India all-rounder Axar Patel has been ruled out of the first Test against England with a knee injury, the Board of Control for Cricket in India said on Friday.
The 27-year-old complained of pain in his left knee during a training session on Thursday.
"He is being monitored by the BCCI medical team and while his detailed reports are awaited, he will not be available for selection for the opening match," the BCCI said in a statement.
Axar was picked as a replacement for star all-rounder Ravindra Jadeja, who is recovering from an injury and was in line to make his Test debut.
Spinners Shahbaz Nadeem and Rahul Chahar have been added to the squad ahead of the opening Test, which begins on Friday in Chennai.