spain player with blood gushing from his nose after a vicious elbow from Italy defender Mauro Tassotti during the 1994 World Cup quarter-final in Boston.
IMAGES from the La Liga matches played on Tuesday
Manchester United humbled Manchester City 4-2 in the continent's big derby of the weekend.
Atletico Madrid tore apart city rivals Real Madrid 4-0 at home to open up the La Liga title race on Saturday in a triumph crowned by a spectacular overhead kick goal by Saul Niguez.
News of all that's transpired on and off the football field
Photos from the La Liga matches played on Sunday
News of all that's transpired on and off the football field
Real Madrid keeper Iker Casillas believes the European champions have a side with the potential to be one of the all-time greats and it will be with likely trepidation that an off-colour Liverpool visit the Bernabeu on Tuesday.
The BCCI has retired the No 10 jersey in Tendulkar's honour. But in football, number 10 signifies the legend. After Pele and Diego Maradona, the two great strikers of the ball, Lionel Messi has made the number priceless, notes Veer Arjun Singh.
Atletico Madrid midfielder Koke is part of a fresh generation of Spain players aiming to make an impact in Euro 2016 qualifying and says he would be happy if he achieves half the success of retired great Xavi.
Sevilla's love affair with the Europa League was immediately rekindled as last season's champions and three-time winners began this year's group stage with a 2-0 home victory over Feyenoord on Thursday.
'More than 95 percent of the players are happy with their contract and happy with their club; they want the kids to go to school, they have a normal life; so I don't think that will happen'
News of all that's transpired on and off the football field
Real Madrid ended their long wait for a La Liga victory by beating Real Valladolid 2-0 on Saturday with two late goals in interim coach Santiago Solari's first home game in charge of the struggling European champions.
English football's biggest club seem to have secured the services of the sport's most colourful manager after Jose Mourinho, according to Sky TV reports, agreed personal terms with Manchester United on Tuesday.
Neymar scored the opener to continue his rich vein of form as 10-man Barcelona won a one-sided La Liga derby against Espanyol.
Porto goalkeeper Iker Casillas, who suffered a heart attack in May, has been registered by the club to play in this season's Portuguese league.
Images from the UEFA Champions League matches played on Tuesday.
The last-16 knock-out round kicks-off this week with Chelsea visiting Paris on Tuesday; Zidane to coach Real Madrid as manager in his first match in Europe
La Liga leaders Real Madrid dropped points at home for only the second time this season.
Real Madrid ensured top spot in La Liga at the midway point of the season when Cristiano Ronaldo struck twice in a 3-0 win at Getafe on Sunday before Lionel Messi's hat-trick helped Barcelona to a 4-0 victory at Deportivo La Coruna.
Having absorbed the body blow of losing striker Radamel Falcao in the close season, Atletico Madrid have emerged as genuine contenders to break the title stranglehold of Real Madrid and Barcelona.
Factbox on the Real Madrid and Portugal forward who was voted FIFA Player of the Year on Monday.
Real Madrid's unbeaten start to the La Liga season came to an abrupt and surprising end as Real Mallorca claimed a stunning 1-0 victory at a rocking Son Moix on Saturday to climb out of the relegation zone.
Luis Suarez struck twice and Lionel Messi scored on his 500th appearance for Barcelona who set a new Spanish record of goals in a calendar year with a 4-0 win over Real Betis that lifted them top of La Liga on Wednesday.
Griezmann special earns Atletico 1-1 draw at Sevilla
Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
News of all that's transpired on and off the football field
Real Madrid winger Gareth Bale answered his critics in emphatic style.
The three teams with 100 percent records in this season's Champions League can secure their places in the knockout stage this week with two games to spare.
Jose Mourinho suffered a nightmare homecoming as Porto, the club he led to the Champions League title in 2004, inflicted a 2-1 defeat on his woefully out-of-sorts Chelsea side in Group G on Tuesday.