The Spanish soccer federation (RFEF) said on Tuesday Messi had been banned for two matches, meaning he will miss Thursday's Copa del Rey last-32 tie at Cornella and Sunday's La Liga match away to Elche.
Inaki and Nico Williams encounter contrasting fortunes at the World Cup.
Bayer Leverkusen beat Freiburg 3-2 to edge closer to a first ever Bundesliga title.
Real Madrid's Rodrygo struck twice and Jude Bellingham was also on target as the visitors enjoyed a 3-0 win at lowly Cadiz.
Photos from soccer matches played across top European Leagues on Saturday.
'Yesterday, he trained normally, and today he's taken this decision. We have accepted it. I spoke to him this morning, and he said he was leaving, and I understood.'
Granada and Bilbao complete match suspended after supporter's death
Athletic Bilbao beat Barcelona 4-2 at home to knock them out of the Copa del Rey
Villarreal's struggles in the Spanish league continued with a 2-1 loss at Athletic Bilbao, with striker Gerard Moreno not finishing the game because of an injury.
A tenacious Barcelona frustrated Real Madrid to secure a 1-0 win over their bitter rivals in an ill-tempered Copa del Rey semi-final first leg on Thursday.
Karim Benzema and Vinicius Jr. scored in extra time as Real Madrid fought back to beat local rivals Atletico 3-1 and reach the Copa del Rey semi-finals.
Barcelona's Sergi Roberto and Robert Lewandowski struck just before halftime to give the league leaders a 2-0 home win over lowly Cadiz on Sunday in their pursuit of a 27th Spanish title.
Real Madrid thrashed arch-rivals and league leaders Barcelona 4-0 to reach the Copa del Rey final
Barcelona winger Raphinha secured a 1-0 win in LaLiga for the second straight week this time at Athletic Bilbao as his side tightened their grip on top spot.
Brazil lived up to expectations by smashing Bolivia 5-1 at home in their 2026 World Cup qualifiers opener on Friday.
In his absence, the league champions have made a lacklustre start to the season, losing their opening game to Athletic Bilbao before taking just four points from fixtures against Real Betis and Osasuna.
Hazard extra-time goal sends 10-man Real Madrid through to Copa del Rey final.
Here are five talking points from the weekend in La Liga:
Sevilla, winners of the Europa League for the past two years, will play Shakhtar Donetsk in this season's semi-final.
Real Sociedad won 1-0 at Athletic Bilbao in a Basque Country derby to end its winless run and strengthen its hold on third place in the Spanish league
Stakeholders are confident the Spanish league season can resume in mid-June in closed stadiums without spectators, with fans not expected to be able to return to grounds until 2021.
Two goals by the dynamic Lionel Messi helped La Liga leaders Barcelona maintain their flying start to the season with a 5-1 destruction of Athletic Bilbao.
Another win would confirm that Barca are heading in the right direction after pushing the reset button following the loss of Lionel Messi in the close season due to their financial problems.
Striker Aduriz opened the scoring in the sixth minute at the San Mames with a trademark header before midfielder Garcia, who joined from Atletico Madrid last month, nodded in a second in the 24th minute.
With no fans allowed into venues and Real playing their home games at the 6,000-capacity Alfredo Di Stefano stadium while the Santiago Bernabeu is being refurbished, it will be a title race unlike any other.
Images from action in the Spanish Super Cup and English Premier League
According to widespread Spanish media reports, Netherlands coach and former Barca defender Ronald Koeman is set to be named as Setien's successor.
Liverpool frustrated by 10-man Arsenal in League Cup semi stalemate
Real Madrid were crowned Spanish Super Cup champions after goals from Luka Modric and Karim Benzema earned them a 2-0 win over Athletic Bilbao in Saudi Arabia on Sunday.
Manchester United and Liverpool, English football's two most decorated clubs, were drawn together in the last 16 of the Europa League on Friday.
Images from Saturday's action in La Liga.
Spain are still favourites to finish top of Group E above Sweden, Poland and Slovakia but, after struggling to break down conservative sides such as Georgia and Greece in March, they know coming first will not be a procession.
Barcelona pulled off a stirring comeback to overturn a two-goal deficit and reach the Copa del Rey final, beating Sevilla 3-0 after extra-time in Wednesday's semi-final second leg, to go through 3-2 on aggregate.
Football action from across Europe in matches played on Saturday
Premier League-based trio Diego Costa, Juan Mata and Santi Cazorla were among a high-profile list of absentees when Spain coach Vicente Del Bosque named his provisional 25-man squad for Euro 2016 on Tuesday. Costa injured his hamstring against Liverpool in Chelsea's penultimate game of the season. Atletico Madrid striker Fernando Torres was also absent from the squad despite his improved form towards the end of the season, as were Arsenal midfielder Cazorla and Valencia forward Paco Alcacer, Spain's top scorer in their qualifying campaign.
Athletic Bilbao claimed their first silverware in more than three decades when they wrapped up a 5-1 aggregate win over 10-man Barcelona to win the Spanish Super Cup on Monday and unleash ecstatic celebrations in the Basque city.
Images from the international friendly and Euro qualifying football matches played on Tuesday.
Arsenal right back Hector Bellerin will be in Spain's Euro 2016 squad, the country's football federation said on Tuesday. The 21-year-old Bellerin and the other 18 players named to face South Korea in a friendly in Wals-Siezenheim, Austria on Wednesday, have been guaranteed spots in the European Championship squad. Bellerin was included after Real Madrid right back Dani Carvajal sustained a leg muscle injury in Saturday's Champions League final victory over Atletico Madrid. The Real Madrid and Atletico players in the squad will be named later on Tuesday when Spain coach Vicente del Bosque announces his final list.
Real Madrid were made to toil by the 10 men of Athletic Bilbao but eventually won 3-1 on Tuesday thanks to two strikes from Karim Benzema to go level on points with La Liga leaders Real Sociedad.
Barcelona bounced back from their painful Clasico loss in style as they cruised to a 3-0 home LaLiga win over Villarreal with a brace from Robert Lewandowski on Thursday.
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