Liverpool did not reveal the transfer fee but Southampton announced it was "a new world-record for a defender" with English media reporting that it was a 75 million pounds ($100.49 million) deal.
Tim Sherwood's hopes of becoming Tottenham Hotspur's next permanent manager were boosted after his attacking team came back to win 3-2 at stuttering Southampton in an enthralling Premier League encounter on Sunday.
Chelsea opened up a six-point lead at the top of the Premier League despite being held to a 1-1 draw against top-four hopefuls Southampton in an absorbing game at Stamford Bridge on Sunday.
Man City to face Spurs in League Cup
The result leaves Southampton, now winless in their last nine games, 19th in the 20-team English Premier league.
IMAGES from the Premier League matches played on Saturday.
Southampton missed a penalty as they held a makeshift Manchester United side to a 0-0 draw in a tepid Premier League clash on Wednesday.
Chelsea's fading Premier League title hopes suffered another unexpected blow when Southampton fought back from 2-0 down to draw 2-2 with the European champions on Wednesday.
'Hopefully, he will be back from his injuries soon. The priority will be the Champions Trophy, so we are going to make sure he is ready for that.'
Liverpool ran riot to reach the League Cup semi-finals with a 6-1 thrashing of Southampton on Wednesday in which Divock Origi grabbed a hat-trick and Daniel Sturridge scored twice as the Juergen Klopp juggernaut rolled on.
Images that should keep you grinning for days on end.
Chelsea maintained their iron grip on top spot with a 2-1 win at Crystal Palace while Southampton recorded one of the biggest victories in Premier League history when they crushed a woeful Sunderland side 8-0 at St Mary'son Saturday.
Anthony Martial and Zlatan Ibrahimovic scored twice each to help Manchester United ease into the League Cup semi-finals with a 4-1 home victory over West Ham United on Wednesday as Arsenal suffered a 2-0 home defeat by Southampton. Martial netted twice in the second half to take the tie at Old Trafford away from West Ham, who had levelled through Ashley Fletcher following Ibrahimovic's opener after two minutes. The Swede added the fourth deep into stoppage-time.
Manchester City overcame a spirited Bournemouth side 3-1 on Saturday to maintain their unbeaten streak and extend their lead at the top of the English Premier League to five points.
Moises Caicedo's blistering second-half strike cancelled out a Bruno Fernandes penalty as Chelsea salvaged a 1-1 draw with Manchester United on Sunday.
Manchester United spurned a chance to move into the Premier League's top four after striker Zlatan Ibrahimovic missed a penalty in a 1-1 draw against 10-man Bournemouth on Saturday.
Michael Owen and Javier Hernandez scored second-half goals as Manchester United fought back to beat League One (third division) Southampton 2-1 in their FA Cup fourth-round tie at St Mary's on Saturday.
Israel debutant Yarden Shua scored an 86th-minute winner as they upset more fancied Belgium 1-0 in Budapest on Sunday.
Images from the second T20 International between England and Australia, at Sophia Gardens Cricket Ground, Cardiff, Wales, on Friday.
Championship side Derby County hit back from two goals down to beat Premier League Southampton on penalties in an FA Cup third-round replay marred by another VAR controversy on Wednesday.
A 3-0 reality check at the hands of Manchester City was always a moment waiting to happen for Southampton. Just how they bounce back from Sunday's defeat may now determine their fortunes this season.
Lord's, the 'home of cricket', will host its first-ever Women's Test between India and England in 2026, the ECB announced on Thursday.
Swansea City came from behind to end Manchester United's unbeaten start to the Premier League season with an impressive 2-1 victory at the Liberty Stadium on Sunday.
Jose Mourinho has confirmed that record signing Paul Pogba is ready to make his second Manchester United debut when Southampton visit Old Trafford in the Premier League on Friday.
Chelsea put a miserable week behind them to return to the Premier League summit with a 2-0 win over Fulham as the wheels came off Liverpool's bright start in a 1-0 home defeat to Southampton on Saturday.
Southampton's barnstorming start to the Premier League season has been reflected in a trio of nominations for early-season awards. Dutchman Ronald Koeman has been nominated for the Premier League Manager of the Month award.
Statistical highlights of the second day's play in the third cricket Test between India and England in Southampton on Monday.
Liverpool cruised into the fifth round of the FA Cup with a 5-2 rout of Championship side Norwich City on Sunday, to kick off Juergen Klopp's long goodbye at Anfield.
Arsenal coach Arteta has said that Granit Xhaka will stay at the London club while United have new headaches with injuries to Paul Pogba and Scott McTominay.
Bristol Rovers got the FA Cup fifth round underway with an upset on Saturday when Rickie Lambert's late free kick gave the League One (third division) side a 1-0 win over Championship (second division) Southampton.
The patched-up backline will come up against an erratic Serbia with an experienced attack led by Aleksandar Mitrovic, who notched 28 goals in 28 matches in the Saudi Pro League and is a major threat in the air.
Southampton suffered an embarrassing 1-0 League Cup quarter-final defeat at third tier Sheffield United on Tuesday while Chelsea powered through with a 3-1 win at Derby County.
Navendu Mishra (Stockport) and Nadia Whittome (Nottingham East) were among the other Labour MPs re-elected with convincing majorities.
Johnson sidelined for Aus tour of UK
A tough day awaits India as they brace up against the fiery England bowling on the fifth and final day of the third Test at the Ageas Bowl in Southampton on Thursday.
Brazilian Casemiro struck late to send Manchester United into the FA Cup quarter-finals with a 1-0 victory over Nottingham Forest as teenagers Jayden Danns and Lewis Koumas inspired Liverpool to a 3-0 win over Southampton on Wednesday.
Leeds reach Championship play-offs final with 4-0 win over Norwich
Cesc Fabregas and Branislav Ivanovic struck late goals to earn improving champions Chelsea a 2-1 victory at Southampton in the Premier League on Saturday.
Images from the English Premier League matches played on Saturday
"It's not much better at the moment. With Daniel's injury we have to take it day by day, and see if he's better," Klopp told a news conference on Friday.