Medvedev opened as the +225 favorite at BetMGM but has seen his odds lengthen slightly despite the absence of two of his top threats. He has had a rollercoaster 2022 since falling to Nadal in the Australian Open final.
'Rarely did I feel my best on clay in the first or second tournament in the season. That was the case this season again. It took me two tournaments to really feel that I'm getting closer to the desired level.'
The Australian Open champion never faced a break point and used her hard and accurate serve to dispatch Gauff.
Having lost both the singles on the opening day, the Yuki-Saketh pair did put up a fight before losing to the fancied Norwegian duo in an hour and 50 minutes.
'I'm disappointed and sad because after a good start to the season I was coming to a very important part of the year with very good feelings and good results.'
Images from Sunday's action in the Premier League.
A summary of Saturday's action at the US Open.
Novak Djokovic produced a stunning performance to thrash Frances Tiafoe in his first match since winning Wimbledon in July to edge Team Europe ahead in the Laver Cup on Saturday.
Zverev will have a chance to spoil the birthday party for Nadal, who turns 36 on Friday
Novak Djokovic beat Casper Ruud in the French Open final to win a men's record-extending 23rd Grand Slam title.
How sweet it is: Eubanks's climb up the ranks is 'icing on the cake'
Zverev won in four sets at Roland-Garros to send Alcaraz packing and reach the French Open semi-finals for a second straight year.
Norrie's semi-final opponent will be another American, fourth-seeded Tommy Paul, who crushed Stefan Kozlov 6-3, 6-1 in an all-US matchup.
Images from the English Premier League matches played on Saturday.
Jabeur advances to first WTA 100 final in Madrid in style.
Djokovic first played Monfils at the US Open in 2005 but Tuesday's match was only their second encounter on clay and he needed only one break point to clinch the first set.
A summary of Monday's action at the US Open.
Medvedev suffered a jarring early exit from the Canadian Masters last week but overcame some initial problems in a tricky tie against Shapovalov to edge both sets and book a meeting with American Fritz.
A day after taking down world number one Carlos Alcaraz of Spain, Felix Auger-Aliassime booked Canada's place in the Davis Cup quarter-finals on Saturday with a 6-3, 6-4 win against Serbia's Miomir Kecmanovic in the group stage tie in Valencia.
IMAGES from Day 5 of the Wimbledon Championships at All England Lawn Tennis and Croquet Club on Friday.
10 Interesting Glimpses from the French Open.
IMAGES from Day 2 of the US Open played at Flushing Meadows in New York on Tuesday.
A round-up of all tennis action on Saturday.
'I LOVE YOU, Roger. Thank you for everything you've done in tennis and with myself. Tennis world will never be the same without you.'
Images from Day 5 of the 2021 US Open in New York on Friday.
Images from the English Premier League matches played on Saturday.
Holder Stefanos Tsitsipas moved into the Monte Carlo Masters quarter-finals with a 7-5 7-6(1) victory over Laslo Djere
Images from Day 6 at the French Open, at Roland Garros, in Paris, on Friday.
IMAGES from Day 8 of the French Open at Roland Garros on Sunday.
Images from the 2022 Wimbledon Championships at the All England Club in London on Sunday.
Images from Day 3 of the 2022 Australian Open in Melbourne on Wednesday.
A summary of Tuesday's action at the US Open.
Pole says she feels much better prepared to handle the pressure of her latest career milestone.
Images from Day 7 of the 2021 US Open in New York on Sunday.
Rafael Nadal toppled big-serving American Reilly Opelka to remain perfect on the year while unseeded Serbian Miomir Kecmanovic stunned world number six Matteo Berrettini.
Daniil Medvedev lost his world number one ranking after being defeated by Gael Monfils
Images from Day 9 of the 2021 US Open in New York on Wednesday.
Thousands of mask-free spectators flocked into the stadium
Thiem, Wawrinka stay positive after defeats on return
Shapovalov will meet Rafael Nadal for a place in the semi-finals.