Millman, ranked 80 places above world number 14 Pouille, needed 73 minutes to clinch a 6-3, 6-4 victory and the best win of his career by ranking position.
A rampant Rafael Nadal turned on the style to beat old rival Novak Djokovic 7-6(4), 6-3 on Saturday and reach his first Italian Open final since 2014. The top-seeded Spaniard will face defending champion Alexander Zverev who overcame fourth seed Marin Cilic of Croatia 7-6(13), 7-5 in the other semi-final.
Karolina Pliskova reached the Australian Open quarter-finals for the first time on Monday and is keen to prove right those tipping her for Grand Slam success.
Andy Murray embarks on his first Grand Slam campaign as world number one with much stronger title credentials, even if he has lost five finals at Melbourne Park.
Murray had battled his way back from two sets down in the second round against France's Adrian Mannarino, but could not work another miracle against the 14th-ranked, 29-year-old Anderson, who swept the final tiebreak 7-0.
Japan's Naomi Osaka claimed her first career title with a commanding 6-3, 6-2 victory over Russian Daria Kasatkina in a battle of 20-year-olds at the BNP Paribas Open on Sunday.
Serena Williams powered into the fourth round of the Australian Open on Saturday with a 6-2, 6-1 demolition of Dayana Yastremska then consoled the Ukrainian teenager after leaving her in tears.
Now with Serena sidelined for the impending birth of her first child, the two-time grand slam winner is delivering on the promise that could see her become the new face of women's tennis.
Swiss teenager Belinda Bencic capped a brilliant run to the Rogers Cup title on Sunday.
Roger Federer suffered a shock 3-6, 6-3, 7-6(4) defeat to Australian wildcard Thanasi Kokkinakis on Saturday that will cost the Swiss his world number one ranking and leaves the Miami men's tournament wide open.
IMAGES from Day 2 of the US Open played at Flushing Meadows in New York on Tuesday.
Stefanos Tsitsipas pulled off one of the biggest wins of his short but remarkable career by beating Rafael Nadal 6-4 2-6 6-3 on Spanish soil on Saturday to book his place in the Madrid Open final against world number one Novak Djokovic.
Multiple grand slam champion Maria Sharapova withdrew from the Brisbane International on Tuesday after suffering an arm injury in practise less than two weeks before the Australian Open.
Competition in the tennis circuit has grown stronger, and thus, according to women's World No 6 Agnieszka Radwanska, maintaining a position in the top 10 list in the women's rankings is harder than breaking into it.
Here are some of the reactions to the Grand Slam - originally scheduled for June 29-July 12 - being cancelled for the first time in 75 years.
Images from Day 1 at the Australian Open.
The Australian Open will lose one of its giant killers when South Korean Chung Hyeon meets American Tennys Sandgren in an unlikely quarter-final showdown at the Rod Laver Arena on Wednesday.
The sixth seed burnt the midnight oil in her all-Czech fourth round grudge match against Barbara Strycova, finally clinching a 6-7, 6-3, 6-2 victory at 1.35 a.m. local time on Tuesday morning.
Serena Williams clinched the year-end World No 1 ranking for the fourth time without hitting a ball on Friday after Maria Sharapova, the only woman with any chance of overtaking her, was eliminated from the WTA Finals.
Germany's Angelique Kerber, who will try to prevent Serena Williams winning an eighth Wimbledon title on Saturday, never went away but she too is making a comeback of sorts.
Spain's Garbine Muguruza insists she is enjoying herself at the French Open even if she doesn't look it, but don't expect her to smile too much until she gets her hands on the Suzanne Lenglen trophy for the second time in three years.
Summary of sports events and persons who made news on Tuesday
The top-seeded Serb, who had not dropped a set in four matches since the round of 16 at the Australian Open in January, looked out-of-sorts throughout the 98-minute contest.
The US Open women's semi-finals scheduled for Thursday evening have been postponed due to the threat of rain.
Tennis already sets the bar with equal prize money paid to women and men at Grand Slam tournaments
Top seed Dominic Thiem was knocked out the Rio Open in the first round on Tuesday, going down 6-3, 6-3 to Laslo Djere.
Fourth seed Angelique Kerber's bid for consecutive Grand Slam titles ended when 29th seed Dominika Cibulkova defeated the German 3-6, 6-3, 6-3 in the US Open third round on Saturday.
Serena Williams is intent on defending her Olympic titles in Rio and finds it sad that several athletes will miss out on an 'amazing' experience because of worries about the Zika virus.
Simona Halep and Stan Wawrinka beat the heat with straight-sets wins to reach the third round of a sweltering US Open on Thursday while American hope Jack Sock wilted under the punishing conditions, collapsing on court.
Halep's near-flawless display at the All England Club marked a spectacular return to form after her world ranking dropped from first to seventh between mid-January and July.
Wawrinka splits with long-time coach Norman
Serena Williams brushed off some serving troubles before cruising to a 6-4, 6-3 win over Elina Svitolina on Saturday and will meet Simona Halep in the Western & Southern Open final.
Images from the second day at the US Open, the final Grand Slam tournament of the year.
World No 1 Novak Djokovic, second seed Andy Murray and three-time champion Rafael Nadal were all cheered into the quarter-finals of the Rogers Cup on Thursday.
"Think of it from a players' perspective. Some are hoping to reach the second week of a major but some don't even make it to the first week of the event. That's tough to take.
Images from Day 4 of the Australian Open in Melbourne on Thursday
Summary of sports events and persons who made news on Monday
The 20-year-old, free of a shoulder injury that forced her out of qualifying for last week's Hobart tournament, won her first match at the Australian Open at her fourth attempt with a 6-4, 7-5 victory over Germany's Annika Beck.
The Canadian's win sets up a semi-final clash with Del Potro on Saturday that will pit power against power.
Williams said the number 24 is becoming an obsession for the media who talk of little else
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