A win by Venus would keep the 35-year-old on track for a first grand slam title since 2008 Wimbledon and a possible return to the US Open final where she first made the final in her debut in 1997. But a victory would end little sister Serena's quest for the rarest of tennis feats -- a calendar-year grand slam.
The Australian Open has seen many unheralded players punching above their weight. Rediff.com takes a look at a few such unseeded players who went the distance in the new millennium.
Images from Day 5 of the Australian Open in Melbourne on Friday.
Playing tennis professionally can be difficult physically, mentally and emotionally. But the tennis courts have often been the venue for for blossoming romance as love-struck couples decide it is game, set and match.
Serena Williams edged past Spain's Garbine Muguruza 2-6, 6-3, 6-2 to reach the quarters.
Wimbledon's genteel surrounds resembled Saturday night on a casualty ward as injuries saw seven players withdraw or retire and third seed Maria Sharapova stumble to a shock second-round defeat on Wednesday.
Maria Sharapova, Serena Williams and Andy Murray were the big names to win on Monday and advance to the quarter-final of the Wimbledon.
Top seed Agnieszka Radwanska's title defence at the Sydney International lasted just 92 minutes when she was dumped out of the second round by Bethanie Mattek-Sands on Tuesday.
China's Li Na will meet Serena Williams in the final of the WTA championships after beating Czech Petra Kvitova 6-4, 6-2 on Saturday, becoming the highest-ranked player ever from an Asian country.
Konta first British woman in US Open last 16 since 1991
Images from Wednesday's matches at Roland Garros
Second seed Garbine Muguruza, bidding to add the Wimbledon crown to her French Open title, was sensationally beaten in the second round on Thursday by Slovakian qualifier Jana Cepelova 6-3, 6-2 in the shock of the tournament so far.
Former FIFA official Jerome Champagne formally announced on Monday that he will stand against incumbent Sepp Blatter in next year's election for president of the world soccer body.
Defending champion Novak Djokovic moved confidently into the second round of Wimbledon with a 6-4, 6-4, 6-4 win over German Philipp Kohlschreiber on Monday.
Former World No 1 Ana Ivanovic was upset 7-5, 6-4 by 42nd-ranked Karolina Pliskova of the Czech Republic in the second round of the US Open on Thursday.
US Open champions Marin Cilic and Serena Williams kicked off their China Open campaigns with straight sets victories against battling underdogs on Monday, but Rafael Nadal suffered defeat in a rare doubles outing on his return from injury.