Here's a look at Nadal's other early exits from the tournament:
Continuing their good run, Somdev Devvarman and Treat Conrad Huey moved to the semi-finals of the ATP Farmer's Classic with a comfortable straight sets win over Gilles Muller of Luxembourg and Briton Jamie Murray.
India's Somdev Devvarman and his Filipino doubles partnerTreat Conrad Huey shocked top seeded Brazilian pair of Marcelo Melo and Bruno Soares in straight sets to advance to the doubles quarter-finals of the ATP Farmer's Classic in Los Angeles, USA.
Andre Agassi has pulled out of this week's Legg Mason Tennis Classic in Washington to preserve energy for the U.S. Open.
The 35-year-old American beat Gilles Muller of Luxembourg in the final of the Los Angeles Open.
Petra Kvitova completed her preparations for an assault on a third Grand Slam title in triumphant style on Friday by downing fellow Czech Karolina Pliskova 7-6, 7-6 to win the Sydney International title.
Novak Djokovic will contest his 23rd consecutive grand slam quarter-final after easing past Luxembourg journeyman Gilles Muller 6-4, 7-5, 7-5 at the Australian Open on Monday.
Novak Djokovic has admitted that Andy Murray's attempt to surge to the top of the rankings has rejuvenated an otherwise mediocre season for the World No. 1.
Top seed Andy Murray slumped out of the ABN Amro World Tennis Tournament on Friday after being outplayed 6-4, 6-2 in the quarter-finals by Frenchman Gilles Simon.
Fourth seed Grigor Dimitrov survived a scare against Pierre-Hugues Herbert before holding his nerve to win 3-6, 6-2, 6-4 in the second round of the Monte Carlo Masters on Tuesday, while Dominic Thiem edged out Russian youngster Andrey Rublev.
Paire won his first ATP Tour title on the clay at Bastad in July and will go in search of his second against French Open champion Wawrinka, who served strongly in taking out Gilles Muller of Luxembourg.
Roger Federer began his pursuit for a sixth Swiss Indoors Basel title with an explosive 47-minute 6-2, 6-1 victory over Gilles Muller on Wednesday after Rafael Nadal reached the quarter-final with a 6-1, 6-1 win against Pierre-Hugues Herbert.
Sania Mirza and her Czech partner Barbora Strycova stormed into the quarter-finals of the BNP Paribas Open 2017 tennis tournament with a straight-set win over their opponents in the women's doubles at Indian Wells.
Defending champion Stanislas Wawrinka survived some anxious against Gilles Muller before proceeding into the men's singles semi-finals at the ATP Chennai Open tennis tournament.
Roger Federer and Rafael Nadal powered to third-round wins at the BNP Paribas Open at Indian Wells on Tuesday to set up a mouth-watering rematch of their recent Australian Open final.
Andy Murray and Rafael Nadal were winners but six seeds were beaten in a day of upsets in the second round at the Rogers Cup in Montreal on Thursday.
US tennis powerhouse Serena Williams dispatched France's Alize Cornet in two sets on Monday, ending a streak of weak family performances that saw older sister Venus eliminated from singles on Saturday and the pair knocked out in doubles on Sunday.
A gutsy Ramkumar Ramanathan buried a sluggish start to eke out an inspiring win over Alexander Kudryavtsev and enter the men's singles quarterfinals of the Chennai Open on Thursday. Wild-card Ramkumar worked his way to a 3-6, 6-4, 6-4 win over higher-ranked Russian, who had entered the event as a Lucky Loser. He next plays world no.45 Aljaz Bedene, who defeated Luca Vanni 5-7, 6-3, 6-4.
Marin Cilic, thrashed by Roger Federer in straight sets in Sunday's Wimbledon final, said he had been suffering from a blister in his foot during the showpiece clash.
Defending champion and top seed Stanislas Wawrinka scored a clinical 6-1, 6-4 win over Borna Coric of Croatia to progress to the men's singles quarter-finals at the ATP Chennai Open tennis tournament.
'Of course I feel that I can beat Rafa. He is looking good and injury free. But if I didn't think I could win I would not bother going out on the court'
PHOTOS from day seven of the Wimbledon championships at the All England Lawn Tennis in London on Wednesday
The 33-year-old left-hander from Luxembourg had lost all five of his previous tour finals but prevailed at the sixth attempt in the Australian Open warm-up event at the Olympic Tennis Centre.
India's Rohan Bopanna and his Romanian partner Florin Mergea entered the Sydney International final after a straight sets win over Thomaz Bellucci and Leonardo Mayer, on Friday.