Djokovic did not play badly in the final but it took him 55 minutes before he registered his first game in what turned out to be a mauling.
Carlos Alcaraz came through a testing third round encounter against Nicolas Jarry.
The unseeded Ostapenko, 20, downed Romanian third seed Simona Halep 4-6, 6-4, 6-3 in the final, hitting a staggering 54 winners and taking her tournament tally to 299.
Paris crowd made themselves heard on day one of the French Open as they booed and jeered when Ukraine's Marta Kostyuk refused to shake hands
In the ongoing Monte Carlo Masters, Jannik Sinner clinched a hard-fought win as Casper Ruud crashed out.
Images from Day 1 of the 2024 Australian Open in Melbourne on Sunday.
Naomi Osaka has pulled out of the Wimbledon championship
Images from Day 11 of the 2021 French Open at Roland Garros in Paris on Wednesday.
Naomi Osaka is happy to be lost in her virtual world.
Federer decided to end his Roland Garros campaign on Sunday, a day after winning a gruelling third-round match against Dominik Koepfer.
Images from Day 5 of the 2021 French Open, in Paris, on Thursday.
The Serbian's 1-6, 6-3, 6-1 defeat also ended his dream of winning an Olympic singles gold medal, the only major honour missing from his long list of accolades.
Both in action in the French Open second round on Wednesday, could be considered the tournament's favourites.
'I have a lot of other goals, dreams that are in my mind and within my team and we'll certainly reset in the next couple of days ... enjoy some time together and then we go again. But really looking forward to the Olympics.'
Second seed Rafael Nadal said he would make no excuses after his shock loss to American Frances Tiafoe in the US Open fourth round Monday, despite a serious abdominal injury that derailed his run-up to the year's final major.
Images from the US Open women's semi-finals on Thursday.
Francesca Schiavone became the first Italian woman and the oldest first-time Grand Slam winner since 1969 when she won the French Open in 2010
Novak Djokovic beat Norway's Casper Ruud 7-5, 6-3 to collect a record-equalling sixth ATP Finals title on Sunday, earning the biggest paycheck ever in tennis - $4,740,300 - for completing the season-ending tournament unbeaten.
Sunday's final was an intense contest as nerves played their part, with 10 of the 22 games going against serve.
The French Open tennis tournament has been postponed until September 20-October 4 amid the coronavirus outbreak, organisers of the season's second Grand Slam said on Tuesday. It was initially scheduled to be played from May 24-June 7.
Novak Djokovic has suffered more than his fair share of heartache against Rafael Nadal at the French Open but Sunday's final offers him a chance to dethrone the claycourt king.
Serena Williams recovered from a set down to beat Australian Ashleigh Barty 3-6, 6-3, 6-4 and book a place in the third round.
The 20-year-old Korda, son of 1992 runner-up Petr, had enjoyed a dream run in his first Tour-level event on clay and was up against his idol -- the man he named his cat after.
Tsitsipas pulled out of the Wimbledon warm-up event in Halle, Germany, because of personal reasons
The 20-year-old Ostapenko was the first unseeded woman to lift the Suzanne Lenglen Cup since Britain's Margaret Scriven in 1933.
Krejcikova became the first player to win both the women's singles and doubles title in Paris since Mary Pierce completed the feat in 2000.
Images from Day 1 of the 2020 French Open, in Paris, on Sunday.
The German pair, who beat 16-time major champions Mike and Bob Bryan en route to the final, raced through the opening set with two early breaks.
Maria Sharapova knows the pitfalls of being a prodigy and after easing into the fourth round at Roland Garros the seasoned grand slam champion offered some sage advice to the new generation in women's tennis.
Monfils said all players were not similarly equipped to deal with the pressure of being a top athlete.
World number one Novak Djokovic said his win over Rafa Nadal in Friday's epic French Open semi-final was one of the top three matches he had played and he would remember it forever.
18-year-old Carlos Alcaraz entered the top 10 at the same age, on the same date and after a triumph in the same tournament as compatriot and 21-times major winner Rafael Nadal did in 2005.
Rafael Nadal is tied with Roger Federer as the player with the most men's singles majors and the Spaniard can now overtake his great rival who has skipped the Australian Open.
Medvedev's deep groundstrokes have been a major component of his clay-court progression. His baseline retrieving has been the foundation of his hard-court success, and he attributed his success on the clay this year to a string change at the start of the 2023 season.
Shapovalov pulls out of French Open.
US Open champion Carlos Alcaraz has become the youngest world number one since the ATP rankings began in 1973.
A round-up of Day 1 at the French Open.
Dominic Thiem will watch a treasured home movie of his recent win over Novak Djokovic at the season-ending ATP Tour Finals as he seeks inspiration to take down the defending champion Serb in the Australian Open decider.