The Russian ended Djokovic's hopes of completing a sweep of all four Grand Slam titles in 2021 when he defeated the Serb in the US Open final in September to pick up his maiden major.
Here is a compilation of some of the best photos from 2021...
Rafael Nadal is generally a slow starter but should not have any problem getting past his first-round opponent, Germany's Yannick Hanfmann.
Defending champion Stefanos Tsitsipas came out on top from a thrilling quarter-final clash with Diego Schwartzman, prevailing 6-2, 6-7(3), 6-4 on Friday to set up a meeting with Alexander Zverev at the Monte Carlo Masters.
A round-up of all the tennis action from around the globe.
Daniil Medvedev was knocked out in the fourth round of Indian Wells by Bulgarian Grigor Dimitrov on Wednesday as the world number two's near-flawless start turned nightmarish in a 4-6, 6-4, 6-3 defeat.
Alcaraz outlasts Hurkacz, Ruud stunned at Canadian Open
'During the grass court season, I unfortunately experienced a setback with my knee, and have accepted that I must withdraw from the Tokyo Olympic Games.'
The Spaniard leads 23-15 on a head-to-head basis but the Swiss has won the last five encounters.
Muguruza seals semi-final berth, Pliskova beats Krejcikova at WTA Finals.
In his pre-tournament news conference in Toronto on Sunday, Nadal said a recurring foot issue he has been dealing with since 2005 returned at the French Open, where he fell to eventual champion Djokovic in the semi-finals.
Novak Djokovic enjoyed a stress-free return to US competition following a two year absence
Roberto Bautista Agut predicted a great future for Jannik Sinner after going down to the Italian teenager
Nadal has won the Australian and the French Open back-to-back and has the chance to become the first man to win all four majors in the same year
The 'Big Three' of men's tennis have found some "fresh energy" to thwart the charge of younger players on the tour, world number one Novak Djokovic said after setting up yet another title clash against his biggest rival against Rafael Nadal.
20-time Grand Slam champion Roger Federer returned from more than a year away for a last dance in tandem with great rival Rafael Nadal on a gripping and memorable finale by the Thames in front of a 17,500 sell-out crowd at London's O2 Arena on Friday.
A look at Roger Federer's worst five Grand Slam losses.
'My arm has been -- I have had an issue there for quite a while now. It has gotten bigger in the last couple of weeks, so I'm just trying to protect it.'
In the women's draw, Angelique Kerber was knocked out in a 6-3, 6-1 defeat to Czech Katerina Siniakova while Coco Gauf won her first ever match on clay.
Jabeur advances to first WTA 100 final in Madrid in style.
Images from Tuesday, Day 8 of the 2021 Wimbledon Championships, in London.
World number one Carlos Alcaraz retired injured against Holger Rune at the Paris Masters on Friday, sending his fellow 19-year-old through to the semi-finals, while Novak Djokovic and Felix Auger-Aliassime also sealed places in the last four.
IMAGES from matches on Day 4 of the US Open at Flushing Meadows in New York on Thursday.
Raducanu retires in Rome as back injury persists, Jabeur survives early scare
Alexander Zverev overcame late nerves to beat world number one Novak Djokovic on Saturday and set up a final showdown with Daniil Medvedev at the ATP Finals.
Three-times winner Serena Williams moved into the Toronto Open second round after beating Spain's Nuria Parrizas Diaz on Monday
Images from Day 1 of the 2023 Australian Open at Melbourne Park on Monday.
World number one Ash Barty delighted the Memorial Drive crowd by breezing through to the Adelaide International semi-finals with a comfortable 6-3, 6-4 victory over Sofia Kenin on Friday.
Claycourt master Rafael Nadal quickly adapted to his new surroundings at Roland Garros with a 6-2, 6-1, 6-3 demolition of German qualifier Yannick Hanfmann in the first round of the French Open on Monday.
World number three Roger Federer is playing his first tournament on clay for three years as he prepares for the French Open.
IMAGES from Day 9 of the French Open at Roland Garros in Paris on Monday.
'I am realistic, don't get me wrong, I know how difficult it is at this age right now to do another surgery and try it, but look, I want to be healthy and I'll go through the rehab process I think also with the goal while I am still active which I think is going to help me during this long period of time.'
A round-up of all tennis action on Saturday.
Images from Day 5 of the 2023 Wimbledon Championships on Friday.
Federer, Nadal and Djokovic had made it near impossible for their peers to live, and thrive, amongst them. But the coming generation, which hasn't been as scarred by defeat at the hands of the Big 3, may make tennis unpredictable again.
The unseeded Indo-Canadian pair defeated their fancied rivals 6-3, 3-6, 10-5 in a round of 16 tie of the ATP Masters 1000 event.
Raducanu stormed into the third round of the Cincinnati Open
Australian Nick Kyrgios produced another extraordinary performance to demolish compatriot Alex de Minaur 6-2, 6-3 at the Canadian Masters on Thursday, a day after stunning world number one Daniil Medvedev.
World number one Novak Djokovic produced a majestic display in a 7-5, 6-3 victory over American John Isner on Thursday to extend his winning streak in Asia.
Petra Martic kept her composure to advance to the Round of 16
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