Arsenal's title hopes suffer a blow with a home defeat to Bournemouth, while Liverpool strengthens their Champions League aspirations with a win over Fulham. Brentford and Everton draw in a battle of top-five contenders.
Matheus Cunha struck just before half-time to earn Manchester United a 1-0 victory at luckless Chelsea on Saturday, taking them a big step closer to Champions League football next season.
Arsenal's Premier League lead is cut to four points after a 1-1 draw against Brentford, with goals from Noni Madueke and Keane Lewis-Potter.
Manchester City blew a two-goal lead to draw 2-2 at Tottenham Hotspur on Sunday as a moment of magic by home forward Dominic Solanke handed Arsenal a huge Premier League title boost.
Arsenal's Premier League title prospects were enhanced without them even kicking a ball on Wednesday as their closest challengers Manchester City and Aston Villa both dropped points.
A summary of Saturday's action in the Premier League.
It took 10 Premier League games for the first cracks to appear in Manchester City's facade last season, but Pep Guardiola got a much earlier reminder of his side's fall from grace on Saturday in another defeat to Tottenham Hotspur.
Arsenal's Calafiori secures 1-0 win at Manchester United; Crystal Palace hold Chelsea to 0-0 draw.
Two goals from Wayne Rooney put Manchester United back on top of the Premier League for the first time in five months when they beat West Bromwich Albion 2-0 at Old Trafford on Sunday and Manchester City went down to a 1-0 defeat at Swansea City.
Goals from Curtis Davies and Robert Koren earned HullCity a place in the FA Cup quarter-finals with a 2-1 replay win at home to Brighton and Hove Albion on Monday.