Alex Ferguson famously described the Premier League title run-in as 'squeaky-bum time' and leaders Leicester City and second-placed Tottenham Hotspur look best-placed to handle the pressure.
United beat Leicester City at Old Trafford in the opening game of the season but Spurs present a very different quality of opponent.
Tottenham Hotspur's exhilarating Premier League title surge came to a shuddering halt as they lost 1-0 at West Ham United on Friday to leave Chelsea needing six points from four games to be crowned champions.
IMAGES from the EPL matches played on Wednesday
The London club dominated the first half but fell behind to a superb goal from their former winger Aaron Lennon before young midfielder Dele Alli furthered his case for a place in England's midfield with a classy equaliser just before the break.
Tottenham Hotspur have the chance to exert psychological pressure on Premier League leaders Chelsea when they open the weekend programme at home to Watford on Saturday.
West Ham United's hopes of avoiding relegation suffered a cruel blow as an own goal by midfielder Tomas Soucek and Harry Kane's first goal since December condemned them to a 2-0 defeat at Tottenham Hotspur on Tuesday.
Tottenham Hotspur spent the cash earned from Gareth Bale's sale on a plethora of internationals but the key to the remarkable 5-3 win over Chelsea on Thursday, and their best player this season, had been there all along.
News of all that's transpired on and off the football field
Liverpool's Raheem Sterling netted a sharply-taken double in a 3-1 win over Bournemouth on Wednesday to set up a League Cup semi-final with Chelsea.
"Harry Kane, he's one of our own," Tottenham Hotspur supporters sing in praise of the 21 year-old striker from Chingford, the London suburb where David Beckham learnt his football.
Cristiano Ronaldo and Lionel Messi will again be duelling for the title of world's best footballer after their names once again headed the shortlist on Thursday for The Best FIFA Men's Player.
Real Madrid coach Zinedine Zidane is leaving the European champions after two years in charge.
Premier League title race looks poised to be one of the most thrilling in years.
IMAGES from the EPL matches played on Tuesday
Arsenal have only lost six times to Tottenham Hotspur in 43 matches since Arsene Wenger became their manager nearly 18 years ago, but the Frenchman is taking nothing for granted before the first north London derby of the season on Saturday.
A fierce work ethic, an astute tactical brain and the ability to forge superb team spirit all combined to make Italian Antonio Conte an acclaimed winner in his own country which is why Chelsea have chosen him to revive their fortunes in England.
Spurs beat Ajax 3-2 in the second leg of the semi-final on Wednesday and will face Liverpool on June 1 in Madrid.
It is a mark of how far Tottenham Hotspur have come that they start as favourites to win what could be a pivotal Champions League Group E fixture away to Bayer Leverkusen on Tuesday despite the absence of key defender Toby Alderweireld.
IMAGES from English Premier League matches played on Sunday
Solskjaer took full advantage of the chance that fell his way.
Tottenham Hotspur's Europa League hopes were crushed by mid-table Belgian side Gent, who booked their spot in the last 16 with a 2-2 draw at Wembley on Thursday as the hosts paid the penalty for Dele Alli's first-half red card.
Lucas Moura scored twice as Tottenham Hotspur romped to a 3-0 English Premier League win over Manchester United at Old Trafford on Monday as Jose Mourinho's team's defensive frailties were brutally exposed once again.
Tottenham Hotspur stormed back from 2-0 down to beat Burnley 4-2 in their FA Cup third-round replay on Wednesday despite resting their top striker in the once-fabled competition.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
Manchester City host Tottenham Hotspur on Saturday on the back of a record 15 successive English Premier League wins, and on the basis of their visitors' recent away form, a 16th victory appears to be the likely outcome.
Juergen Klopp's reign as Liverpool manager began with a few points made but only one gained from an exciting, end-to-end 0-0 draw against Tottenham Hotspur at White Hart Lane on Saturday.
Liverpool blew a chance take a vice-like grip on the title race and Chelsea suffered their worst league defeat in 23 years.
Here are five talking points from the weekend's Premier League action:
Manchester City's eight point advantage after 11 games is leading to talk of the Premier League title race being over in November, but as Manchester United manager Jose Mourinho noted - English football has a habit of throwing up surprises.
Five talking-points from the Premier League weekend after Manchester United extended their winning run against Tottenham Hotspur, Liverpool were made to work hard for their win at Brighton & Hove Albion and Arsenal losing at West Ham United.
News of all that's transpired on and off the football field
Images from the UEFA Champions League matches played on Wednesday night.
High drama ensued during the English Premier League matches on Wednesday as Spurs manager Jose Mourinho was booked while Brighton stunned Chelsea via Alireza Jahanbakhsh's superb equaliser to deny the Blues victory. Here is all the EPL action in IMAGES from Wednesday's matches.
Tottenham Hotspur climbed to third with a 3-1 win over Southampton while Chelsea hung on to fourth spot, above Arsenal on goal difference, despite a 2-1 defeat at Wolverhampton Wanderers.
'Without Harry Kane many people were talking about Sonny (Son Heung-min) but today it was Lucas Moura who scored three goals and you know if you don't respect all the players, you cannot only have 11 players'
Tottenham's task was made all the more difficult two minutes before the interval when forward Son Heung-min was sent off
After Sunday's 1-3 loss to Manchester City the calls for Jose Mourinho's ouster are only going to get louder.
Manchester City emerged from a trough of despair to beat Tottenham Hotspur 3-1 and move to within three points of the Premier League title at Wembley on Saturday.
Lionel Messi scored his maiden goal for Paris St Germain in Tuesday's 2-0 Champions League victory against Manchester City.