Juventus closed on their 29th Italian title with a 1-0 win over AC Milan thanks to Arturo Vidal's second-half penalty on Sunday.
Italian side Napoli has moved into second place in their Champions League Group F on Wednesday with a 3-2 win over French side Marseille at Sao Paolo.
Coach Maurizio Sarri was sent off as Napoli wasted a chance to return to the top of Serie A when they were held 1-1 at home by AC Milan in a tense encounter.
Napoli squandered a two-goal halftime lead, then scored two late goals to beat nine-man AC Milan 4-2 in a stormy Serie A match which saw eight other players booked on Saturday.
Carlo Ancelotti's side held a two-goal lead at halftime thanks to strikes from Dries Mertens and Kostas Manolas, but Balotelli pulled one back as Brescia rallied after the break.
Hundreds of blue and white Napoli scarves were tied to railings outside the stadium, and flowers, childrens' pictures, church candles and even a bottle of wine were laid out along the pavement in a rapidly expanding, makeshift shrine.
Duvan Zapata scored a goal of sheer brute force and determination to set Napoli on the way to a 2-0 win over Sassuolo which moved them another step closer to second-placed AS Roma in Serie A on Monday.
Heavyweight trio Manchester City, Manchester United and Chelsea kept up their 100 per cent starts to the Premier League season this weekend.
News of all that's transpired on and off the football field
Lazio survived a storming Napoli fight back, including a missed penalty, as they won 4-2 on Sunday to finish third in Serie A and qualify for the Champions League playoff round after both teams finished with 10 men.
Napoli booked a clash with AS Roma in the Italian Cup semi-finals after a late instinctive Gonzalo Higuain backheel lifted Rafael Benitez's side to a 1-0 win over Lazio on Wednesday.
IMAGES from the Europa League matches played on Thursday
Lazio thumped Empoli 4-0, their eighth successive league win, to go second in Serie A on Sunday and Napoli ended their dismal run with a 3-0 win over Fiorentina despite being denied a clear goal.
Serge Gnabry scored twice as Bayern Munich beat Chelsea 3-0, while Antoine Griezmann's second-half equaliser handed Barcelona a vital away goal and earned them a 1-1 draw at Napoli in their Champions League last 16, first leg on Tuesday.
Later on Monday, Lukaku's brace helped Inter to a win over Napoli, taking them atop the standings on goal difference from Juventus.
Cristiano Ronaldo opened the scoring as Juventus beat visiting Bologna 2-1 on Saturday to move four points clear at the top of the Serie A table. Ronaldo struck from close range after 19 minutes, but Danilo levelled for the visitors soon afterwards.
Images from the Champions League matches played across Europe on Tuesday
Napoli kept their hopes of a first Serie A title since 1990 alive with an epic 4-2 win over 10-man Inter Milan after a Carlos Tevez hat-trick had put leaders Juventus six points clear with a 4-0 rout of Sassuolo on Sunday.
News of all that's transpired on and off the football field
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.
Alexandre Lacazette's free-kick sent Arsenal into the Europa League semi-finals with a comfortable 1-0 win away over Napoli, while Chelsea beat Slavia Prague 4-3 in a roller-coaster game, helped by a Pedro brace.
Following this stunning turn-around of fortunes for Barcelona, here is a flashback of some of the best come-from-behind wins recorded in Europe's premier club competition.
Juventus raced into a 2-0 halftime lead after Napoli goalkeeper Alex Meret was sent off in the 25th minute. The visitors then had Pjanic dismissed and Napoli's Jose Callejon pulled one back before Insigne let the Turin side off the hook.
It was a dramatic night at the Champions League as Barcelona's Anssumane Fati -- 17 years and 40 days old - became the youngest to net a goal in the competition. Last season's semi-finalists, Ajax were eliminated by Valencia while Napoli's coach Ancelotti was shown the door despite the team's progress. Here are Images from the Champions League matches played on Tuesday
Following Bayern Munich's brilliant 7-4 (on aggregate) win over FC Porto in the quarter-finals of the Champions League, here's a look at a few memorable come-from-behind victories in Europe's premier football competition.
A summary of Tuesday's Group stage matches in the UEFA Champions League.
A summary of the results of the football matches played across Europe on Sunday
News of all that's transpired on and off the football field
A summary of Tuesday night's matches in the UEFA champions League.