Only two teams -- Chelsea in 2005-06 and Manchester City last season -- have had more points after 18 Premier League games in a season than Liverpool's 48.
Atalanta's Josip Ilicic and Robin Gosens scored quickfire second-half goals to give them a comfortable 2-0 win over a toothless Liverpool
This time Liverpool are at home, and victory would put them nine points clear.
IMAGES from the Champions League matches played on Tuesday.
Winter returned to Anfield on Friday but while the temperature dropped, the standards of Juergen Klopp's side certainly did not as Sadio Mane and Mohamed Salah both struck twice in a 5-0 thrashing of relegated Huddersfield Town.
Liverpool had been the better side for great swathes of the Premier League encounter at Stamford Bridge, but a combination of poor finishing and resilient Chelsea defending meant they entered the dying minutes trailing 1-0 to Eden Hazard's superb finish.
Premier League champions Liverpool maintained their 100 per cent start to the season with a 3-1 win against Arsenal at Anfield on Monday leaving them level on nine points with pacesetters Everton and Leicester City.
Images from Saturday's action in the Premier League.
However, one goal proved enough for City who picked up their sixth successive league win to move four points clear of Liverpool, who host Aston Villa later on Saturday, at the top of the standings.
Liverpool opened up an eight-point lead at the top of the Premier League with an emphatic and hugely impressive 3-1 win over defending champions Manchester City.
A round-up of Saturday's matches in the English Premier League.
Photos from the Premier League matches played on Sunday
News of all that's transpired on and off the football field
Roberto Firmino struck a stoppage-time winner as Liverpool beat Paris St Germain 3-2 at Anfield on Tuesday after Kylian Mbappe looked to have secured a point for the French side in a compelling Champions League Group C clash.
It was not so much the maths, though Liverpool's nine-point advantage over defending champions City, with one point less over Leicester City and Chelsea, is a significant gap, especially as Juergen Klopp's side have lost one league game in 18 months.
A last-minute own goal gave Liverpool a 2-1 win over Tottenham Hotspur to keep them top of the Premier League but Manchester City stayed two points behind having won at Fulham. Huddersfield Town were relegated after their defeat by Crystal Palace.
IMAGES from the English Premier League matches played on Sunday.
Images from the Champions League football matches played on Wednesday night.
Virgil van Dijk made a dream start to his Anfield career, scoring the winning goal on his debut for Liverpool, as they beat city rivals Everton 2-1 in a pulsating FA Cup third round tie on Friday.
A Roberto Firmino hat-trick proved the highlight of Liverpool's 5-1 demolition of Arsenal as the Premier League leaders opened a nine-point gap over Tottenham Hotspur, who lost 3-1 to Wolverhampton Wanderers.
Records fell on the final day of the Premier League season on Sunday as Manchester City beat Southampton 1-0 to become the first team to reach 100 points and Mohamed Salah established a new Premier League goalscoring mark as Liverpool clinched a top-four spot.
IMAGES from the English Premier League matches played on Wednesday
Images from Sunday's Premier League matches.
Liverpool moved into the Champions League qualifying spots after a 3-0 win at Burnley on Wednesday took them above Leicester City and into fourth place with one round of Premier League matches remaining.
A hat-trick by in-form Scotland midfielder James Forrest earned them a 3-2 home win over Israel in the Nations League and promotion to the competition's second tier on Tuesday.
Images from English Premier League matches played on Sunday.
Pogba suffered the injury in United's 3-0 Champions League win over Basel this month.
Liverpool reached the Champions League semi-finals for the first time in 10 years as Mohamed Salah and Roberto Firmino struck decisive blows to secure a 2-1 win over Manchester City on Tuesday that completed a 5-1 aggregate victory.
After falling 2-0 down on the night, substitute Marcos Llorente struck twice in extra-time and Alvaro Morata added a late third to ensure a famous victory for Diego Simeone's side against a Liverpool team unbeaten in their last 25 home games in European competition.
Liverpool thrashed Atalanta 5-0, Real Madrid boosted their chances of reaching the Champions League knockout stages with a 3-2 home victory over Inter Milan and Bayern Munich came from behind to crush RB Salzburg 6-2.
Images from the EPL matches played on Sunday
Images from the English Premier League matches played on Sunday.
Liverpool's livewire Sadio Mane scored one goal and played a crucial part in the other as they reclaimed the Premier League's top spot with a scrappy 2-1 win at second bottom Fulham on Sunday.
Real Madrid face Liverpool in the Champions League final in Kiev. Below are five key tactical factors that could affect the outcome of Saturday's match.
The pain of missing out on a first domestic league crown for 29 years will be eased by the knowledge that European glory could be on the horizon for Liverpool
Spaniard Pedro scored twice as Chelsea tightened their grip on top spot by sweeping past Bournemouth 3-0 on Monday, a club record 12th successive Premier League win taking them seven points clear.
Barcelona were held to a frustrating 0-0 draw at Olympique Lyonnais in their Champions League last-16 first leg on Tuesday as both sides remained unbeaten in this season's competition.
News of all that's transpired on and off the football field
IMAGES from the English Premier League match played on Saturday
This and more from the happenings in the world of football