This is Sindhu's third consecutive first round loss.
Rising Indian shuttler Malvika Bansod continued her impressive form this year, pulling off a stunning upset against world No. 23 Sung Shuo Yun of Chinese Taipei to advance to the women's singles pre-quarterfinals of the Arctic Open Super 500 tournament on Tuesday.
Double Olympic medallist PV Sindhu sailed into the pre-quarterfinals but Lakshya Sen made an opening-round exit from the Kumamoto Masters Japan Super 500 tournament in Kumamoto, Japan on Wednesday.
Sindhu made short work of fifth seed Michelle Li of Canada 21-10, 21-19 in 36 minutes
Sindhu had won a gold in the mixed team event at the CWG in 2018, but a medal in singles has eluded her since her Games debut.
The Indian men's team, led by Srikanth, had beaten powerhouse and 14-time champions Indonesia in the final to win the country's maiden Thomas Cup title on Sunday.
In one of the biggest upsets for the India, medal hope Saina Nehwal crashed out of the Rio Games after suffering an straight-game loss upset against lower-ranked Maria Ulitina of Ukraine in her second Group G match at the Rio Olympics on Sunday.
Indian shuttlers Saina Nehwal, Kidambi Srikanth and Sameer Verma also advanced to the second round of the $550,000 tournament at the Barclaycard Arena.
All eyes will be on Indian ace Saina Nehwal when she returns to the court after an injury lay-off at the All England Championship, hoping to better last year's runner-up finish at the prestigious event which begins with the qualifiers in Birmingham.
Indian ace shuttlers Kidambi Srikanth and Parupalli Kashyap advanced to the pre-quarterfinals after notching up contrasting victories in the men's singles competition of the $ 120,000 German Grand Prix Gold in Mulheim an der Ruhr.
Indian shuttler HS Prannoy stunned reigning Olympic champion Lin Dan of China while Saina Nehwal and Parupalli Kashyap also crossed the opening hurdle to enter the second round of the USD 275,000 French Open Super Series.
Indian shuttlers continued their impressive show with top stars P V Sindhu, Saina Nehwal and Kidambi Srikanth progressing to the semifinals of their respective events in the 21st Commonwealth Games' badminton competition, in Gold Coast, on Friday.
Ace Indian shuttler Parupalli Kashyap suffered a major blow to his Olympic qualification hopes when he retired hurt midway through the German Open pre-quarterfinals at Mulheim an der Ruhr on Thursday.
Adapting to the conditions in Rio and changing on-court strategy in match situation will be the key to success, according to ace Indian shuttler P V Sindhu, who is aiming to add an Olympic medal to her two World Championship bronze medals.
Memories of a path-breaking gold medal at the 2010 Commonwealth Games are still fresh in her mind as Saina Nehwal embarks on a quest to regain the title at the Gold Coast Games starting next week.
Four years after a bronze at London Games made her the toast of the nation, Saina Nehwal will once again carry a billion hopes when she along with the other six shuttlers, including doubles exponent Jwala Gutta, begin their campaign at the Rio Olympics, in Rio de Janeiro, on Thursday.
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