The result leaves Arsenal in fifth place on 15 points, two behind Leicester City and Chelsea, while Sheffield United moved into ninth on 12 points.
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
Five talking points from the Premier League weekend:
A summary of Saturday's matches in the English Premier League.
Leicester City won at Arsenal for the first time in 47 years on Sunday, with substitute Jamie Vardy's late close-range header enough to secure victory in the Premier League at The Emirates.
Arsenal squandered a two-goal lead as Watford hit back to draw 2-2 in new manager Quique Sanchez Flores's first game of his second stint in charge at Vicarage Road on Sunday.
IMAGES from the English Premier League matches played on Wednesday.
Mark Roberts, the national lead for football policing, told Sky he was concerned about some of the comments he had heard regarding the conditions for restarting the league, which was suspended in mid-March due to the COVID-19 pandemic.
IMAGES from the English Premier League matches played on Tuesday
IMAGES from the English Premier League matches played on Saturday
Veteran Drogba showed that he still has a lot of steam in him as he scored in Chelsea's win over Spurs, while Aguero continued to top the goal-scorers' list this season, finding the net for City. Images from the EPL matches played across England on Wednesday.
IMAGES from Saturday's English Premier League matches.
Crystal Palace's chefs will cook 900 meals a week for frontline healthcare workers and vulnerable families in south London during the COVID-19 pandemic, the Premier League club said on Monday. The food will be delivered to doctors and nurses in the National Health Service (NHS), elderly and vulnerable people forced to stay at home, impoverished families and the homeless.
Messi doesn't need to win a World Cup to prove his greatness, feels iconic former Argentine striker Hernan Crespo.
The following are talking points from the Premier League weekend:
Liverpool are on course to shatter the English Premier League's record points haul and the way Juergen Klopp's side are churning out wins it would now be a surprise if they failed to do so. With 19 wins and a draw they are averaging 2.90 points per game, putting them on course for 110 from 38 games which would also be a record for Europe's top five leagues.
Liverpool manager Juergen Klopp has urged the club's supporters to celebrate at home as the club prepare to lift the Premier League trophy following their clash with Chelsea on Wednesday. Klopp's Liverpool secured their first top-flight title in 30 years with seven games to spare and will be presented with the trophy on a special podium built on the Kop stand at Anfield.
Fulham's home game against Brighton & Hove Albion on Wednesday has also been pushed behind closed doors, while West Ham United too will host Crystal Palace without spectators on the same day.
Arsenal midfielder Jack Wilshere will be out of action for three months after undergoing ankle surgery, the Premier League club said on Thursday.
Raheem Sterling scored a second-half hat-trick as leaders Manchester City beat Watford 3-1 on Saturday while Liverpool kept the gap at one point by overcoming Burnley 4-2 on Sunday.
IMAGES from the English Premier League match played between Arsenal and Chelsea at Emirates Stadium in London on Sunday.
Manchester United kept up their chase for a Champions League qualification spot with Marcus Rashford and Anthony Martial on target in a 2-0 Premier League win over Crystal Palace, while Leicester secured a 2-0 home win over Sheffield United.
Images from the English Premier League matches played on Saturday.
Liverpool have the joint biggest lead in top-flight history at this stage of the campaign and no team has ever failed to win the title with an advantage of this size. Already there is talk of Liverpool going through the league entire season unbeaten -- matching the 'The Invincibles' of Arsenal in 2003/04 and Preston North End in 1888/89.
IMAGES from the English Premier League matches played on Wednesday.
The following are talking points from the weekend's Premier League action:
The former Chelsea goalkeeper had to wait for 11 games to reach the landmark and produced an inspired performance that included a second-half penalty save from Watford striker Troy Deeney to help Arsenal seal the win.
Eight wins and a draw in their last nine games had seen Leicester emerge as the closest pursuers of runaway leaders Liverpool but they went down 3-1 at the Etihad despite taking an early lead through Jamie Vardy. Images from the English Premier League matches played on Saturday.
IMAGES from the English Premier League matches played on Wednesday
'This team is really good and we have invested a lot in it. Now we have to work with that'
The 2019-20 English Premier League season must be scrapped and declared null and void if it cannot be restarted due to the coronavirus pandemic, Manchester United defender Luke Shaw said. The Premier League confirmed last week that the season, originally suspended until April 30, will not resume at the beginning of May and will only return when the situation stabilises.
Images from EPL matches played on Tuesday
Images from the English Premier League matches played on Saturday
The 13-year-old Burnley fan who made a racial slur against Spurs' Son Heung-Min will be made to work in conjunction with Kick It Out and Burnley FC in the Community programs.
IMAGES from the English Premier League matches played on Sunday
The United fans, who celebrated the victory at the end of the game with the manager and players, have not been the source of criticism of Solskjaer -- indeed the Norwegian has enjoyed strong backing from supporters who attend games at Old Trafford and those who travel away.
Shakespeare assumed a caretaker role in February after Claudio Ranieri, who led Leicester to a stunning Premier League title triumph in 2015-16, was dismissed with the club mired in relegation trouble.
Liverpool's bandwagon rolled on as they crushed Merseyside rivals Everton 5-2
Players have accepted that playing games in closed stadiums might be the only way to complete the English domestic league season, Bobby Barnes, deputy chief executive of the Professional Footballers' Association (PFA), has said. English soccer has been suspended until at least April 30 due to the coronavirus crisis, although the Football Association, Premier League and EFL have agreed to extend the season indefinitely.
Here are five talking points from the weekend's action: