Brighton kept a disciplined formation, frustrating Liverpool and as the second half wore on the home side began to lose their fluency.
Cristiano Ronaldo scored twice as Real Madrid came from behind to beat Paris St Germain 3-1, while Sadio Mane grabbed a hat-trick as Liverpool demolished Porto 5-0 away in the Champions League round-of-16 on Wednesday.
Only two teams -- Chelsea in 2005-06 and Manchester City last season -- have had more points after 18 Premier League games in a season than Liverpool's 48.
IMAGES from the Euro 2020 qualifiers played on Thursday
Veterans Arjen Robben (21) and Wesley Sneijder (34) laid the groundwork for a Dutch victory in coach Dick Advocaat's first game in charge.
It promises to be a tense and thrilling finale to the season but Liverpool, who have frittered away a seven-point lead, will need to regain their momentum quickly if they are to push for their first league title since 1990.
IMAGES from the English Premier League matches played on Sunday.
Liverpool manager Juergen Klopp wants his players to be "angry" and guard against complacency when they entertain promoted HullCity on Saturday.
Images from English Premier League matches played on Sunday.
Daniel Sturridge has said manager Juergen Klopp has put the Liverpool squad through the "most intense" pre-season of his career with the England striker pushing himself to the limit in a bid to avoid another injury-disrupted campaign.
The 32-year-old, who captained the Dutch to third place at the 2014 World Cup in Brazil, has been overlooked by coach Danny Blind, who is not convinced about his form with Fenerbahce.
Roberto Firmino struck a stoppage-time winner as Liverpool beat Paris St Germain 3-2 at Anfield on Tuesday after Kylian Mbappe looked to have secured a point for the French side in a compelling Champions League Group C clash.
A round-up of Thursday night's matches from the Euro 2020 qualifiers.
Unbeaten Liverpool have 45 points from 17 games with champions Manchester City, who beat Everton 3-1 on Saturday, a point behind.
Liverpool belatedly kick-started their year and damaged Tottenham Hotspur's slender Premier League title hopes as Sadio Mane struck both goals in a 2-0 victory at Anfield.
Liverpool continued their perfect start to the season to stay top of the Premier League after a goal in each half gave them a 2-1 victory over Tottenham Hotspur at Wembley on Saturday.
Juergen Klopp returns to the scene of one his Liverpool side's most controversial victories of last season this Saturday with the man who fashioned it lining up against him.
Liverpool were on the end of the biggest sensation of the English Premier League season when bottom club Swansea City repelled a dramatic comeback from Juergen Klopp's title chasers to earn their first-ever league win at Anfield.
'So, the Champions League final will be played between two teams who just don't know when they are beaten,' says Suhit K Sen.
Liverpool's livewire Sadio Mane scored one goal and played a crucial part in the other as they reclaimed the Premier League's top spot with a scrappy 2-1 win at second bottom Fulham on Sunday.
Newcastle United have signed Serbian forward Aleksandar Mitrovic from Belgian side Anderlecht, subject to a work permit, the Premier League club announced on Tuesday.
Liverpool scored three goals in 12 dramatic first-half minutes, two of them from Emre Can, on their way to a hugely entertaining 4-2 win over Hoffenheim which took them back to the Champions League group stage after a two-season absence on Wednesday.
Liverpool took over at the top of the Premier League table despite being held to a 0-0 draw against Manchester United in a scrappy match on Sunday.
Images from the English Premier League matches played on Saturday
A summary of Tuesday's Group stage matches in the UEFA Champions League.
One of the most eagerly-awaited clashes of the Premier League season turned into a major letdown as Liverpool and Manchester United nullified each other in a largely undistinguished goalless draw at Anfield on Monday.
Manchester City made sure of third place in the Premier League when they romped to a 5-0 win at Watford on Sunday to ensure a Champions League berth for next season.
The Netherlands failed to reach the European Championship for the first time since 1984 as they lost 3-2 at home to the 10-man Czech Republic in their final qualifier on Tuesday to miss out on Euro 2016.
Brazil ended their home World Cup to a cacophony of boos on Saturday as the defensive errors that crushed their bid for a sixth title resurfaced in a shoddy 3-0 loss to the Netherlands in the third-place playoff match.
Mario Mandzukic and Nikola Kalinic grabbed hat-tricks as Croatia achieved a record win as an independent nation by demolishing San Marino 10-0 in their final Euro 2016 warm-up match in Rijeka.
IMAGES from the English Premier League match played on Saturday
Images from the English Premier League matches played on Saturday
Arsenal eased past second-tier Reading 2-0 with Alex Oxlade-Chamberlain scoring twice, while Newcastle United romped to a 6-0 win over 10-man Preston North End and Hull City won 2-1 at Bristol City.
France striker Olivier Giroud ended a run of 10 international games without a goal by netting a stunning winner as the world champions claimed a deserved 2-1 victory over the Netherlands in their Nations League clash on Sunday.
Aston Villa beat Crystal Palace 1-0 to win a Premier League match for the first time since August while a late goal from Paul Dummett earned a 3-3 draw for Newcastle United against Manchester United on Tuesday.
A fortunate 85th-minute goal from Brazilian Willian earned Premier League champions Chelsea a 1-1 draw at Liverpool on Saturday after Mohamed Salah's 15th goal of the season looked to have given the hosts the three points.
Injuries have blighted Liverpool's start but Adam Lallana is back in full training after damaging his thigh pre-season and is expected to feature while another injury concern, Sadio Mane, also trained on Wednesday after tweaking a hamstring on international duty with Senegal.
Manchester United teenager Marcus Rashford wrote another chapter in his fairytale introduction to top-flight football, scoring a brilliant goal to secure a 1-0 win in his first derby match against Manchester City on Sunday.
FIFA's Task Force for Women's Football has called for a target of 30 percent women's participation in the governing body's leading structures and top jobs, FIFA said on Thursday.
West Ham United capitalised on two mistakes from Arsenal's new goalkeeper Petr Cech to claim a surprise 2-0 victory at the Emirates and bring the Gunners' early Premier League optimism down to earth with a bump on Sunday.
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