Five-time winners Sevilla made light work of AS Roma when first half goals from Sergio Reguilon and Youssef En-Nesyri gave them a 2-0 win over AS Roma and sent them into the Europa League quarter-finals on Thursday.
Here are five talking points from the weekend's action:
Real Madrid's Gareth Bale has the qualities to fill the void left by his fellow forward Cristiano Ronaldo's move to Juventus, the Spanish side's new manager Julen Lopetegui has said.
A round-up of the action in the English Premier League on Monday.
Diego Costa gave Europa League holders Atletico a dream start against Champions League winners Real by firing them ahead after 49 seconds, knocking down a long pass and smashing the ball into the net from a tight angle.
New Everton boss Sean Dyche's reign began with a shock 1-0 victory over English Premier League leaders Arsenal.
News of all that's transpired on and off the football field
Real Madrid's interim coach Santiago Solari says the squad are hurting but determined to turn around their dismal start to the season.
Images from the English Premier League matches on Saturday.
Champions League holders Real Madrid will have to work around a string of injuries to key players in a tough match against CSKA Moscow, manager Julen Lopetegui said on Monday.
Spain coach Fernando Hierro said he had no regrets at taking the job two days before the World Cup despite his side's second-round exit at the hands of hosts Russia on Sunday.
He also had generous words for opposite number Carlos Queiroz, a master tactician who has made Iran an extremely hard nut to crack.
Second-placed Sevilla were held to a 1-1 draw by Barcelona, while Juventus registered a routine 2-0 win over struggling Cagliari.
Jose Mourinho dismissed speculation linking him with a return to Real Madrid, on Monday, saying he wants to stay on as Manchester United manager beyond his current contract.
Brazilian Malcom, who started in place of Lionel Messi, curled home in the 58th minute to pull Barcelona level after Lucas Vazquez had fired Real Madrid ahead early on.
Julen Lopetegui's side were awarded a penalty early in the game after a VAR review determined forward Nolito had been fouled by Valladolid's Javi Moyano as he shaped to shoot, even though his team mates had barely appealed for a foul.
A former midfielder for Sporting Gijon, Real Madrid and Barcelona, Luis Enrique won two Liga titles, one Champions League and three King's Cups as Barca coach between 2014 and 2017.
Real Madrid have signed Spain right-back Alvaro Odriozola from Real Sociedad on a contract until 2024, the European champions said on Thursday.
'It was surprising and I think that even though there were motives and reasons behind the decision, the players had no say in it and it was not the right time'
A round-up of Wednesday's action in the UEFA Champions League.
Santiago Solari got off to the perfect start as Real Madrid's interim coach when his side thrashed Melilla 4-0 in the Copa del Rey on Wednesday.
IMAGES from the English Premier League matches played on Saturday.
New coach Julen Lopetegui has been tasked with rebuilding the side following the Portugal forward's departure and the early signs are good, with Real already looking more of a unit than a collection of individuals.
Spain's new coach Luis Enrique said on Thursday that his tenure in charge of the 2010 world champions would be all about 'evolution, not revolution' but the former Barcelona manager also promised plenty of surprises in his first squad.
News of all that's transpired on and off the football field
A draw in Kaliningrad would guarantee the 2010 winners safe passage into the last 16 but to be assured of winning the group they need to win a scoring contest with Portugal, who play Iran at the same time.
Fernando Hierro now in charge of the team, Spain's next game is against Group B leaders Iran on Wednesday.
Spain's strong show of unity after the sacking of coach Julen Lopetegui was almost enough to secure victory in their World Cup opener against Portugal on Friday, but Cristiano Ronaldo's late goal took some gloss off a superb performance.
Portugal's Cristiano Ronaldo curled in a sizzling late free kick to strike the first hat-trick of the 2018 World Cup and grab his side a point in a thrilling 3-3 draw with Spain on Friday as the Group B blockbuster lived up to the hype.
Sporting Director of Spain's Football Federation (RFEF) Fernando Hierro has been named the national team's new coach for the duration of the World Cup in Russia, the Federation said in a tweet on Wednesday.
World Cup hopefuls France salvaged a late 1-1 draw against the United States in their final friendly before the tournament, while fellow title favourites Spain also needed a late oal as they edged past Tunisia 1-0 on Saturday. Elsewhere, there were wins for finalists Serbia, Denmark, Morocco and Australia, while Sweden were held to a goalless draw by Peru.
Centre-back Pique, who voted in the referendum and has criticised police violence against voters which resulted in hundreds of injuries, has long been targeted by Spain fans but Monday's barrage of insults was particularly severe.
Cristiano Ronaldo says he decided to quit Real Madrid this summer because the Spanish club's president, Florentino Perez, only ever saw him as a means of making money.
Real are third in the league standings with 54 points after 28 games, two behind second-placed Atletico Madrid who visit Athletic Bilbao later on Saturday and nine points behind leaders Barcelona who play at Real Betis on Sunday.
Real Madrid have started the season flying with three wins from three games.
A second half double from Karim Benzema helped Real Madrid to a 4-1 victory at Girona on Sunday and maintain their perfect La Liga start in the post-Cristiano Ronaldo era.
While that may not differ too much from the scenario in many group stage matches pairing the big beasts of the game against those nations who occupy lower rungs of the FIFA rankings, the X-factor in Kazan could be Carlos Queiroz.
The Manchester United keeper let a tame shot from Cristiano Ronaldo through his arms for Portugal's second goal on Friday and has been criticised in Spain for his badly positioned defensive wall when Ronaldo struck the late equaliser.
"We are not going to deviate one iota from our footballing concepts," the distinguished former Spain defender Hierro said.
New Spain coach Fernando Hierro plans to carry on Julen Lopetegui's good work as he prepares to lead his country into their World Cup opener against Portugal on Friday.