The duo of B Sumeeth Reddy and N Sikki Reddy entered the mixed doubles second round but the other Indian shuttlers, including Priyanshu Rajawat, made early exits
Two-time Olympic medallist Sindhu will next play Japan's Natsuki Nidaira, while Sen will be up against Ygor Coelho of Brazil.
Double Olympic medallist PV Sindhu, Commonwealth Games gold medallist Lakshya Sen, Tokyo Olympic B Sai Praneeth and Ruthvika Shivani Gadde will be in action later on Wednesdat.
Priyanshu Rajawat suffered a 13-21, 14-21, loss to Japan's Kanta Tsuneyama, while Aakarshi Kashyap went down 18-21, 10-21 to German Yvonne Li.
P V Sindhu and Lakshya Sen progressed to the quarter-finals at the Canada Open Super 500 tournament
Sindhu, Lakshya win openers; Sai Praneeth loses in US Open
Newly-crowned Canada Open champion Lakshya Sen will hope to continue his winning momentum while beginning his campaign at the US Open Super 300 badminton tournament.
Vietnam Open: Simran-Ritika in quarters.
Tokyo Olympian B Sai Praneeth will lock horns with Japan's Koki Watanabe, while Sourabh Verma faces France's Toma Junior Popov.
This is the third time this year that Sindhu has been knocked out in the first round of the tournaments she's played.
The Indian men's team is searching for its maiden medal at the tournament. No Indian men's team has ever reached the semi-finals of the Thomas Cup.
With the main draw of the Asian Badminton Championships set to get underway from Wednesday, the struggling Indian shuttlers face an uphill task.
The top seeded Indian duo, who reached the semi-finals of the season-opening Malaysia Open super 1000, was scheduled to face Chinese Taipei's Su Ching Heng and Ye Hong Wei in the opening round.
Saina Nehwal produced a fine performance to kick-off her BWF World Championships campaign with a straight game win over Hong Kong's Cheung Ngan Yi.
Tokyo Olympian B Sai Praneeth will meet compatriot HS Prannoy in his opening match, while former Commonwealth Games champion Parupalli Kashyap will square off against a qualifier.
If Sindhu and Saina win their respective second round matches, they will face each other in the quarter-finals.
Ishaan and Sai Pratheek took just 30 minutes to get the better of English duo
Lakshya Sen, returning from a break, suffered a first round exit, while Treesa Jolly and Gayatri Gopichand entered the pre-quarters of the Asia Badminton Championship.
The Indian men's badminton team scripted a memorable 3-2 win over Malaysia to enter the semifinals of Thomas Cup for the first time in 43 years
Sindhu, a 2019 World Champion, lost 14-21, 21-15, 14-21 to Zhang in a match that lasted 55 minutes.
His backhand blocks and forehand low returns reaped dividends but an alert Gemke managed to grab a four-point cushion at the interval.
Brimming with confidence, India will again look to punch above their weight when they run into 14-time winners Indonesia in the final of Thomas Cup in Bangkok on Sunday, seeking to create history one more time.
India has entered the final of the Thomas Cup for the first time since the tournament began 73 years back.
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