Next up for the 35-year-old will be another American in 39th-ranked Tommy Paul with a potential semi-final clash against top-seeded Russian Daniil Medvedev, who he defeated in the Australian Open final from a two-sets deficit.
Djokovic had been favourite to win a 10th title at Melbourne Park and claim a 21st Grand Slam crown but the Serb now faces being deported from Australia.
World number one Novak Djokovic earned his 1,000th tour-level victory by beating Casper Ruud 6-4, 6-3 on Saturday to reach the Italian Open final.
Djokovic's family said his release was the 'biggest victory of his life'.
The Australian government cancelled Novak Djokovic's visa for a second time on Friday, saying the World No 1, unvaccinated for COVID-19, may pose a risk to the community.
Novak Djokovic blamed "human error" on Wednesday for a mistake in his Australian immigration paperwork and apologised for breaking isolation for a photoshoot when he had COVID-19 last month.
Immigration Minister Alex Hawke's office said he was still considering whether to use his discretionary power to cancel Novak Djokovic's visa.
Indian Wells organisers said on Tuesday that world number two Novak Djokovic had been placed in the tournament's draw but it was unclear if the Serbian would be permitted to enter the United States.
A round-up of all tennis action on Friday.
Her last Grand Slam triumph came in 2017 and she has not won a WTA title since lifting the ASB Classic in Auckland at the start of the 2020 season.
The Serbian champion said he hoped the focus would now return to tennis
Divij Sharan and his Serbian partner Nikola Cacic fought hard before going down in three sets
Images from Day 6 at the French Open, at Roland Garros, in Paris, on Friday.
Natasa Stankovic shared an adorable photo with her son Agastya.
The Serbian government has imposed a daily 5 p.m. to 5 a.m. curfew during weekdays and a more stringent weekend ban starting at 1 p.m. on Saturdays till 5 a.m. on Mondays in order to curb the spread of the virus. Serbia striker Aleksandar Prijovic was arrested for violating the Balkan nation's coronavirus curfew.
The tournament initiative was to launch on Wednesday - Ukraine Independence Day - with the exhibition event at Louis Armstrong Stadium
World number one Novak Djokovic was released from Australian immigration detention on Monday after winning a court challenge to revive his bid to win a record 21st Grand Slam title at the upcoming Australian Open.
AELTC took the decision in the wake of Russia's invasion of Ukraine
Nadal has won the Australian and the French Open back-to-back and has the chance to become the first man to win all four majors in the same year
The Spaniard's withdrawal means Medvedev will be top seed at the March 1-7 event, which also features top-10 players Stefanos Tsitsipas and Alexander Zverev.
Australia's Nick Kyrgios said he supported vaccination "but how we are handling Novak's situation is bad, really bad". The Australian Open begins on January 17, but the multi-millionaire Djokovic is constrained from training as he sits in a hotel where one Iranian detainee said he had found maggots and mould in the bread.
Novak Djokovic has pulled out of the Serbia team for the ATP Cup in Sydney, event organisers said on Wednesday, raising further doubts over whether the world number one will defend his Australian Open title next month.
The 31-year-old triumphed despite suffering from an apparent muscle problem to became the lowest seeded player, at 13, to claim the title since Gustavo Kuerten in 1999.
Hardik and actor Natasa Stankovic have named their baby boy Agastya.
Novak Djokovic has only faced Nick Kyrgios twice in his career, losing twice to him in 2017, so while he will be favourite to claim a seventh Wimbledon crown, he knows exactly how dangerous the unpredictable world number 40 Kyrgios can be.
Rafael Nadal toppled big-serving American Reilly Opelka to remain perfect on the year while unseeded Serbian Miomir Kecmanovic stunned world number six Matteo Berrettini.
The Russian ended Djokovic's hopes of completing a sweep of all four Grand Slam titles in 2021 when he defeated the Serb in the US Open final in September to pick up his maiden major.
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
'Hardik and I have shared a memorable journey together so far and now, it's only going to get better together,'
The Serbian's 1-6, 6-3, 6-1 defeat also ended his dream of winning an Olympic singles gold medal, the only major honour missing from his long list of accolades.
'... at times when I see the aftermath of things, I do tend to ask myself if I should just sit back and enjoy my benefits instead of paying attention to other people's struggles.'
Novak Djokovic enjoyed success at his own tennis centre when he won the Belgrade Open with a 6-4, 6-3 win over Slovakian Alex Molcan in Saturday's final.
'Is he serious? It's a selfish political move to gain popularity.'
Thousands of mask-free spectators flocked into the stadium
Manchester United midfielder Nemanja Matic has defended his Serbian compatriot Novak Djokovic for hosting the ill-fated Adria Tour where a number of players, including the world number one, tested positive for COVID-19. Djokovic was criticised for hosting the tennis tournament amid a pandemic after his coach Goran Ivanisevic and players Grigor Dimitrov, Borna Coric and Viktor Troicki returned positive tests over the two legs in Serbia and Croatia.
Djokovic was deported from Australia, just hours after the court dismissed his effort to stay in the country to play at the Australian Open
Hardik Pandya shared an adorable picture on Instagram in which he is seen bringing the diapers for the newborn baby.
Federer is tied with Rafael Nadal and Novak Djokovic in the race to be the most successful men's singles Grand Slam champion of all time and Australian Open organisers would have been hoping to have all three at Melbourne Park.
Daniil Medvedev's bid to reclaim the world number one ranking fell short on Thursday as the Russian lost 7-6(7), 6-3 to Poland's Hubert Hurkacz in the Miami Open quarter-finals.
The reaction has been swift across the world to Novak Djokovic's visa has been cancelled for a second time by the Australian government.