Index heavyweight RIL surged 3% to end above Rs 1,000 mark while IT majors were also the top gainers.
Natco Pharma, Wockhardt and Marksans have rallied between 50 and 70 per cent in the year till date.
The benchmark Nifty rallied 1,000 points or 17% from 7,000 in 78 trading sessions since May 12, till date to surpass the 8,000 mark.
Special 301 Report expresses concern over weak IPR laws, to conduct reviews.
Sensex ends 134.91 pts down at 28,709.87; Nifty falls 44.70 pts at 8,712.05.
Sensex rises, Nifty ends at record high; RIL shares rally.
The Nikkei share average rose 2.6% to close at 15,195.77 points, more than recouping Tuesday's losses.
Ajit Mishra, vice president, Research, Religare Broking, answers your queries:
Benchmark share indices ended lower for the third straight session as investors turned cautious amid tensions in Iraq even as consumer durables shares stole the limelight tracking rally in gold prices.
'Pay-for-delay' settlements between drug patent-holders and generics manufacturers to delay the launch of cheaper generic medicine are increasingly being scrutinised by antitrust regulators
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