With no fans allowed into venues and Real playing their home games at the 6,000-capacity Alfredo Di Stefano stadium while the Santiago Bernabeu is being refurbished, it will be a title race unlike any other.
Real Madrid rested Cristiano Ronaldo and suffered a fifth Liga defeat of the season as Espanyol's Gerard Moreno struck late for a 1-0 win over the Spanish and European champions.
Images from the UEFA Champions League matches played on Tuesday night.
Barcelona travel to newly-promoted Osasuna without their first choice front line.
Cristiano Ronaldo showed nerves of steel to score an injury-time penalty and send holders Real Madrid into the semi-finals of the Champions League in extraordinary circumstances as they lost 3-1 to Juventus on Wednesday but won a thrilling tie 4-3 on aggregate.
Zinedine Zidane's Real side demonstrated their new-found grit to re-take the lead
After more goals came from set-pieces in this World Cup's group stage than any other, dead-ball strategy has continued to have a huge impact in the knockout phase, with five of the 11 goals scored in the quarter-finals coming from free kicks or corners.
Lionel Messi celebrated his sixth Ballon D'Or award with a brilliant hat-trick as Barcelona moved back top of La Liga with an emphatic 5-2 victory over Real Mallorca.
Real Madrid suffered an almighty fright before a Cristiano Ronaldo hat-trick hauled them back from 2-1 down and gave them a 4-2 win over rank outsiders Kashima Antlers in the Club World Cup final on Sunday.
Striker Mariano's header was glanced onto the crossbar by Sociedad's Andoni Gorosabel while the loose ball fell to Marco Asensio, whose shot was deflected wide for a corner from which Raphael Varane header hit the top of the bar.
Cristiano Ronaldo scored twice as Real Madrid beat Athletic Bilbao 4-2 in a thrilling match at the Bernabeu to move within a point of leaders Barcelona in La Liga on Saturday.
Teenager Curtis Jones grabbed a 58th-minute winner as an injury-hit Liverpool qualified for the knockout stage of the Champions League with a 1-0 win over Ajax Amsterdam at Anfield on Tuesday.
France's chance against Argentina in the World Cup last 16 might be that Lionel Messi does not benefit from the same support with the national team than at Barcelona, his club team mate Samuel Umtiti said on Thursday.
Real Madrid forwards Marco Asensio and Karim Benzema struck to give their side a 2-0 win at home to Eibar in La Liga
The Belgian forward came off the bench to make his Real debut in Saturday's 3-2 win over Levante, having had his start to life at the club hit by a thigh injury the day before the La Liga season began.
Both sides had shots cleared off the line but Real were left feeling more disappointed after winning the tactical battle but failing to take their chances.
Spanish media has reported that Solari, 42, is to be relieved of his duties
With the teams having played their second matches in the league stage in Euro 2020, at the conclusion of the Spain-Poland match in Group E on Saturday, here's a look at the best goals from those matches.
The victory saw Spain finish top of League A4 with 11 points after six games, joining France in the final four tournament, which will take place in October 2021.
Juventus coach Massimiliano Allegri believes Cristiano Ronaldo deserves to win the Ballon D'Or, following media reports that the forward has not been short-listed for the award's final three for the first time since 2010.
Karim Benzema scored twice after the interval with a penalty and a header from a corner to give Santiago Solari's side a 3-1 lead, after Raphael Varane struck in the 34th minute to cancel out Anuar Tuhami's goal for Valladolid five minutes earlier.
Brazilian Malcom, who started in place of Lionel Messi, curled home in the 58th minute to pull Barcelona level after Lucas Vazquez had fired Real Madrid ahead early on.
Rami believes he still has a vital role to play although he is unlikely to line up against Uruguay in Friday's quarter-final in Nizhny Novgorod.
Kylian Mbappe believes Les Bleus have what it takes to win the title in Russia if they all stick together.
Champions Real Madrid were beaten at home by promoted Cadiz, while Barcelona fell to their first defeat in La Liga under new coach Ronald Koeman as they lost to Getafe.
France coach Didier Deschamps confirmed his final Euro 2016 squad on Tuesday, including defenders Adil Rami and Samuel Umtiti in place of the injured Raphael Varane and Jeremy Mathieu. Liverpool centre back Mamadou Sakho was not included even though his 30-day provisional suspension for failing a drugs test expired last weekend. Hosts France geared up for the finals with a 3-2 victory over Cameroon in Nantes on Monday. They take on Scotland in Metz on Saturday.
Manchester Utd's Fred receives racist abuse after defeat by Liverpool.
Cristiano Ronaldo celebrated his recent Ballon d'Or award by scoring twice for the first time in a La Liga game this season as champions Real Madrid swept to a stunning 5-0 win over Sevilla on Saturday to go five points behind leaders Barcelona.
Real Madrid are determined to create an intimidating atmosphere for visitors VfL Wolfsburg as they try to overturn a two-goal deficit in Tuesday's Champions League quarter-final second leg at the Santiago Bernabeu stadium.
A summary of Wednesday night's action in the UEFA Champions League.
Real Madrid forward Vinicius Jr. score twice as his side punished a sloppy Liverpool to win 3-1, while Manchester City beat Borussia Dortmund 2-1 in Tuesday's Champions League quarter-final first leg.
Brazil inflicted France's first defeat since the World Cup when a perfectly executed second-half performance earned them a 3-1 win in a friendly game at the Stade de France on Thursday.
Real are third in the league standings with 54 points after 28 games, two behind second-placed Atletico Madrid who visit Athletic Bilbao later on Saturday and nine points behind leaders Barcelona who play at Real Betis on Sunday.
Uttar Pradesh was alerted about the possibility of terrorist attacks in public places, Minister of State for Home Sri Prakash Jaiswal said on Sunday.
Images from Tuesday's action in the UEFA Champions League.
Luka Modric pulled one back for Zinedine Zidane's shellshocked side with a brilliant strike from distance early in the second half before substitute Vinicius Jr reduced the deficit to one goal.
Toni Kroos struck with a fierce long-range shot a minute from time to give Germany a 1-0 victory over Spain in a friendly between two injury-depleted European heavyweights in Vigo on Tuesday.
Real have underperformed on the domestic stage, trailing Barcelona by 15 points and knocked out of the King's Cup by Leganes, and many predicted an early elimination from Europe when they drew the runaway Ligue 1 leaders in the last 16.