Following is a match by match look at the English Premier League's season-opening weekend fixtures:
The result leaves Ole Gunnar Solskjaer's United in 10th with nine points, their worst start after seven games for 30 years, and they have won just one of their last six league games.
A summary of Sunday's Premier League matches.
In a gripping title race, Liverpool showed they are ready to push Manchester City right until the final seconds of this season with their spirited 3-2 win at Newcastle United.
Images from the English Premier League matches played on Saturday.
Wilfred Ndidi netted a dramatic late equaliser on Saturday to help Leicester City secure a 1-1 draw with West Ham United, who played more than half the game with 10 men after Mark Noble was shown a straight red card.
City are looking to retain the title they won in record-breaking fashion last year and secure their fourth Premier League crown in eight years.
Klopp says Liverpool's defending to blame for loss
Juergen Klopp's side, chasing their maiden title in the Premier League era and first in the top flight in 30 years, took a 14th-minute lead from a Virgil van Dijk header but had to wait until stoppage time to put the game to bed through Mohamed Salah.
IMAGES from the English Premier League matches played on Saturday.
Liverpool regained their place at the top of the English Premier League with a 2-0 win at Cardiff City on Sunday that restored their two-point lead over Manchester City
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Tottenham Hotspur's exhilarating Premier League title surge came to a shuddering halt as they lost 1-0 at West Ham United on Friday to leave Chelsea needing six points from four games to be crowned champions.
The Argentine scores a hat-trick to become the highest foreign goal scorer in the Premier League on Sunday. Also, in bagging a 12th Premier League hat-trick he surpassed the 11 of Alan Shearer with whom he had shared the record.
An own goal by Stoke City keeper Jack Butland gifted Leicester City an equaliser in a 1-1 Premier League draw at the King Power Stadium on Saturday and denied Paul Lambert's side a rare win on the road.
Whatever happens, there will be no shortage of drama between now and May 12.
IMAGES from the English Premier League matches played on Wednesday
'I want to say I was convinced even before (the defeat by Chelsea in February's FA) Cup match that controlling the two players that play behind Diego (Costa) and controlling the full-backs, because they go really deep with two wide men, would create lots of problems and I repeat the same'
Arsenal coach Arteta has said that Granit Xhaka will stay at the London club while United have new headaches with injuries to Paul Pogba and Scott McTominay.
Tottenham Hotspur are favourites to win the Premier League this season according to table-topping Leicester City manager Claudio Ranieri, because their title charge has virtually gone under the radar.
Chelsea came from behind to secure a 3-1 win at Manchester City and forge further clear at the top of the Premier League as a dramatic top-of-the-table clash ended in a mass brawl and two City players being sent off on Saturday.
Tottenham Hotspur have the chance to exert psychological pressure on Premier League leaders Chelsea when they open the weekend programme at home to Watford on Saturday.
The two previous meetings at Anfield ended in 4-0 and 3-1 defeats for Arsene Wenger's Arsenal teams, but there is a fresh optimism around the club after a successful transfer window.
Liverpool manager Juergen Klopp has dismissed claims that it is the perfect time to face Tottenham Hotspur because of injuries to key players and concern over striker Harry Kane's form and freshness.
Strong start bodes well for Spurs' title hopes, says Lee
IMAGES from the English Premier League matches played on Sunday
Raheem Sterling scored a hat-trick as champions Manchester City made a convincing start to their title defence with a 5-0 win over West Ham United.
But it was not all good news for Mourinho, as substitute Marcus Rashford was sent off in the 71st minute for pushing his forehead into Phil Bardsley's head.
Chelsea may still take their case to the Court of Arbitration for Sport, as other clubs have done in the past.
Bernardo Silva has made an encouraging start to the Premier League campaign and the Manchester City midfielder said that feeling more settled at his second season with the champions was a key factor in his performances.
Sergio Aguero netted his 13th hat-trick for Manchester City as the champions made light of the absence of the injured Kevin De Bruyne to thrash Huddersfield Town 6-1 and move joint top of the Premier League.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
Manchester United continued their push for a top-four finish with a comfortable 3-0 victory at champions Leicester City on Sunday, extending their unbeaten Premier League run to 15 games.
Premier League leaders Liverpool suffered 12 separate injuries this season to players that took part in last year's World Cup in Russia, compared to 27 for title rivals Manchester City, according to a report published on Wednesday.
Chelsea manager Jose Mourinho believes that not having another international break until March will help his team recapture their best form after a woeful start to the season.
"After feeling strange in the second half of the Burton game in September, I underwent a series of tests," he said.
Arsenal manager Arsene Wenger has blamed his side's poor finish as the reason behind their goalless draw against Southampton in their Premier League clash at the Emirates Stadium.
Reigning champions Manchester City took the lead after 24 seconds but suffered a shock 2-1 defeat at Newcastle United.
Images from the EPL matches played on Saturday
'It's like now with Lamela or Vertonghen, how you sit in the chair and cry because you miss someone... But the competition does not allow you to cry. You have to move on quick. It's a bit cruel, but you have to move on and try to win the next game'
