The 32-year-old, who has not played since retiring injured in the US Open semi-finals, cited an abdominal injury.
The 21-year-old German, one of the brightest stars in men's tennis, is yet to progress beyond the quarter-finals at a Grand Slam.
IMAGES from the matches played at the PNB Paribas Open at Indian Wells on Wednesday
The 36-year-old was all over the world number 58 throughout a one-sided contest under the Rod Laver Arena roof, breaking three times to win the opening set in 33 minutes.
Nightmares loom for players dreaming of Grand Slam success if they have the misfortune of running into bespectacled bogeyman Chung Hyeon in coming years, according to his coach Neville Godwin.
Djokovic, the ninth seed, was originally scheduled to play Australian Open semi-finalist Chung Hyeon but the 22-year-old South Korean withdrew with a back injury about an hour before the match was due to start.
Novak Djokovic claimed a fourth Wimbledon title in ruthless fashion as he beat giant South African Kevin Anderson 6-2, 6-2, 7-6(3) in the final.
Serbia's Novak Djokovic, who beat Switzerland's Roger Federer to win his 16th Grand Slam title on Sunday:
Two time Miami Open winner Victoria Azarenka crushed Serbia's Jelena Jankovic.
World number one Novak Djokovic is a red hot favourite to overcome all opponents and clinch another Australian Open title this year, although extreme temperatures will be a wild card the Serb has to watch out for.
Far from being a fading force, 12-times Grand Slam champion Novak Djokovic has shown signs that he is emerging from the toughest spell of his career and is ready for a fresh start ahead of next week's French Open.
Madison Keys beat fellow American CoCo Vandeweghe for the second time in eight days with a 6-4, 3-6, 6-3 victory on Monday to reach the second round of the Cincinnati Open.
This is the first time that the towering Croatian has made the final of the Aus Open
Djokovic, who has ruled like no other on Rod Laver Arena simply had no answer as Chung, nine years his junior, wore him into the ground to win.
Novak Djokovic said an approach had been made offering him $200,000 to throw a match at the St Petersburg Open.
Serena faces hard-hitting Giorgi in first round while former World No Hewitt play his final grand slam
Former US Open champion Del Potro fired down 11 aces and did not face a break point during the one hour, 33 minutes match.
Sealing the match with a thumping serve, the 2014 US Open champion will bid for his second grand slam title against Friday's winner of Roger Federer and South Korea's rising star Chung Hyeon.
Factbox on Serbia's Novak Djokovic who won his sixth Australian Open men's singles title on Sunday.
IMAGES from the matches played at the Miami Masters on Sunday
South Korean Chung Hyeon managed to hang around against Roger Federer a little longer this time around, but only just, as the Swiss maestro advanced to the semi-finals of the BNP Paribas Open 7-5, 6-1 on Thursday.
While Federer and Nadal will look to reignite the flair and fight they showed to reach last year's final, 2018 could have a different script at play.
IMAGES from the Miami Masters played in Key Biscayne, Florida on Tuesday
Photos from Day 1 of the Australian Open matches played at Melbourne Park on Monday
Mischa still finds time to tease 'Sascha', despite his little brother's rapid ascent up the tennis rankings.
Wozniacki battles past Kerber into Eastbourne final
Japan's Kei Nishikori, who will arrive at Roland Garros without an ATP title for more than two years and desperate to prove that his career has not already peaked.
IMAGES from the PNB Paribas Open played at Indian Wells in California on Monday
Images from Day 3 of the Australian Open in Melbourne on Wednesday.
IMAGES from the matches played at Miami Miasters in Key Biscayne, Florida, on Wednesday
A summary of sports events and sports persons, who made news on Friday.
Simona Halep and Stan Wawrinka beat the heat with straight-sets wins to reach the third round of a sweltering US Open on Thursday while American hope Jack Sock wilted under the punishing conditions, collapsing on court.
Images from the Australian Open in Melbourne on Thursday.
Milos Raonic overcame third seed Grigor Dimitrov 7-5, 3-6, 6-3 to reach the third round at the Madrid Open on Tuesday and set up an all-Canadian clash with teenager Denis Shapovalov.
Images from the matches played on Day 8at the Roland Garros on Sunday
Sania, the country's finest woman doubles player, who began the year with the number one ranking, closed it at number 9.
Images from the matches played on Day 7 at the Roland Garros on Saturday
Images from Day 5 of the French Open in Paris on Thursday.
A summary of Thursday's play at the US Open.
Factbox on Serbia's Novak Djokovic and Great Britain's Andy Murray who will contest his sixth Australian Open men's singles final on Sunday.