Gujarat Lions would be looking to get back to winning ways when they lock horns with Royal Challengers Bangalore.
The Men in Blue won the first T20I at Johannesburg by 28 runs and a victory on Wednesday will see them wrap up another series win on this tour.
Rohit's 115 off 126 balls was his first century on South African soil as came after failures in the earlier matches in the series - his total score was 40 before the 5th ODI on Tuesday.
With an unassailable 3-0 lead in hand, India need just one more win to claim their maiden ODI series triumph on South African soil.
Royal Challengers Bangalore will look to outgun title-contenders, Gujarat Lions in a must-win Indian Premier League clash.
Bowler Jaydev Unadkat in another player to watch out for as the three-match series in the shortest format kicks off in Johannesburg on Sunday
South Africa's success in Australia is often put down to their comfort on the hard local tracks, which can be similar to those at home, but they could face some unfamiliar conditions this year.
Earlier, on the back of Virat Kohli's 160 (not out), India reached a total of 303 for 6 in their 50 overs.
A buoyant India will look to cash in on South Africa's injury woes, compounded by the loss of captain Faf du Plessis, when the two sides meet in the second One-Day International in Centurion on Sunday.
Royal Challengers Bangalore will be looking to take the confidence from their Monday night's nerve-wracking one-run victory when they clash with Mumbai Indians.
590 cricketers -- including 370 Indian players and 220 overseas players -- will go under the hammer during the two-day mega auction in Bengaluru on February 12 and 13.
It will be a battle of survival for the two national captains as Virat Kohli's struggling Royal Challengers Bangalore square off against a fledgling Pune Supergiants led by Mahendra Singh Dhoni in an IPL encounter for the bottom-rung teams in Bengaluru on Saturday. With five defeats in seven games, RCB are currently placed at a lowly seventh spot in the table with four points while Pune are just a notch above in sixth spot courtesy their third win against Delhi Daredevils, on Thursday. It has been a tough journey for the two superstars of Indian cricket as their franchises have dished one disappointing performance after another. RCB with perhaps the most intimidating batting line-ups has had to taste defeat because of a pedestrian bowling attack that has failed to defend 180 plus scores in most of the matches.
Star batsman Virat Kohli's maiden T20 hundred went in vain as Gujarat Lions produced a clinical batting display to beat Royal Challengers Bangalore by six wickets in an IPL match in Rajkot on Sunday.
'I firmly believed that the wrist spinners can add lot of value as they are not dependant on the surface. It is about what you do in the air and you have varieties bowling leg-spinners as well as googlies'
India have never won an ODI series in South Africa, having lost 5-2 in 1992-93, 4-0 in 2006- 07, 3-2 in 2010-11 and 2-0 in 2013-14.
Desperate to get their campaigns back on track, the two bottom placed teams in the Indian Premier League -- Kings XI Punjab and Royal Challengers Bangalore -- lock horns in Mohali on Monday, aiming to keep their winning momentum going to stay afloat in the ninth edition of the T20 league.
Captain Virat Kohli and AB de Villiers smashed brisk half centuries to guide Royal Challengers Bangalore to a well-deserved 13-run victory over Rising Pune Supergiants in the Indian Premier League match, in Pune, on Friday.
IMAGES from the 3rd T20I played between India and South Africa in Newlands, Cape Town on Saturday
"This will probably be the biggest World Cup, so there will be great expectations and I know we will do very well for the people of the West Indies," he added.
Royal Challengers Bangalore will stand in the way of two-time former champions Kolkata Knight Riders' bid to make it to the play-offs in a mouthwatering Indian Premier League encounter.
Rajneesh Gupta profiles the cricketers playing the World Cup 2019.
Rajneesh Gupta presents all the fascinating career numbers of players in the World Cup.
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