The 20-year-old Canadian, who has not competed since she suffered a knee injury last October, said on Twitter she made the difficult decision because the COVID-19 outbreak has compromised her ability to reach her highest level of form.
The Swiss great is looking to win a 102nd tour-level trophy and move closer to Jimmy Connors' record of 109.
A look at the records of Garbine Muguruza and Sofia Kenin ahead of their Australian Open final on Saturday.
Nadal set to face Kyrgios clash in second round
Novak Djokovic wore down Lucas Pouille after an even first set, dispatching the Frenchman 7-6(2), 6-1 in a Cincinnati Masters quarter-final in Ohio on Friday.
Naomi Osaka was beaten 6-0, 6-4 by Greek 23rd seed Maria Sakkari.
Murray was made to fight for two hours and 52 minute
Fashion statements from Roland Garros...
The French Open, traditionally held in May-June, was postponed earlier this year due to the COVID-19 pandemic and will now be held at Roland Garros from Sept. 27-Oct. 11.
Sofia Kenin lifted her first Grand Slam trophy in Melbourne at the start of the year and then added a WTA title in Lyon, days before the circuit came to a halt due to the novel coronavirus pandemic.
"(Novak) has said that he views this as a private matter for him. We would love to see Novak here, he knows that he'll have to be vaccinated to play here."
Kei Nishikori's hopes of playing at the US Open have faded further after the Japanese former world number four revealed he had tested positive for COVID-19 for a second time.
Serena Williams, who had come into the first Grand Slam since in Auckland claiming her first title since becoming a mother, suffered an error-strewn 6-4, 6-7(2), 7-5 defeat by China's Wang Qiang in the third round at the Australian Open on Friday.
Djokovic will need to win in Tokyo and then the US Open later this year to achieve the feat that has so far only been accomplished by Steffi Graf in 1988.
Images from the third day at the US Open, the final Grand Slam tournament of the year, in New York, on Wednesday:
Images from Day 3 of the French Open matches played at Roland Garros on Tuesday
'I think it's (pressure) maybe because I haven't played in an Olympics before and for the first one to be here was a bit much.'
Osaka also reached the final of the Western & Southern Open, which was held at Flushing Meadows this year due to the COVID-19 pandemic, but had to withdraw against Azarenka due to an injury.
Maria Sharapova will return to tournament action at the Brisbane International next month
Images from Day 8 of the 2021 US Open in New York on Monday.
The French Open will be able to welcome only 1,000 people a day, including players, staff and organisers, down from the 5,000 spectators it had hoped for,
Eight-time Wimbledon champion Roger Federer, who turns 40 this year, takes on Frenchman Adrian Mannarino in round one.
'Anglo-Indians have played a significant role at the forefront, meeting every challenge to the security of the motherland.' A fascinating excerpt from Barry O'Brien's The Anglo-Indians: A Portrait of a Community.
A look at the actors, who have been a part of the franchise and are no more.
American Serena Williams has also said that the dropouts will not take the shine off a potential record-equalling 24th Grand Slam title for her.
Dowse said that the women's competition will see 10 former Grand Slam champions, including 23-time major winner Serena Williams, along with 81 of the top 100. In the men's event, seven of the world top ten are competing.
Osaka was fined $15,000 for skipping her news conference after her first round win and was warned of possible expulsion from Roland Garros
Greek tyro Stefanos Tsitsipas' dream run at the Rogers Cup continued on Friday as the teenager toppled defending champion Alexander Zverev 3-6, 7-6(11), 6-4 to reach the semi-finals in Toronto.
Here are eight women to watch during the US Open which starts on Monday.
Summary of sports events and persons who made news on Monday
Novak Djokovic will begin his Australian Open title defence against Frenchman Jeremy Chardy, while reigning women's champion Sofia Kenin meets wild card Maddison Inglis, following the draw for the year's first Grand Slam on Friday.
This year's Australian Open will be allowed to admit up to 30,000 fans a day, around 50% of usual capacity, amid the COVID-19 pandemic.
A look at the top women's contenders at the 2020 French Open.
IMAGES from the matches played during the Wimbledon Championships at the All England Lawn Tennis and Croquet Club, at Wimbledon in London on Thursday
Serena will not be in the US team for the Tokyo Olympics
Karolina Pliskova overcame a slow start before beating Garbie Muguruza 4-6, 6-2, 7-6 (6) in her opening match at the WTA Finals. In a contest between two former No. 1-ranked players, the third-seeded Pliskova struggled early adjusting to the nearly 5,000-feet altitude of Guadalajara, Mexico's second largest city on Wednesday.
Serena Williams, who has a history of blood clots and pulmonary embolisms, said she has concerns over travelling to New York and is living in a rented house instead of the official players' hotel as a precaution.
Images from Saturday's action at the Australian Open.
Three-time US Open champion Djokovic, who comes into the tournament having won his fifth Wimbledon title, is followed in the seedings by 2017 winner Rafael Nadal.
Austrian Thiem was 6-2, 3-6, 7-5, 5-7, 4-1 up when the men's match, which had already been halted on Friday because of bad weather, was stopped.
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